A5101477220- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Plant Disease Management Techniques
- Wnt/β-catenin signaling in development and cancer
- Phagocytosis and Immune Regulation
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Biomarkers in Disease Mechanisms
- Genomics and Phylogenetic Studies
- Photosynthetic Processes and Mechanisms
- 14-3-3 protein interactions
- Hops Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Antioxidant Activity and Oxidative Stress
- Chromatin Remodeling and Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Retinoids in leukemia and cellular processes
- Microbial Natural Products and Biosynthesis
- Plant Pathogens and Fungal Diseases
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
Henan Agricultural University
2017-2023
Nantong University
2022
Nanjing Medical University
2016-2022
Harbin University of Commerce
2022
Sichuan Agricultural University
2018-2021
Yangtze University
2020
Capital Medical University
2019
Beijing Tongren Hospital
2019
Ferroptosis plays a role in several diseases such as iron overload-induced liver diseases. Manipulation of ferroptosis has been explored potential therapeutic strategy to treat related Numerous antioxidants have identified control but the cell-autonomous mechanisms responsible for regulating remain elusive. In present study, we found that overload promoted hepatocytes by excessively inducing HO-1 expression, which contributed progression injury and fibrosis, accompanied upregulation FGF21...
BackgroundGlobal consumption of protein per capita is rising, while rates infertility are increasing. However, a clear relationship between intake and reproductive health has not been demonstrated. The activation the quiescent primordial follicles first step folliculogenesis, their must be tightly controlled to prevent premature exhaustion ovarian follicular reserve.MethodsThe follicle reserve wild-type or liver-specific ablation fibroblast growth factor 21 (FGF21) in mice, subjected limited...
// Jian’an Bai 1 , He Na 2 Xiumei Hua Yaling Wei Tian Ye Yiqiang Zhang 3 Guo Jian 4 Weiwen Zeng Lijun Yan Qiyun Tang Department of Gastroenterology, Sir Run Hospital Affiliated with Nanjing Medical University, Nanjing, China The First Radiology, Linyi People's Hospital, Dezhou, Orthopaedics, People’s Correspondence to: Tang, email: tqy831@163.com Keywords: NENs, epidemiology, LDL-C, PCSK9, miR-224 Received: February 29, 2016 Accepted: December 16,...
Both ovarian E2 and hepatic fibroblast growth factor 21 (FGF21) are critical for energy homeostasis white adipose tissue browning. Estrogen receptor α (ERα) is abundantly expressed in liver. However, whether FGF21 has a role E2-induced browning remains uncertain. In this study, we showed that Fgf21 expression secretion during estrus cycle changed with the tetradian oscillatory of circulation adult, female mice, their peak expressions secretions at proestrus. addition, exogenous robustly...
According to the World Health Organization, women's breast cancer is among most common cancers with 7.8 million diagnosed cases during 2016-2020 and encompasses 15 % of all female cancer-related mortalities. These mortality events from triple-negative are a significant health issue worldwide calling for continuous search bioactive compounds better treatments. Historically, plants important sources identifying such new chemicals Here we use high-throughput screening mass spectrometry analyses...
The pseudogene DUXAP10 is overexpressed in numerous types of human cancers. However, the diagnostic and prognostic value cancers has yet to be characterized. PubMed, EMBASE, Web Science, Cancer Genome Atlas (TCGA), Gene Expression Omnibus databases were comprehensively searched this study. A total 50 studies comprising 11,292 patients collected integrated analysis. was confirmed significantly various (p < .05). Summary receiver operating characteristic (SROC) curve analysis implemented,...
Background: Colorectal carcinoma (CRC) is one of the most prevalent malignancies globally. Ferroptosis, a novel type cell death, critical in development and treatment tumors. Objective: This study was designed to establish genetic signature for ferroptosis which has predictive effect on outcomes immunotherapeutic response CRC. Methods: Data CRC patients were retrieved from TCGA GEO databases. The genes associated with obtained GeneCards. identified by performing Cox regression analysis....
BACKGROUND Hepatocellular carcinoma (HCC) is not frequently diagnosed until the late stage due to its concealed symptoms. Therefore, identification of biomarkers that have effective diagnostic performance and act as potential key therapeutic targets for HCC becomes urgent. MATERIAL AND METHODS Comprehensive analysis accumulated data downloaded from Gene Expression Omnibus (GEO) Cancer Genome Atlas (TCGA) databases was used obtain more reliable explore related molecular mechanisms....
Adipose tissue inflammation plays an important role in the regulation of glucose and lipids metabolism. It is unknown whether Ursolic acid (UA) could regulate adipose inflammation, though it can many other tissues. In this study, 3T3-L1 adipocytes, DIO mice lean were treated with UA or vehicle. Gene expression inflammatory factors, chemokines immune markers adipocytes tissue, cytokines cell culture medium serum, regulatory pathways detected. Results showed that increased interleukins...
JinQi Jiangtang tablet (JQJTT) is a Chinese patent medicine that has been shown to be beneficial for patients with diabetes both preclinically and clinically; however, the molecular mechanism underlying effects of JQJTT remains unclear. In this study, surface plasmon resonance fishing was employed identify constituent molecules can specifically bind fibroblast growth factor receptor 1 (FGFR1), leading retrieval palmatine (PAL), key active ingredient JQJTT. vivo in vitro experiments...
Global per capita consumption of protein is rising, while infertility becoming prevailing. Here we found that mouse primordial follicle activation, the first step folliculogenesis, was reduced by restricted intake and accelerated excessive intake, in an ovarian mTORC1 signaling-dependent manner. Furthermore, or resulted augmentation decline oocyte number fertility at older age, respectively. Liver-specific ablation fibroblast growth factor 21 (FGF21), which a reduction 87% circulating FGF21,...