A5071854848- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Dietary Effects on Health
- Epigenetics and DNA Methylation
- Retinal Development and Disorders
- Circadian rhythm and melatonin
- Retinal Diseases and Treatments
- Regulation of Appetite and Obesity
- Growth Hormone and Insulin-like Growth Factors
- Birth, Development, and Health
- Stress Responses and Cortisol
- Sirtuins and Resveratrol in Medicine
- Muscle Physiology and Disorders
- Gut microbiota and health
- Genetics and Neurodevelopmental Disorders
- Identity, Memory, and Therapy
- Retinal Imaging and Analysis
- MicroRNA in disease regulation
- Glaucoma and retinal disorders
- Mitochondrial Function and Pathology
- Genetic Syndromes and Imprinting
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
National Institutes of Health
2014-2024
National Institute on Aging
2015-2024
Institute on Aging
2006-2023
Government of the United States of America
2022
National Cancer Institute
2020
E.ON (Germany)
2006-2013
Johns Hopkins Bayview Medical Center
2009
Johns Hopkins University
2009
University of Arizona
2008
Gynecologic Oncology Associates
2004-2007
Abstract Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact nonhuman primates has been controversial. In late 1980s two parallel studies were initiated to determine effect CR rhesus monkeys. The University Wisconsin study reported a significant positive on survival, National Institute Aging detected no survival effect. Here we present direct comparison longitudinal data from both including bodyweight,...
The most robust intervention for slowing aging and maintaining health function in animals is dietary caloric restriction (CR) ([1][1]). Although studies of this phenomenon have been conducted rodents lower animals, data accumulating from rhesus monkeys suggest that CR may also be
We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in primate model Parkinson's disease. Adult male rhesus monkeys were maintained for 6 months on reduced-calorie [30% caloric restriction (CR)] or an ad libitum control after which they subjected to treatment with neurotoxin produce hemiparkinson condition. After treatment, CR exhibited significantly higher levels locomotor activity compared as well dopamine (DA) DA metabolites striatal...
Progress in gerontological research has been promoted through the use of numerous animal models, which have helped identify possible mechanisms aging and age-related chronic diseases evaluate interventions with potential relevance to human disease. Further development nonhuman primate particularly rhesus monkeys, could accelerate this progress, because their closer genetic relationship humans produces a highly similar phenotype. Because relatively long lives primates increase administrative...
Aging | doi:10.18632/aging.100603. Nicole Noren Hooten, Megan Fitzpatrick, William H. Wood, Supriyo De, Ngozi Ejiogu, Yongqing Zhang, Julie A. Mattison, Kevin G. Becker, Alan B. Zonderman, Michele K. Evans
Abstract Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation pan-tissue epigenetic clocks. Here, we demonstrate development universal pan-mammalian clocks, 11,754 arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate age with high accuracy ( r > 0.96). Age deviations correlate human mortality risk, mouse somatotropic...
Lipid overload-induced heart dysfunction is characterized by cardiomyocyte death, myocardial remodeling, and compromised contractility, but the impact of excessive lipid supply on cardiac function remains poorly understood.To investigate regulation mitochondrial fission protein Drp1 (dynamin-related 1) in death dysfunction.Mice fed a high-fat diet (HFD) developed signs obesity type II diabetes mellitus, including hyperlipidemia, hyperglycemia, hyperinsulinemia, hypertension. HFD for 18 weeks...
Using DNA methylation profiles (
Caloric restriction (CR) has long been known to increase median and maximal lifespans decreases mortality morbidity in short-lived animal models, likely by altering fundamental biological processes that regulate aging longevity. In rodents, CR was reported delay the of immune system (immune senescence), which is believed be largely responsible for a dramatic age-related susceptibility infectious diseases. However, it unclear whether can exert similar effects long-lived organisms. Previous...
Recent studies from our laboratories and others suggest that calorie restriction (CR) may benefit Alzheimer's disease (AD) by preventing amyloid-beta (Abeta) neuropathology in the mouse models of AD. Moreover, we found promotion NAD+-dependent SIRT1 mediated deacetylase activity, a key regulator CR extension life span, be mechanism which influences AD-type neuropathology. In this study continued to explore role brain amyloidosis Squirrel monkeys (Saimiri sciureus). Monkeys were maintained on...
The increase of insulin resistance in “healthy” aging can be explained by a gut microbiota–monocyte–B1a B cell axis.
Metabolic diseases are characterized by the failure of regulatory genes or proteins to effectively orchestrate specific pathways involved in control many biological processes. In addition classical regulators, recent discoveries have shown remarkable role small noncoding RNAs (microRNAs [miRNAs]) posttranscriptional regulation gene expression. this regard, we recently demonstrated that miR-33a and miR33b, intronic miRNAs located within sterol element-binding protein (SREBP) genes, regulate...
Calorie restriction (CR) has been known for more than 70 years to extend life span and delay disease in rodent models. Metformin administration models shown cancer incidence progression, reduce cardiovascular span. To directly test the potential of metformin supplementation (300 mg/kg/day) as a CR mimetic, life-span studies were performed Fischer-344 rats compared with ad libitum feeding (30%). The group had significantly reduced food intake body weight throughout study. Body was control...
hsa-miR-33a and hsa-miR-33b, intronic microRNAs (miRNAs) located within the sterol regulatory element-binding protein 2 1 genes (Srebp-2 -1), respectively, have recently been shown to regulate lipid homeostasis in concert with their host genes. Although functional role of miR-33a -b has highly investigated, passenger strands, miR-33a* -b*, remains unclear. Here, we demonstrate that -b* accumulate steady-state levels human, mouse, nonhuman primate tissues share a similar metabolism target...