A5102912737- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Pancreatitis Pathology and Treatment
- Metabolomics and Mass Spectrometry Studies
- Metastasis and carcinoma case studies
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Peroxisome Proliferator-Activated Receptors
- Growth Hormone and Insulin-like Growth Factors
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- RNA Research and Splicing
- Childhood Cancer Survivors' Quality of Life
- Renal and related cancers
- Ginseng Biological Effects and Applications
Xuzhou Medical College
2008-2024
Second People’s Hospital of Huai’an
2008-2024
Recent studies have exhibited significant roles of lncRNAs in various tumors' development, including colon cancer. Our study focused on the biological lncRNA MALAT1 In our study, it was demonstrated that upregulated human cancer cell lines Lovo, HCT116, SW480, and HT29 cells compared to normal intestinal epithelial HIEC cells. Moreover, we observed miR‐129‐5p downregulated with a increase HMGB1 expression. Inhibition can inhibit proliferation SW480 HCT116 next, bioinformatics analysis used...
To investigate the recent epidemiological trends of gastric neuroendocrine neoplasms (GNENs) and establish a new tool to estimate prognosis carcinoma (GNEC) tumor (GNET).Nomograms were established based on retrospective study patients diagnosed with GNENs from 1975 2016 in Surveillance, Epidemiology End Results database. External validation was performed among 246 Jiangsu province verify discrimination calibration nomograms.The age-adjusted incidence has increased 0.309 6.149 per 1,000,000...
Objective This study aims to investigate the effect of red ginseng polysaccharide (RGP) on gastric cancer (GC) development and explore its mechanism.
Liver cancer is one of the most common malignant cancers worldwide. Systemic chemotherapy remains major treatment option, but with severe adverse effects. Combinations systemic targeted treatments may provide effective therapeutics. The objectives this study were to demonstrate if insulin-like growth factor-I receptor (IGF-IR) might serve as a functional target for liver and investigate chemo-sensitizing activity IGF-IR downregulation. knockdown was achieved by stable transfection cells...
MiR-301a is as an oncogene involved in the regulation of gastric cancer (GC) progression, but underlying mechanism unclear. This study was to explore lncRNA PCAT18/miR-301a/TP53INP1 axis regulating GC cell proliferation and metastasis. In present study, tissues lines were collected for detection PCAT18 expression. Herein, we found that significantly decreases human five lines. Overexpression inhibits viability, invasion migration cells tumour growth xenograft tumours. negatively regulates...
Our study mainly reports the specific mechanisms of microRNA (miR)-874-3p on drug resistance in gastric cancer (GC). Clinical specimen was collected. The upstream long non-coding RNA (lncRNA) and downstream gene miR-874-3p were predicted using bioinformatic analysis with results being ascertained dual-luciferase reporter assay. viability, apoptosis, migration invasion transfected GC cells or without cisplatin (DDP) treatment evaluated by Cell Counting Kit-8 (CCK-8), flow cytometric, Scratch,...
A specific liver disease during pregnancy is intrahepatic cholestasis of (ICP). The current clinical diagnosis mainly depends on the level serum total bile acid (TBA), which lacks sensitivity and specificity. Lactate dehydrogenase (LDHA) a new biomarker highly expressed in ICP patients, was screened by data-independent acquisition (DIA) proteomic technology our previous studies. There currently lack rapid, quantitative, sensitive detection method to measure LDHA levels serum. This study...
Objective To develop a safe and reliable method for the measurement of cholesterol net flux between macrophage cells human serum by high performance liquid chromatography,and to investigate relationship traditional risk factors atherosclerosis. Methods J774 (murine cell line) were plated in growth medium containing 5% individual before after incubation measured HPLC.Serum induced influx was calculated.Fasting blood samples 75 apparently healthy volunteers (38 males 37 females) from...
Objective To explore the animal model of acute lung injury induced by pancreatitis associated ascetic fluid in SD rats and its significance.Methods Rats were with hemorrhagic necrotic pancreatitis(AHNP)to create PAAF.The was established injection PAAF into their abdominal cavity.Respiratory frequency,Artery blood gas analysis,peripheral white cell count,serum amylase,and change structure pancreas lungs observed.Results After injection,the respiratory frequency peripheral count higher,and...