Andrew N. Hogan
A5002471153- Epigenetics and DNA Methylation
- Human-Animal Interaction Studies
- Genetic and phenotypic traits in livestock
- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Gut microbiota and health
- Genetics and Neurodevelopmental Disorders
- Wildlife Ecology and Conservation
- Identity, Memory, and Therapy
- Lysosomal Storage Disorders Research
- Genomics and Phylogenetic Studies
- Williams Syndrome Research
- Cancer-related gene regulation
- Birth, Development, and Health
- Cellular transport and secretion
- Forensic Anthropology and Bioarchaeology Studies
- RNA modifications and cancer
- Congenital heart defects research
- Carbohydrate Chemistry and Synthesis
National Human Genome Research Institute
2017-2024
National Institutes of Health
2017-2023
Cancer Genetics (United States)
2017-2023
Abstract Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and breed-associated behaviors resulting from human selective pressures. To identify the genetic underpinnings such traits, we analyze 722 canine whole genome sequences (WGS), documenting over 91 million single nucleotide small indels, creating a large catalog genomic variation for companion animal species. We undertake both sweep analyses wide association studies (GWAS) inclusive 144 modern...
Abstract Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation pan-tissue epigenetic clocks. Here, we demonstrate development universal pan-mammalian clocks, 11,754 arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate age with high accuracy ( r > 0.96). Age deviations correlate human mortality risk, mouse somatotropic...
We hypothesize that selection during dog domestication targeted CNVs associated with hypersociability.
Using DNA methylation profiles (
ABSTRACT Aging is often perceived as a degenerative process resulting from random accrual of cellular damage over time. Despite this, age can be accurately estimated by epigenetic clocks based on DNA methylation profiles almost any tissue the body. Since such pan-tissue have been successfully developed for several different species, we hypothesized that one build pan-mammalian measure in all mammalian species. To address generated data using 11,754 arrays, each profiling up to 36 thousand...
Significance Epigenetic estimators of age (known as clocks) allow one to identify interventions that slow or reverse aging. Previous epigenetic clocks only applied species at a time. Here, we describe apply both dogs and humans. These clocks, which measure methylation levels in highly conserved stretches the DNA, promise increase likelihood will have same effect other.
Domestic dogs (Canis lupus familiaris) are the most variable-sized mammalian species on Earth, displaying a 40-fold size difference between breeds.1Wayne R.K. Ostrander E.A. Origin, genetic diversity, and genome structure of domestic dog.BioEssays. 1999; 21: 247-257Google Scholar Although variable found in archeological record,2Bergström A. Frantz L. Schmidt R. Ersmark E. Lebrasseur O. Girdland-Flink Lin A.T. Storå J. Sjögren K.-G. Anthony D. et al.Origins legacy prehistoric dogs.Science....
Abstract Through thousands of years breeding and strong human selection, the dog ( Canis lupus familiaris ) exists today within hundreds closed populations throughout world, each with defined phenotypes. A singular geographic region broad diversity in breeds presents an interesting opportunity to observe potential mechanisms breed formation. Italy claims 14 internationally recognized breeds, numerous additional local varieties. To determine relationship among Italian populations, we...
Abstract Maximum lifespan of a species is the oldest that individuals can survive, reflecting genetic limit longevity in an ideal environment. Here we report methylation-based models accurately predict maximum (r=0.89), gestational time (r=0.96), and age at sexual maturity (r=0.87), using cytosine methylation patterns collected from over 12,000 samples derived 192 mammalian species. Our epigenetic predictor corroborated extended growth hormone receptor knockout mice rapamycin treated mice....
Summary Epigenetics has hitherto been studied and understood largely at the level of individual organisms. Here, we report a multi-faceted investigation DNA methylation across 11,117 samples from 176 different species. We performed an unbiased clustering cytosines into 55 modules identified 31 related to primary traits including age, species lifespan, sex, adult weight, tissue type phylogenetic order. Analysis correlation between allowed us construct phyloepigenetic trees for tissues that...
Glucocerebrosidase (GCase) is implicated in both a rare, monogenic disorder (Gaucher disease, GD) and common, multifactorial condition (Parkinson’s PD); hence, it an urgent therapeutic target. To identify correctors of severe protein misfolding trafficking obstruction manifested by the pathogenic L444P-variant GCase, we developed suite quantitative, high-throughput, cell-based assays. First, labeled GCase with small proluminescent HiBiT peptide reporter tag, enabling quantitation...
ABSTRACT DNA methylation profiles have been used to develop biomarkers of aging known as epigenetic clocks, which predict chronological age with remarkable accuracy and show promise for inferring health status an indicator biological age. Epigenetic clocks were first built monitor human but the principles underpinning them appear be evolutionarily conserved, they now successfully developed over 120 mammalian species. Here we describe reliable highly accurate shown apply 51 domestic dog...
SUMMARY Mammals progress through similar physiological stages during life, from early development to puberty, aging, and death. Yet, the extent which this conserved physiology reflects molecular events is unclear. Here, we map common epigenetic changes experienced by mammalian genomes as they age, focusing on evolutionary comparisons of humans dogs, an emerging model aging. Using targeted sequencing, characterize methylomes 104 Labrador retrievers spanning a 16 year age range, achieving...
Most modern dog breeds were developed within the last two hundred years, following strong and recent human selection based predominantly on aesthetics, with few constructed solely to maximize their work potential. In many cases, these working represent remnants of now lost populations. The Patagonian sheepdog (PGOD), a rare herding breed, is remarkable example such population. Maintained as an isolated population for over 130 PGOD offers unique opportunity understand genetic relationship...