A5100354030- Virus-based gene therapy research
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Fungal Biology and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Reproductive Biology and Fertility
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gut microbiota and health
- HIV Research and Treatment
- Single-cell and spatial transcriptomics
- interferon and immune responses
- Microbial Natural Products and Biosynthesis
- Sperm and Testicular Function
- Plant Pathogens and Fungal Diseases
- Cervical Cancer and HPV Research
- Mycorrhizal Fungi and Plant Interactions
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
Harbin Medical University
2010-2025
Second Affiliated Hospital of Harbin Medical University
2010-2025
Guangzhou University of Chinese Medicine
2025
Binzhou Medical University
2025
Binzhou University
2025
China Medical University
2013-2024
First Hospital of China Medical University
2013-2024
Shandong Tumor Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Shandong University
2013-2024
Inflammation triggers secondary brain damage after stroke. The meninges and other CNS border compartments serve as invasion sites for leukocyte influx into the thus promoting tissue However, post-ischemic immune response of compared to parenchyma remains poorly characterized. Here, we deeply characterize tissue-resident leukocytes in discover that respond differently stroke depending on their site residence. We thereby a unique phenotype myeloid cells exclusive These stroke-associated...
Peripheral nerves contain axons and their enwrapping glia cells named Schwann (SCs) that are either myelinating (mySCs) or nonmyelinating (nmSCs). Our understanding of other in the peripheral nervous system (PNS) remains limited. Here, we provide an unbiased single cell transcriptomic characterization nondiseased rodent PNS. We identified independently confirmed markers previously underappreciated nmSCs nerve-associated fibroblasts. also found characterized two distinct populations...
Despite the high incidence of male infertility, only 30% infertile men receive a causative diagnosis. To explore regulatory mechanisms governing human germ cell function in normal and impaired spermatogenesis (crypto), we performed single-cell RNA sequencing (>30,000 cells). We find major alterations crypto spermatogonial compartment with increased numbers most undifferentiated spermatogonia (PIWIL4+). also observe transcriptional switch within driven by prolonged expression transcription...
In the past 37 years, human immunodeficiency virus/acquired syndrome (HIV/AIDS) has undergone various major transmission routes in China, with world most complex co-circulating HIV-1 subtypes, even prevalence is still low. response to first epidemic outbreak of HIV injecting drug users and second one by illegal commercial blood collection, China issued Anti-Drug Law launched Blood Donation Act nationwide nucleic acid testing, which avoided 98,232 211,200 estimated infections almost ended...
Safe and effective prophylactic therapies for radiation-induced dermatitis (RID) remain an unmet need.To determine if epigallocatechin-3-gallate (EGCG) solution reduces the incidence of RID in patients undergoing radiotherapy after breast cancer surgery.This phase 2 double-blind, placebo-controlled randomized clinical trial enrolled 180 with receiving postoperative at Shandong Cancer Hospital Institute Shandong, China, between November 2014 June 2019. Data analysis was performed from...
It has been reported that the PI3K/AKT signaling pathway plays a key role in pathogenesis of ischemic stroke. As result, development drugs targeting attracted increasing attention from researchers. This article reviews pathological mechanisms and advancements research related to pathways stroke, with focus on pathway. The findings include following: (1) complex stroke can be categorized into five major types: excitatory amino acid toxicity, Ca 2+ overload, inflammatory response, oxidative...
Cyclooxygenase-2 (COX-2) plays an important role in the carcinogenesis and progression of gastric cancer. It has been demonstrated that COX-2 overexpression depends on different cellular pathways, involving both transcriptional post-transcriptional regulation. MicroRNAs (miRNAs) are small, noncoding RNAs function as regulators. Here, we characterize miR-101 expression its regulation expression, which turn, will provide us with additional insights into potential therapeutic benefits exogenous...
The purpose of this study was to investigate the safety, tolerability and preliminary effectiveness topical epigallocatechin-3-gallate (EGCG) for radiation dermatitis in patients with breast cancer receiving adjuvant radiotherapy.Patients who received radiotherapy chest wall after mastectomy were enrolled. EGCG solution sprayed field from initiation Grade 1 until 2 weeks completion radiotherapy. concentration escalated 40 660 μmol l(-1) 7 levels 3-6 each level. toxicity graded using NCI...
Background The 2008 Wenchuan earthquake in China resulted great loss of life and property, previous studies have focused on psychopathological symptoms survivors after disasters. This study examined perceived family functioning its predictors disaster bereaved individuals eighteen months the earthquake. Methodology/Findings was a cross-sectional convenience sample 264 individuals. instruments used included Family APGAR Index, Adaptability Cohesion Evaluation Scale??, Emotional Social...
Abstract Exosomes have been suggested as promising targets for the diagnosis and treatment of neurological diseases, including schizophrenia (SCZ), but potential role exosome-derived metabolites in these diseases was rarely studied. Using ultra-performance liquid chromatography-tandem mass spectrometry, we performed first metabolomic study serum-derived exosomes from patients with SCZ. Our sample comprised 385 332 healthy controls recruited 3 clinical centers 4 independent cohorts. We...
The prophylactic vaccination of COVID-19 mRNA vaccines is the first large-scale application this kind in human world. Over 1.8 million doses vaccine had been administered US until December 2020, and around 0.2% submitted AE reports to Vaccine Adverse Event Reporting System (VAERS). This study aimed evaluate AEs following immunization (AEFIs) analyze potential associations based on information from VAERS database.We searched database recorded AEFIs after 2020. After data mapping, we...
Lipid metabolism plays an important role in the occurrence and development of cancer, particular, digestive system tumors such as colon cancer. Here, we investigated fatty acid-binding protein 5 (FABP5) colorectal cancer (CRC). We observed marked down-regulation FABP5 CRC. Data from functional assays revealed inhibitory effects on cell proliferation, colony formation, migration, invasion well tumor growth vivo. In terms mechanistic insights, interacted with acid synthase (FASN) activated...
Agricultural practices affect soil microbes which are critical to health and sustainable agriculture. To understand prokaryotic fungal assembly under agricultural practices, we use machine learning-based methods. We show that fertility source is the most pronounced factor for microbial especially fungi, its effect decreases with depths. Fertility also shapes co-occurrence patterns revealed by learning, leading fungi-dominated modules sensitive down 30 cm depth. Tillage affects microbiomes at...