A5032457463- Animal Nutrition and Physiology
- Gut microbiota and health
- Animal Behavior and Welfare Studies
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Polysaccharides and Plant Cell Walls
- Luminescence and Fluorescent Materials
- Agriculture Sustainability and Environmental Impact
- Infant Nutrition and Health
- Molecular Sensors and Ion Detection
- Peroxisome Proliferator-Activated Receptors
- Drug Transport and Resistance Mechanisms
- Fibroblast Growth Factor Research
- Meat and Animal Product Quality
- Reproductive Physiology in Livestock
- Selenium in Biological Systems
- Reproductive Biology and Fertility
- Fungal Biology and Applications
- Autophagy in Disease and Therapy
- Dietary Effects on Health
- Reproductive System and Pregnancy
- Rabbits: Nutrition, Reproduction, Health
- Folate and B Vitamins Research
Sichuan Agricultural University
2016-2025
Ministry of Agriculture and Rural Affairs
2019-2025
Central South University
2019-2025
Hubei University
2025
Chinese Academy of Sciences
2006-2025
Shenyang Institute of Automation
2025
Ministry of Education of the People's Republic of China
2017-2024
Shenzhen Center for Disease Control and Prevention
2024
First Affiliated Hospital of Soochow University
2021-2024
Soochow University
2021-2024
Ferroptosis plays a role in several diseases such as iron overload-induced liver diseases. Manipulation of ferroptosis has been explored potential therapeutic strategy to treat related Numerous antioxidants have identified control but the cell-autonomous mechanisms responsible for regulating remain elusive. In present study, we found that overload promoted hepatocytes by excessively inducing HO-1 expression, which contributed progression injury and fibrosis, accompanied upregulation FGF21...
Abstract Co‐fermentation of lignocellulose‐based carbohydrates is a potential solution to improve the economics microbial lipid production. In present paper, experiments were performed optimize media composition for production by oleaginous yeast Lipomyces starkeyi AS 2.1560 through co‐fermentation glucose and xylose (2 : 1 wt/wt). Statistical screening nine variables was Plackett–Burman design. Three factors, namely mixed sugar, extract FeSO 4 , found as significant components influencing...
Free‐fatty acids (FFAs) are well‐characterized factor for causing production of inflammatory factors and insulin resistance in adipocytes. Using cultured adipocytes, we demonstrate that FFAs can activate endoplasmic reticulum (ER) stress pathway by examination ER sensor activation marker gene expression. Chemical chaperone tauroursodeoxycholic acid (TUDCA) reduce FFA‐induced adipocyte inflammation improve signaling whereas overexpression spliced X‐box protein 1 (XBP‐1s) only attenuates...
Background Obesity-related adipose inflammation has been thought to be a causal factor for the development of insulin resistance and type 2 diabetes. Infiltrated macrophages in tissue obese animals humans are an important source inflammatory cytokines. Clodronate liposomes can ablate by inducing apoptosis. In this study, we aim determine whether peritoneal injection clodronate any beneficial effect on systemic glucose homeostasis/insulin sensitivity macrophage content visceral will reduced...
Based on previous studies about microflora regulation and immunity enhancement activities of polysaccharides from Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen (CPP), there is little study intestinal mucosal immunity, which a possible medium for contacting immunity. In the present study, BALB/c mice were divided into five groups (eight in each group), including normal group (Con), model control (Model), that administered CPP (50, 100, 200 mg/kg/d) orally day seven days after...
Weanling pigs, with immature immune system and physiological function, usually experience post-weaning diarrhea. This study determined the effects of dietary Clostridium butyricum supplementation on growth performance, diarrhea, immunity weaned pigs challenged lipopolysaccharide (LPS).In Experiment (Exp.) 1, 144 piglets were at 21 d randomly assigned to six groups, replicates per group four replicate, receiving a control diet (CON) or supplemented antibiotics (AB) C. (CB) (0.1%, 0.2%, 0.4%,...
Brain and muscle arnt-like protein 1 (Bmal1) is a crucial transcription factor, regulating circadian rhythm involved in multiple heart diseases. However, it unknown whether Bmal1 promotes diabetic cardiomyopathy (DCM) pathogenesis. The objective of this investigation was to ascertain the vital role progression DCM. Mice with T2D H9c2 cardiomyoblasts exposed high glucose palmitic acid (HGHP) were used. Cardiomyocyte-specific knockout mouse (CKB) also generated, cardiac overexpressed type 2...
ABSTRACT 1,8-Dihydroxynaphthalene (1,8-DHN) is a fungal polyketide that contributes to virulence when polymerized 1,8-DHN melanin in the cell walls of Wangiella dermatitidis , an agent phaeohyphomycosis humans. To begin genetic analysis initial synthetic steps leading biosynthesis, 772-bp PCR product was amplified from genomic DNA using primers based on conserved regions synthases (Pks) known produce first cyclized 1,8-DHN-melanin pathway intermediate, 1,3,6,8-tetrahydroxynaphthalene. The...
Insulin resistance results in dysregulated hepatic gluconeogenesis that contributes to obesity-related hyperglycemia and progression of type 2 diabetes mellitus (T2DM). Recent studies show MAPK phosphatase-3 (MKP-3) promotes gluconeogenic gene transcription hepatoma cells, but little is known about the physiological role MKP-3 vivo. Here, we have shown expression markedly increased liver diet-induced obese mice. Consistent with this, adenovirus-mediated overexpression lean mice promoted...
To study the effects of maternal dietary fiber composition during gestation on offspring antioxidant capacity, inflammation, and gut microbiota composition, we randomly assigned 64 gilts to four treatments administered diets with an insoluble/soluble ratio 3.89 (R1), 5.59 (R2), 9.12 (R3), 12.81 (R4). Sow samples (blood feces at 110) neonatal (blood, liver, colonic contents) were collected. The results showed that sows piglets in R1 R2 had higher enzyme activity lower pro-inflammatory factor...
Capsaicin, which is the pungent ingredient of red hot chili peppers, has been reported to possess anticancer activity, including that against hepatocellular carcinoma. However, precise molecular mechanisms by capsaicin exerts its effects remain poorly understood. Herein, we have tested involvement autophagy in mechanism action human HepG2 cancer cells were treated with different doses (50, 100 and 200μmol/L) for 6, 12, 24 h. Flow cytometry Caspase-3 activity assay performed determine cell...
This study aimed to investigate the effects of dietary live yeast (LY) supplementation on growth, intestinal permeability and immunological parameters piglets challenged with enterotoxigenic Escherichia coli K88 (ETEC). Piglets weaned at 21 d were allocated into three treatments six pens per pen, receiving control diet (CON), diets supplemented antibiotics plus zinc oxide (ANT-ZnO) LY (Saccharomyces cerevisiae strain CNCM I-4407), respectively, for a period 2 weeks. On day 8, thirty-six...
We investigated the effects of dietary supplementation with Bacillus subtilis PB6 (B. PB6) during late gestation and lactation on sow reproductive performance, antioxidant indices, gut microbiota. A total 32 healthy Landrace × Yorkshire sows d 90 were randomly assigned to 2 groups, 16 replicates per group, receiving basal diet (CON) or + 0.2% B. PB6, containing 4.0 108 CFU/kg feed (BS). The litter sizes (total born) numbers piglets born alive larger in BS group (P < 0.01), whereas weights...