A5083646645- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Neuroendocrine Tumor Research Advances
- Adenosine and Purinergic Signaling
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Pancreatic function and diabetes
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Inflammatory Bowel Disease
- Immune cells in cancer
- Peroxisome Proliferator-Activated Receptors
- Tissue Engineering and Regenerative Medicine
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Cancer Cells and Metastasis
- Congenital Diaphragmatic Hernia Studies
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Metastasis and carcinoma case studies
Jiangsu Province Hospital
2014-2025
Nanjing Medical University
2016-2025
Fudan University
2022
Heilongjiang University
2022
University of Electronic Science and Technology of China
2018
Nanjing Traditional Chinese Medicine Hospital
2017
Nanjing Drum Tower Hospital
2017
Abstract Background Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare. Hypoxia and lipid metabolism-related gene acetyl-CoA synthetase 2 (ACSS2) is involved in tumor progression, but its role pNENs not revealed. This study showed that hypoxia can upregulate ACSS2, which plays an important the occurrence development of through metabolism reprogramming. However, precise mechanisms ACSS2 remain unknown. Methods mRNA protein levels 3-hydroxy-3-methylglutaryl-CoA synthase1 (HMGCS1)...
To investigate the recent epidemiological trends of gastric neuroendocrine neoplasms (GNENs) and establish a new tool to estimate prognosis carcinoma (GNEC) tumor (GNET).Nomograms were established based on retrospective study patients diagnosed with GNENs from 1975 2016 in Surveillance, Epidemiology End Results database. External validation was performed among 246 Jiangsu province verify discrimination calibration nomograms.The age-adjusted incidence has increased 0.309 6.149 per 1,000,000...
Abstract Background N6-methyladenosine (m6A) modification is the most abundant reversible methylation in eukaryotes, and it reportedly closely associated with a variety of cancers progression, including colorectal cancer (CRC). This study showed that activated lipid metabolism glycolysis play vital roles occurrence development CRC. However, only few studies have reported biological mechanisms underlying this connection. Methods Protein mRNA levels FTO ALKBH5 were measured using western blot...
Lipid metabolism plays an important role in the occurrence and development of cancer, particular, digestive system tumors such as colon cancer. Here, we investigated fatty acid-binding protein 5 (FABP5) colorectal cancer (CRC). We observed marked down-regulation FABP5 CRC. Data from functional assays revealed inhibitory effects on cell proliferation, colony formation, migration, invasion well tumor growth vivo. In terms mechanistic insights, interacted with acid synthase (FASN) activated...
Abstract The role of PIWI-interacting RNAs (piRNA) in small extracellular vesicles (sEV) derived from pancreatic neuroendocrine neoplasms (PNEN) the tumor microenvironment (TME) remains unexplored. We used multiplex IHC to analyze expression CD68, CD276 (B7H3), and CD3 on PNEN. CD276+ tumor-associated macrophages (TAM) were more abundant tissues than nontumor negatively correlated with T-cell infiltration. Serum sEV piRNA sequencing was performed identify piRNAs enriched patients then...
Paclitaxel (Ptx), a type of microtubule depolymerization inhibitor, is one the main components in gastric cancer chemotherapy. Some studies have demonstrated that tetrandrine (Tet), bisbenzylisoquinoline alkaloid, has potential antitumor effects several cancers. Aside from direct anticancer effect, Tet proved to synergistically enhance effect Ptx cancer. However, application combinational strategy limited by poor solubility both drugs. Nanodrug delivery systems including polymeric...
Abstract N6‐methyladenosine modification, especially Wilms tumor 1‐associated protein (WTAP), is reportedly associated with a variety of cancers, including colorectal cancer (CRC). Angiogenesis also plays an important role in the occurrence and development CRC. However, only few studies have reported biological mechanisms underlying this connection. Therefore, tissue microarray public database were used to explore WTAP levels Then, was down‐regulated over‐expressed, respectively. CCK8, EdU,...
Pancreatic neuroendocrine neoplasms (pNENs) are among the most frequently occurring (NENs) and require targeted therapy. High levels of fatty acid binding protein 5 (FABP5) involved in tumor progression, but its role pNENs remains unclear. We investigated mRNA FABP5 pNEN tissues cell lines found them to be upregulated. evaluated changes proliferation using CCK-8, colony formation, 5-ethynyl-2'-deoxyuridine assays examined effects on migration invasion transwell assays. that knockdown...
The gut microbiota plays a significant role in the initiation and progression of tumors, but its rectal neuroendocrine tumors (rNETs) remains unclear. Fecal samples were collected from 19 healthy individuals 21 rNET patients,with cohort further divided into metastatic (rNETs-M) non-metastatic (rNETs-nM) groups. Using metagenomic high-throughput sequencing, we analyzed diversity, species composition, functional characteristics microbiota. We applied random forest model to identify potential...
N6-methyladenosine (m6A) is considered the most prevalent RNA epigenetic regulator in cancer. FTO, an m6A demethylase, has been implicated contributing to progression of various cancers by up-regulating expression multiple oncogenes. However, studies exploring its impact on lipid metabolism cancer, especially pNENs, remain scarce. In this study, we demonstrated that FTO was up-regulated pNENs and played a critical role tumor growth metabolism. Mechanistically, discovered over-expression...
Abstract Background It has been manifested in several studies that age-related metabolic reprogramming is associated with tumor progression, particular, colorectal cancer (CRC). Here we investigated the role of upregulated metabolites aged serum, including methylmalonic acid (MMA), phosphoenolpyruvate (PEP), and quinolinate (QA), CRC. Methods Functional assays CCK-8, EdU, colony formation transwell experiments were used to ascertain which metabolite elderly serum was related progression....
Abstract The process of post-transcriptional regulation has been recognized to be significantly impacted by the presence N 6-methyladenosine (m6A) modification. As an m6A demethylase, ALKBH5 shown contribute progression different cancers increasing expression several oncogenes. Hence, a better understanding key targets in cancer cells could potentially lead development new therapeutic targets. However, specific role pancreatic neuroendocrine neoplasms (pNENs) remains largely unknown. Here,...
// Jian’an Bai 1 , He Na 2 Xiumei Hua Yaling Wei Tian Ye Yiqiang Zhang 3 Guo Jian 4 Weiwen Zeng Lijun Yan Qiyun Tang Department of Gastroenterology, Sir Run Hospital Affiliated with Nanjing Medical University, Nanjing, China The First Radiology, Linyi People's Hospital, Dezhou, Orthopaedics, People’s Correspondence to: Tang, email: tqy831@163.com Keywords: NENs, epidemiology, LDL-C, PCSK9, miR-224 Received: February 29, 2016 Accepted: December 16,...
AIM:To investigate the role of serum-and-glucocorticoid-inducible-kinase-1 (SGK1) in colitis and its potential pathological mechanisms.METHODS: SGK1 expression mucosal biopsies from patients with active Crohn's disease (CD) normal controls was detected by immunohistochemistry.We established an acute model mice induced 2,4,6-trinitrobenzene sulfonicacid, demonstrated presence using activity index, histologic index hematoxylin eosin staining.The cellular events mechanisms were implemented...
Abstract Increasing evidence indicates that long non-coding RNA (lncRNA) is one of the most important regulators in pathogenesis neuroblastoma (NB). Here, we found FAM201A was low expressed NB and a variety gain loss function studies elucidated anti-tumor effects on regulation proliferation, migration invasion cells. Intriguingly, identified ability to encode tumor-suppressing protein, NBASP, which interacted with FABP5 negatively regulated its expression. In vivo assays also revealed NBASP...
Abstract Pancreatic neuroendocrine neoplasms (PanNENs) are a group of highly heterogeneous originating from the endocrine islet cells pancreas with characteristic differentiation, more than 60% which represent metastases when diagnosis, causing major tumor-related death. Metabolic alterations have been recognized as one hallmarks tumor metastasis, providing attractive therapeutic targets. However, little is known about molecular mechanism metabolic changes regulating PanNEN progression. In...
The study of multifunctional polymer micelles combined with chemotherapy due to reduced systemic toxicity and enhanced efficacy has attracted intensive attention. Herein, a core-cross-linked hybrid micelle system based on mPEG-b-PGu(BA-TPE) OCT-PEG-b-PGu(DA-TPE) pH- redox-triggered drug release aggregation-induced emission (AIE) active imaging been developed for targeting neuroendocrine neoplasms (NENs), especially carcinomas (NECs) poor prognosis. These showed excellent biocompatibility...
It has been shown that long noncoding RNA s (lnc s) are involved in the carcinogenesis of multiple cancers. However, roles lnc gastroenteropancreatic neuroendocrine neoplasms ( GEP ‐ NEN remain elusive. In present study, we found 885 was markedly decreased human gastric samples compared to adjacent normal tissues by transcriptome sequencing. Functionally, silencing or overexpression could not obviously affect cell proliferation apoptosis BON ‐1 LCC ‐18 cells but migration and invasion as...
Liver metastasis is one of the most important factors affecting prognosis patients with neuroendocrine neoplasms (NENs). Transhepatic artery embolization (TAE) main local treatment NENs liver (NENLM). This study aimed to elucidate differences between pancreatic and rectal NENLM a discrepancy in blood supply.A total 32 different primary sites received 102 TAE treatments at our hospital. Clinical features, such as age, sex, World Health Organization (WHO) tumour grade progression-free survival...