A5053836457- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Free Radicals and Antioxidants
- Antioxidant Activity and Oxidative Stress
- Redox biology and oxidative stress
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Muscle Physiology and Disorders
- Cancer Immunotherapy and Biomarkers
- Birth, Development, and Health
- Ferroptosis and cancer prognosis
- Glutathione Transferases and Polymorphisms
- Cancer-related molecular mechanisms research
- Chromium effects and bioremediation
- Coenzyme Q10 studies and effects
- Exercise and Physiological Responses
- Hedgehog Signaling Pathway Studies
- Tryptophan and brain disorders
- earthquake and tectonic studies
- Nitric Oxide and Endothelin Effects
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Disorders and Treatments
- MicroRNA in disease regulation
Shaanxi University of Technology
2024-2025
Qingdao Mental Health Center
2022-2025
Purdue University West Lafayette
2024-2025
Gansu Agricultural University
2025
University of Hong Kong
2023-2024
First Affiliated Hospital of Zhengzhou University
2024
Lanzhou University
2020-2023
Lanzhou University Second Hospital
2021-2023
Institute of Geology, China Earthquake Administration
2017-2022
China Earthquake Administration
2017-2022
Summary Oxidative stress is reputed to be a significant contributor the aging process and key factor affecting species longevity. The tremendous natural variation in maximum lifespan may due interspecific differences reactive oxygen generation, antioxidant defenses and/or levels of accrued oxidative damage cellular macromolecules (such as DNA, lipids proteins). present study tests if exceptional longevity longest living (> 28.3 years) rodent known, naked mole‐rat (NMR, Heterocephalus...
Glutathione peroxidase 4 (Gpx4) is uniquely involved in the detoxification of oxidative damage to membrane lipids. Our previous studies showed that Gpx4 essential for mouse survival and deficiency makes cells vulnerable injury. In present study, we generated two lines transgenic mice overexpressing (Tg(GPX4) mice) using a genomic clone containing human GPX4 gene. Both Tg-(GPX4) mice, Tg5 Tg6, had elevated levels (mRNA protein) all tissues investigated, overexpression did not cause...
How higher organisms respond to elevated oxidative stress in vivo is poorly understood. Therefore, we measured parameters and gene expression alterations (Affymetrix arrays) the liver caused by reactive oxygen species induced diquat or genetic ablation of major antioxidant enzymes CuZn-superoxide dismutase ( Sod1) glutathione peroxidase-1 Gpx1). Diquat (50 mg/kg) treatment resulted a significant increase damage within 3–6 h wild-type mice without any lethality. In contrast, Sod1 −/− Gpx1...
Genetic manipulations of Mn superoxide dismutase (MnSOD), SOD2 expression have demonstrated that altering the level MnSOD activity is critical for cellular function and life span in invertebrates. In mammals, Sod2 homozygous knockout mice die shortly after birth, alterations levels are correlated with changes oxidative damage generation mitochondrial reactive oxygen species. this study, we directly tested effects overexpressing young (4–6 months) old (26–28 on function, or stress, span,...
To test the impact of increased mitochondrial oxidative stress as a mechanism underlying aging and age-related pathologies, we generated mice with combined deficiency in two mitochondrial-localized antioxidant enzymes, Mn superoxide dismutase (MnSOD) glutathione peroxidase-1 (Gpx-1). We compared life span, pathology, damage Gpx1−/−, Sod2+/−Gpx1+/−, Sod2+/−Gpx1−/−, wild-type control mice. Oxidative was elevated Sod2+/−Gpx1−/− mice, shown by DNA oxidation liver skeletal muscle protein brain....
Glutathione peroxidase 4 (Gpx4) is an antioxidant defense enzyme that plays important role in detoxification of oxidative damage to membrane lipids. Because stress proposed play a causal aging, we compared the life spans Gpx4 heterozygous knockout mice (Gpx4+/− mice) and wild-type (WT mice). To our surprise, median span Gpx4+/− (1029 days) was significantly longer than WT (963 even though expression reduced approximately 50% all tissues mice. Pathological analysis revealed showed delayed...
Summary H 2 O is a major reactive oxygen species produced by mitochondria that implicated to be important in aging and pathogenesis of diseases such as diabetes; however, the cellular physiological roles mitochondrial remain poorly understood. Peroxiredoxin 3 (Prdx3/Prx3) thioredoxin peroxidase localized mitochondria. To understand age‐associated diseases, we generated transgenic mice overexpressing Prdx3 (Tg(PRDX3) mice). Tg(PRDX3) overexpress broad range tissues, overexpression occurs...
Abstract: Cardiac arrhythmias during ischemia/reperfusion are believed to be related free radicals generated in the heart especially period of reperfusion. Since melatonin functions as a radical scavenger and antioxidant, ability this molecule influence cardiac was investigated. The pineal secretory product, melatonin, reduced incidence severity induced by due ligation anterior descending coronary artery isolated rat heart. Melatonin either infused both ischemia reperfusion periods or only...
The free radical theory of aging proposes that the accumulation oxidative damage is a key component process. discovery F2-isoprostanes (F2-isoPs) and their establishment as sensitive accurate biomarker lipid peroxidation represents major advance for measuring stress status an organism. We have shown plasma total (free plus esterified) F2-isoPs increase with age (185% 66%, respectively), these increases are reduced by life-extending caloric restriction (50% 23%, respectively). In addition, we...
There is a high burden of both diabetes (DM) and tuberculosis (TB) in China, as DM increases the risk TB adversely affects treatment outcomes, there need for bidirectional screening two diseases. How this best performed not well determined. In pilot project we aimed to assess feasibility results patients within routine healthcare setting five clinics.Agreement on how screen, monitor record was reached May 2011 at national stakeholders meeting, training carried out staff clinics July 2011....
Abstract Age‐related loss of muscle mass and function, sarcopenia, has a major impact on the quality life in elderly. Among proposed causes sarcopenia are mitochondrial dysfunction accumulated oxidative damage during aging. Dietary restriction (DR), robust dietary intervention that extends lifespan modulates age‐related pathology variety species, been shown to protect from rodents. Although mechanism(s) by which DR aging still not defined, one potential mechanism is through modulation stress...