Carrie J. Finno
A5045863299- Genetic and phenotypic traits in livestock
- Veterinary Equine Medical Research
- Neurological diseases and metabolism
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Muscle metabolism and nutrition
- Genomics and Phylogenetic Studies
- Plant Toxicity and Pharmacological Properties
- Cardiomyopathy and Myosin Studies
- Muscle Physiology and Disorders
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Exercise and Physiological Responses
- Inflammatory Myopathies and Dermatomyositis
- Antioxidant Activity and Oxidative Stress
- Toxoplasma gondii Research Studies
- Peroxisome Proliferator-Activated Receptors
- Plant and fungal interactions
- Genomics and Chromatin Dynamics
- Hereditary Neurological Disorders
- Parasitic Infections and Diagnostics
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- RNA Research and Splicing
- Cardiovascular Effects of Exercise
University of California, Davis
2016-2025
University of Kentucky
2024
University of Agriculture in Krakow
2024
University of Nebraska–Lincoln
2024
British Veterinary Association
2023
National Institutes of Health
2020
Veterinary Medical Teaching Hospital
2006-2020
Office of Dietary Supplements
2020
In-Q-Tel
2016
University of Minnesota
2003-2015
Abstract Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation pan-tissue epigenetic clocks. Here, we demonstrate development universal pan-mammalian clocks, 11,754 arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate age with high accuracy ( r > 0.96). Age deviations correlate human mortality risk, mouse somatotropic...
Using DNA methylation profiles (
To date, genome-scale analyses in the domestic horse have been limited by suboptimal single nucleotide polymorphism (SNP) density and uneven genomic coverage of current SNP genotyping arrays. The recent availability whole genome sequences has created opportunity to develop a next generation, high-density equine array. Using sequence from 153 individuals representing 24 distinct breeds collated genomics community, we cataloged over 23 million de novo discovered genetic variants. Leveraging...
ABSTRACT Aging is often perceived as a degenerative process resulting from random accrual of cellular damage over time. Despite this, age can be accurately estimated by epigenetic clocks based on DNA methylation profiles almost any tissue the body. Since such pan-tissue have been successfully developed for several different species, we hypothesized that one build pan-mammalian measure in all mammalian species. To address generated data using 11,754 arrays, each profiling up to 36 thousand...
The cause of immune-mediated myositis (IMM), characterized by recurrent, rapid-onset muscle atrophy in Quarter Horses (QH), is unknown. histopathologic hallmark IMM lymphocytic infiltration myofibers. purpose this study was to identify putative functional variants associated with equine IMM. A genome-wide association (GWA) performed on 36 QHs and 54 breed matched unaffected from the same environment using Equine SNP50 SNP70 genotyping arrays. mixed model analysis identified nine SNPs within...
Abstract Effective conservation and management of threatened wildlife populations require an accurate assessment age structure to estimate demographic trends population viability. Epigenetic aging models are promising developments because they individual with high accuracy, accurately predict in related species, do not invasive sampling or intensive long-term studies. Using blood biopsy samples from known plains zebras ( Equus quagga ), we model epigenetic using two approaches: the clock...
Cyathostomins are ubiquitous equine nematodes. Infection can result in larval cyathostominosis due to mass emergence. Although faecal egg count (FEC) tests provide estimates of shedding, these correlate poorly with burden and no information on mucosal/luminal larvae. Previous studies describe a serum IgG(T)-based ELISA (CT3) that exhibits utility for detection cyathostomins. Here, this is optimised/validated commercial application using sera from horses which data were available....
Equine neuroaxonal dystrophy/degenerative myeloencephalopathy (eNAD/EDM) is a neurodegenerative disease that primarily affects young, genetically predisposed horses are deficient in vitamin E. NAD/EDM has not previously been documented Gypsy Vanner (GVs).
Horses obtain vitamin E, an essential nutrient for neuromuscular health, through green pasture. Vitamin E dietary deficiencies can lead to diseases such as equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy, motor neuron disease and deficient myopathy. Some horses are genetically susceptible developing these diseases, but not all that exhibit clinical signs. supplementation is effective at slowing or halting signs of some the damage usually irreversible, except in case...
Equine spinal neurodegenerative conditions are frequently encountered in sport and racing horses may be career-ending diagnoses. To further define the spatial transcriptomic landscape of equine dorsal root ganglia (DRG) healthy adult horses, we investigated gene expression differences distinct DRG regions using GeoMx Digital Spatial Profiling from NanoString. Four human cell markers demonstrated high fidelity for cells; microtubule-associated protein 2 (MAP2), myelin basic (MBP), allograft...
Abstract Anhidrosis is defined as a decreased or absent ability to sweat in response heat and exercise. In horses, this condition can increase the risk of life‐threatening hyperthermia. A prior study has suggested that equine anhidrosis associated with missense variant (rs68643109) Potassium Voltage‐Gated Channel Subfamily E Regulatory Subunit 4 ( KCNE4 ) gene. This project aimed validate association population well‐phenotyped horses determine allele frequency publicly available whole‐genome...
The Functional Annotation of Animal Genomes (FAANG) consortium aims to annotate animal genomes across species, and work in the horse has substantially contributed that goal. As part this initiative, chromatin immunoprecipitation with sequencing (ChIP-seq) was performed identify histone modifications corresponding enhancers (H3K4me1), promoters (H3K4me3), activators (H3K27ac), repressors (H3K27me3) eight tissues from two Thoroughbred stallions: adipose, parietal cortex, heart, lamina, liver,...
Abstract Objective —To characterize onset and clinical signs of polysaccharide storage myopathy (PSSM) in a welldefined population affected Quarter Horses, identify risk factors for PSSM, determine compliance owners to dietary exercise recommendations, evaluate the efficacy recommendations. Animals —40 Horses with PSSM 37 unaffected control horses. Procedure s—Owners horses completed retrospective questionnaire concerning their horse's condition. Results —Between horses, no significant...
To describe epidemiological, clinical, and pathological features of neuroaxonal dystrophy in Quarter Horses (QHs) on a single farm.Prospective case series. Animals-148 horses.Neurologic, pathological, toxicological evaluations were completed selected neurologically affected horses over 2-year period. Descriptive statistical analysis was performed.87 QHs 1 QH-crossbred horse affected. Most (50/88 [56.8%]) to 2 years old (median age, [range, months 34 years]). Neurologic deficits included...
The Functional Annotation of Animal Genomes (FAANG) project aims to identify genomic regulatory elements in both sexes across multiple stages development domesticated animals. This study represents the first stage FAANG for horse, Equus caballus. A biobank 80 tissue samples, two cell lines and six body fluids was created from adult Thoroughbred mares. Ante-mortem assessments included full physical examinations, lameness, ophthalmologic neurologic evaluations. Complete blood counts serum...