A5101874787- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Musculoskeletal synovial abnormalities and treatments
- Gout, Hyperuricemia, Uric Acid
- Reproductive Biology and Fertility
- CNS Lymphoma Diagnosis and Treatment
- Sperm and Testicular Function
- Radiomics and Machine Learning in Medical Imaging
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- MRI in cancer diagnosis
- Congenital Heart Disease Studies
- Sports injuries and prevention
- Rheumatoid Arthritis Research and Therapies
- Cardiovascular Function and Risk Factors
- Immune Cell Function and Interaction
- Neurological Disease Mechanisms and Treatments
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Hepatocellular Carcinoma Treatment and Prognosis
- Healthcare and Venom Research
- Cardiac Fibrosis and Remodeling
- Force Microscopy Techniques and Applications
Nanjing Drum Tower Hospital
2018-2025
Yantai University
2023-2025
Shanghai Institute of Materia Medica
2023-2025
Chinese Academy of Sciences
2023-2025
Qingdao Agricultural University
2022-2024
Sun Yat-sen University
2015-2024
Sun Yat-sen University Cancer Center
2024
Capital Medical University
2017-2024
Beijing Shijitan Hospital
2022-2024
Minzu University of China
2024
Mechanical overload can be classified into pressure and volume overload, causing concentric eccentric cardiac hypertrophy, respectively. Here, we aimed to differentiate the load-mediated signaling pathways involved in versus hypertrophy. Pressure or was imposed on C57BL/6J mice by transverse aortic constriction (TAC) regurgitation (AR), After surgery (2 wk), left ventricular structure function were evaluated echocardiographic, hemodynamic, histological analyses. Signaling related fibrosis,...
Biliary atresia is a rare infant disease that predisposes patients to liver transplantation and death if not treated in time. However, early diagnosis challenging because the clinical manifestations laboratory tests of biliary overlap with other cholestatic diseases. Therefore, it very important develop simple, safe reliable method for atresia. Herein, novel NIR-II fluorescence probe, HZL2, high quantum yield, excellent biocompatibility, low cytotoxicity rapid excretion through gallbladder...
Accurate ultrasound (US) image segmentation is crucial for the screening and diagnosis of diseases. However, it faces two significant challenges: 1) pixel-level annotation a time-consuming laborious process; 2) presence shadow artifacts leads to missing anatomy ambiguous boundaries, which negatively impact reliable results. To address these challenges, we propose novel semi-supervised aware network with boundary refinement (SABR-Net). Specifically, add imitation regions original US, design...
Sperm motility is an important factor in the migration of sperm from uterus to oviduct. During preservation vitro, generates excessive ROS that damages its function. This study aims investigate whether addition pyrroloquinoline quinone (PQQ) diluted medium could improve chilled ram quality, and then elucidates mechanism. Ram semen was with Tris-citric acid-glucose (TCG) containing different doses PQQ (0 nM, 10 100 1000 10,000 nM), stored at 4 °C. patterns, plasma membrane integrity, acrosome...
Abstract Anticancer treatment is a worldwide challenge, and there are constant endeavors in this field to develop intelligent drug delivery systems improve the therapeutic effect. This paper presents novel ultrasound‐responsive microbubbles (UDMs), with chemotherapeutic‐encapsulated hydrogel shells gas cores. These developed using microfluidic electrospray treat pancreatic tumors. As composed of thermo‐sensitive poly(N‐isopropylacrylamide) (PNIPAM), they can contract under mild hyperthermia...
Sperm cryopreservation contributes to the extensive utilization of artificial insemination (AI) in daily livestock industry. However, due presence few sperm with good biological function post-thaw goat sperm, its use has been limited for AI purposes. Hence, improvement focus many research studies. This study aimed investigate effects proline supplementation freezing medium on sperm. The semen was cryopreserved different concentrations (0, 0.5, 1, 2 and 4 mM). motility patterns, membrane...
Metabolic dysfunction-associated steatotic liver disease (MASLD) (previously called nonalcoholic fatty disease, NAFLD) is associated with cardiometabolic risk factors and chronic kidney (CKD). However, evidence lacking regarding whether the severity of fibrosis affected by these diseases to what degree. We aimed determine correlation between vibration-controlled transient elastography-determined stiffness measurements (LSMs) controlled attenuation parameter (CAP) values in a sample US...
Abstract Gold nanoparticles (AuNPs) have emerged as promising tools in cancer theranostics, particularly applications involving photoacoustic imaging (PAI) and photothermal therapy (PTT). The optical thermal properties of AuNPs can be precisely tuned by adjusting their shape size, which, turn, influences performance within the first (NIR‐I) second near‐infrared (NIR‐II) bio‐windows. This study explores how variations morphology AuNPs, such nanorods nanodumbbells, affect longitudinal surface...
Primary breast diffuse large B‐cell lymphoma ( PB ‐ DLBCL ) is a rare subtype of with limited data on patterns failure. This multicenter study aimed to define the optimum treatment strategy and failure for patients. We retrospectively reviewed 108 patients from 21 Chinese medical centers. Only localized disease (involvement lymph nodes) were included. After median follow‐up 3.2 years, 32% developed progression or relapse. A continuous pattern relapse was observed, characterized by frequent...
Frozen-thawed boar sperm was not widely used in pig artificial insemination as the quality damaged by biochemical and physical modifications during cryopreservation process. The aim of this study to investigate whether reduction glucose level diluted medium could protect post-thaw or not. Boar with pre-treatment different doses (153, 122.4, 91.8, 61.2, 30.6, 0 mM) cooling motility patterns glycolysis were evaluated Meanwhile, quality, ATP level, mitochondrial function well apoptosis also...
Carboxylated ε-poly-l-lysine (CPLL), a novel cryoprotectant, can protect the sperm membranes by inhibiting ice crystal formation during cryopreservation process. The present study was conducted to investigate consequence of CPLL supplementation on post-thaw quality cryopreserved goat sperm. For this, different doses (0, 0.5%, 1%, 1.5%, and 2%; v/v) were added medium, motility, membrane acrosome integrity, mitochondrial potential (MMP), ATP level, ROS production, anti-oxidant defense system,...
Purpose: This study aimed to evaluate the multidrug resistance (MDR) reversal activity of quercetin (Que) in combination with hyperthermia (HT) human myelogenous leukemia cells K562/A.Methods: The cytotoxicity Que alone and effect HT doxorubicin (Dox) were determined using MTT assay K562 K562/A cells. was heated or without pretreatment, protein mRNA levels heat shock 70 (HSP70) P-glycoprotein (P-gp) by flow cytometry (FCM) RT-PCR, respectively. Intracellular accumulation Dox, cell cycle...
BACKGROUND:In this study, we investigated the potential neuroprotective effect of oleuropein (OLE) on apoptotic changes via modulating Akt/glycogen synthase kinase 3 beta (Akt/GSK-3b) signaling in a rat model cerebral ischemia/reperfusion injury (IRI). MATERIAL AND METHODS:Sprague-Dawley male rats (12 weeks, n=200) were randomly assigned to 5 groups: sham group, vehicle (IRI+ vehicle) OLE (IRI+OLE) OLE+LY294002 (IRI+OLE+LY294002) and LY294002(IRI+LY294002) group. The subjected (IRI) treated...
The rate of procedural success transfemoral transcatheter aortic valve replacement (TAVR) with self-expanding valves in patients pure native regurgitation (PNAR) is quite low. Which anatomy evaluated by computed tomography (CT) as well which kind associated higher remain unknown. aims this study were to evaluate the relationship between preprocedural CT indexes and compare rates 2 kinds different shaped frameworks.This was a retrospective comparative study. enrolled symptomatic severe PNAR,...
The gray-scale ultrasound (US) imaging method is usually used to assess synovitis in rheumatoid arthritis (RA) clinical practice. This four-grade scoring system depends highly on the sonographer's experience and has relatively lower validity compared with quantitative indexes. However, training of a qualified sonographer expensive time-consuming while few studies focused automatic RA grading methods. purpose this study propose an using deep convolutional neural networks (DCNN) assist...
We previously showed that Qiliqiangxin (QL) capsules could ameliorate cardiac hypertrophy and remodeling in a mouse model of pressure overload. Here, we compared the effects QL alone with those combined following 3 types antihypertensive drugs on dysfunction induced by overload for 4 weeks mice: an angiotensin II type 1 receptor (AT1-R) blocker (ARB), angiotensin-converting enzyme inhibitor (ACEI), β-adrenergic (β-AR) (BB). Adult male mice (C57B/L6) were subjected to either transverse aortic...
The combination of chemotherapy and L-asparaginase (L-ASP) treatment significantly increased survival rate in an adult patient with extranodal natural killer (NK)/T-cell lymphoma (NKTCL). However, hypersensitivity reactions L-ASP some patients limited its application. Polyethylene glycol-conjugated asparaginase (PEG-ASP) has a lower immunogenicity longer circulating half-life than unconjugated L-ASP, been reported to be effective well-tolerated children acute lymphoblastic leukemia....
The efficacy and safety of rituximab-based chemotherapy (R-chemo), the standard regimen for patients with diffuse large B-cell lymphoma (DLBCL), which is more common in Asia than Western countries, are well confirmed randomized controlled trials (RCTs). However, effectiveness R-chemo who largely excluded from RCTs have not been characterized. This real-world study investigated as first-line treatment Chinese DLBCL. Treatment-naive DLBCL were CD20 positive eligible to receive enrolled no...
Abstract Background Parents of children with autism spectrum disorder (ASD) are at a higher risk depression than parents typically developing and those other developmental disorders. Depression affects the well-being quality life ASD has serious consequences for long-term health outcomes ASD. Therefore, this study explored current status depressive symptoms in eastern China further analyzed multiple aspects predictors symptoms. Methods A multicenter cross-sectional survey was conducted among...