A5013677686- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Breastfeeding Practices and Influences
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Genetics and Neurodevelopmental Disorders
- Infant Nutrition and Health
- Maternal and fetal healthcare
- Genetics, Aging, and Longevity in Model Organisms
- RNA modifications and cancer
- Obesity, Physical Activity, Diet
- Neonatal Respiratory Health Research
- Diet, Metabolism, and Disease
- Child Nutrition and Feeding Issues
- Prenatal Screening and Diagnostics
- Bariatric Surgery and Outcomes
- Fetal and Pediatric Neurological Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Marine animal studies overview
- Demographic Trends and Gender Preferences
Tufts University
2020-2025
Tufts Medical Center
2020-2025
University Medical Center
2020
MetroHealth Medical Center
2013-2018
MetroHealth
2013-2018
Case Western Reserve University
2013-2018
Oregon Health & Science University
2012
Obese women, on average, give birth to babies with high fat mass. Placental lipid metabolism alters fetal delivery, potentially moderating neonatal adiposity, yet how it is affected by maternal obesity poorly understood. We hypothesized that fatty acid (FA) accumulation (esterification) higher and FA β-oxidation (FAO) lower in placentas from obese, compared lean women. assessed acylcarnitine profiles (lipid oxidation intermediates) mother–baby–placenta triads, addition content, messenger RNA...
Background: The placentas of obese women accumulate lipids that may alter fetal lipid exposure. long-chain omega-3 fatty acids (n–3 FAs) docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) FA metabolism in hepatocytes, although their effect on the placenta is poorly understood. Objective: We aimed to investigate whether n–3 supplementation during pregnancy affects overweight at term. Design: A secondary analysis a double-blind randomized controlled trial was conducted healthy pregnant who...
The sensitivity of the placenta to maternal insulin remains controversial. Early pregnancy may be a time increased placental because receptors are abundant on syncytiotrophoblast in first trimester but far fewer at term.Maternal secretory response early, not late, is positively associated with growth.This secondary analysis cohort women (n = 40) recruited before pregnancy.An iv glucose tolerance test was administered and early (12-14 weeks) late (34-36 pregnancy. Placental volume throughout...
Food and nutrition-related factors have the potential to impact development of autism spectrum disorder (ASD) quality life for people with ASD, but gaps in evidence exist. On November 10, 2022, Tufts University's Friedman School Nutrition Science Policy Innovation Institute hosted a one-day meeting explore regarding relationships food nutrition ASD. This report summarizes presentations deliberations from meeting. Topics addressed included prenatal child dietary intake, microbiome, obesity,...
Abstract Objectives Maternal obesity increases a child’s risk of neurodevelopmental impairment. However, little is known about the impact maternal on fetal brain development. Methods We prospectively recruited 20 healthy pregnant women across range pre-pregnancy or first-trimester body mass index (BMI) and performed magnetic resonance imaging (MRI) their singleton fetuses. examined correlations between early pregnancy BMI regional volume living fetuses using volumetric MRI analysis. Results...
Nutrition during pregnancy significantly impacts maternal and birth outcomes. A key factor contributing to the rise in adverse outcomes is poor nutrition. Produce prescription programs have potential address pregnancy-related such as hypertensive disorders gestational diabetes, but scientific evidence limited. To conduct qualitative interviews gain an in-depth understanding of how, why, what context should produce prescriptions be implemented best meet needs pregnant women a clinical...
Placentas of obese women have low mitochondrial β-oxidation fatty acids (FA) and accumulate lipids in late pregnancy. This creates a lipotoxic environment, impairing placental efficiency. We hypothesized that FA metabolism is impaired with obesity from early assessed expression key regulators first trimester placentas lean women. Maternal fasting triglyceride insulin levels were measured plasma collected at the time procedure. Expression genes associated oxidation (FAO; ACOX1, CPT2, AMPKα),...
Abstract Maximum lifespan of a species is the oldest that individuals can survive, reflecting genetic limit longevity in an ideal environment. Here we report methylation-based models accurately predict maximum (r=0.89), gestational time (r=0.96), and age at sexual maturity (r=0.87), using cytosine methylation patterns collected from over 12,000 samples derived 192 mammalian species. Our epigenetic predictor corroborated extended growth hormone receptor knockout mice rapamycin treated mice....
Efforts to decrease the risk of developing metabolic complications pregnancy such as gestational diabetes (GDM) through lifestyle intervention (decreasing excessive weight gain (GWG)) during have met with limited success.The purpose this study was determine relationship between longitudinal changes in weight/body composition and insulin sensitivity response women normal glucose tolerance (NGT) those who developed GDM.We conducted a secondary analysis prospective cohort before conception...
Abstract Abnormally increased angiotensin II activity related to maternal angiotensinogen (AGT) genetic variants, or aberrant receptor activation, is associated with small-for-gestational-age babies and abnormal uterine spiral artery remodeling in humans. Our group studies a murine AGT gene titration transgenic (TG; 3-copies of the gene) model, which has 20% increase expression mimicking common human variant (A[−6]G) intrauterine growth restriction (IUGR) pathology. We hypothesized that...
Objective: Fetal fatty acid (FA) delivery is ultimately controlled by placental transport. Focus has been the maternal-placental interface, but regulation at feto-placental interface unknown.Methods: Placental macrovascular endothelial cells (EC) (n = 4/group) and trophoblasts (TB) 5/group) were isolated from lean (pregravid BMI <25 kg/m2) obese (body mass index (BMI) > 30) women. Fatty transporters FAT/CD36, FABPpm, FATP4, FABP 3, 4 5, PLIN2 PPARα, δ, γ expression, was measured in EC TB....
Long chain polyunsaturated fatty acids (LCPUFAs), such as the omega-6 (n-6) arachidonic acid (AA) and n-3 docosahexanoic (DHA), have a vital role in normal fetal development placental function. Optimal supply of these LCPUFAs to fetus is critical for improving birth outcomes preventing programming metabolic diseases later life. Although not explicitly required/recommended, many pregnant women take LCPUFA supplements. Oxidative stress can cause undergo lipid peroxidation, creating toxic...