A5044363243- Gut microbiota and health
- Artificial Intelligence in Law
- Multi-Agent Systems and Negotiation
- Genetic and phenotypic traits in livestock
- Semantic Web and Ontologies
- Meat and Animal Product Quality
- Animal Virus Infections Studies
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Clostridium difficile and Clostridium perfringens research
- Ruminant Nutrition and Digestive Physiology
- Helminth infection and control
- Plant and fungal interactions
- Veterinary Equine Medical Research
- Diet and metabolism studies
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Fatty Acid Research and Health
- Genetics and Physical Performance
- Muscle metabolism and nutrition
- Metabolomics and Mass Spectrometry Studies
- Genetic Mapping and Diversity in Plants and Animals
- Molecular Biology Techniques and Applications
- Respiratory viral infections research
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
École Nationale Vétérinaire de Toulouse
2022-2025
Interaction Hôtes Agents Pathogènes
2021-2025
Génétique Animale et Biologie Intégrative
2015-2024
Université de Toulouse
2022-2024
Institut National Polytechnique de Toulouse
2024
Département Santé Animale
2023
AgroParisTech
2013-2022
Université Paris-Saclay
2015-2022
Infectiologie Animale et Santé Publique
2021
Summary Early bacterial colonization and succession within the gastrointestinal tract has been suggested to be crucial in establishment of specific microbiota composition shaping host phenotype. Here, dynamics faecal microbiomes were studied for 31 healthy piglets across five age strata (days 14, 36, 48, 60 70 after birth) together with their mothers. Faecal microbiome was assessed by 16 S rRNA gene 454‐pyrosequencing. B acteroidetes F irmicutes predominant phyla present at each age. For all...
Forty-eight bulls (335 +/- 8.6 kg of initial BW) were randomly assigned to 4 glycerin levels (0, 4, 8, and 12% concentrate DM) with the objective evaluating effects supplementation on performance, ruminal fermentation, metabolism, carcass meat quality in Holstein fed high-concentrate diets. Concentrates formulated be isonitrogenous isocaloric (assuming a ME content 3.47 Mcal/kg DM). Concentrate straw for ad libitum intake. Bull BW feed consumption recorded monthly. Additionally, rumen blood...
New advances in high-throughput technologies have allowed for the massive analysis of genomic data, providing new opportunities characterization transcriptome architectures. Recent studies pigs employed RNA-Seq to explore different tissues a reduced number animals. The main goal this study was identification differentially-expressed genes liver Iberian x Landrace crossbred showing extreme phenotypes intramuscular fatty acid composition using RNA-Seq. transcriptomes two female groups (H and...
To date, genome-scale analyses in the domestic horse have been limited by suboptimal single nucleotide polymorphism (SNP) density and uneven genomic coverage of current SNP genotyping arrays. The recent availability whole genome sequences has created opportunity to develop a next generation, high-density equine array. Using sequence from 153 individuals representing 24 distinct breeds collated genomics community, we cataloged over 23 million de novo discovered genetic variants. Leveraging...
Abstract Mitigation of greenhouse gas emissions is relevant for reducing the environmental impact ruminant production. In this study, rumen microbiome from Holstein cows was characterized through a combination 16S rRNA gene and shotgun metagenomic sequencing. Methane production (CH 4 ) dry matter intake (DMI) were individually measured over 4–6 weeks to calculate CH yield y = /DMI) per cow. We implemented clustering, multivariate mixed model analyses identify set operational taxonomic unit...
Abstract Background Gut dysbiosis has been associated with colorectal cancer (CRC), the third most prevalent in world. This study compares microbiota taxonomic and abundance results obtained by 16S rRNA gene sequencing (16S) whole shotgun metagenomic to investigate their reliability for bacteria profiling. The experimental design included 156 human stool samples from healthy controls, advanced (high-risk) lesion patients (HRL), CRC cases, each sample sequenced using both methods. We...
Horses are mainly housed in individual boxes. This housing system is reported to be highly detrimental with regard welfare and could trigger the expression of four behavioural indicators a compromised state: stereotypies, aggressiveness toward humans, unresponsiveness environment, stress-related behaviours. The aim this study was identify management factors that alleviate effects boxes on welfare. A total 187 horses were observed over 50 days by scan sampling. impact 12 investigated three...
Weaning has been described as one of the most stressful events in life horses. Given importance interaction between gut-brain axis and gut microbiota under stress, we evaluated (i) effect two different weaning methods on composition across time (ii) how shifts after affect host. A total 34 foals were randomly subjected to a progressive (P) or an abrupt (A) method. In P method, mares separated from at progressively increasing intervals every day, starting five minutes during fourth week prior...
Gastrointestinal strongyles are a major threat to horses' health and welfare. Given that inhabit the same niche as gut microbiota, they may interact with each other. These beneficial or detrimental interactions unknown in horses could partly explain contrasted susceptibility infection between individuals. To address these questions, an experimental pasture trial 20 worm-free female Welsh ponies (10 susceptible (S) 10 resistant (R) parasite infection) was implemented for five months. Fecal...
Abstract We simultaneously measured the fecal microbiota and multiple environmental host-related variables in a cohort of 185 healthy horses reared similar conditions during period eight months. The pattern rare bacteria varied from host to was largely different between two time points. Among suite examined, equitation factors were highly associated with gut variability, evoking relationship high levels physical mental stressors. Behavioral indicators that pointed toward compromised welfare...
The nature and strength of interactions entertained among helminths their host gut microbiota remain largely unexplored. Using 40 naturally infected Welsh ponies, we tracked the microbiota-cyathostomin temporal dynamics stability before following anthelmintic treatment associated blood transcriptomic response. High shedders harbored 14 species cyathostomins, dominated by Cylicocyclus nassatus. They exhibited a highly diverse dynamic microbiota, with butyrate-producing Clostridia likely...
Abstract The adaptive response to extreme endurance exercise might involve transcriptional and translational regulation by microRNAs (miRNAs). Therefore, the objective of present study was perform an integrated analysis blood transcriptome miRNome (using microarrays) in horse before after a 160 km competition. A total 2,453 differentially expressed genes 167 were identified when comparing pre- post-ride samples. We used hypergeometric test its generalization gain better understanding...
Understanding gut microbiota similarities and differences across breeds in horses has the potential to advance approaches aimed at personalized microbial modifications, particularly those involved improving sport athletic performance. Here, we explore whether faecal composition based on 16S ribosomal RNA gene sequencing varies six different two time points 8 months apart within a cohort of 189 healthy cared for under similar conditions. Lusitano presented smallest Hanoverians greatest...
Abstract Elite horse athletes that live in individual boxes and train compete for hours experience long-term physical mental stress compromises animal welfare alters the gut microbiota. We therefore assessed if a temporary period out to pasture with conspecifics could improve turn, favorably affect intestinal microbiota composition. A total of 27 were monitored before after 1.5 months pasture, their fecal behavior profiles compared those 18 horses kept boxes. The overall diversity...
Fifty-four Holstein bulls were blocked by initial BW (301 +/- 7.4 kg) and randomly assigned to 6 treatments following a 3 x 2 factorial arrangement, with concentrate lipid levels (5, 8, 11% of DM) sources (whole canola seed whole linseed), the objective evaluating possibility increasing content n-3 fatty acids in meat. Concentrates (mostly corn meal) isonitrogenous isocaloric. Concentrate straw both fed ad libitum. Animal was recorded every wk, feed consumption weekly. Ruminal pH VFA...
Endurance horses are able to run at more than 20 km/h for 160 km (in bouts of 30-40 km). This level performance is based on intense aerobic metabolism, effective body heat dissipation and the ability endure painful exercise. The known heritabilities endurance exercise-related physiological traits in Arabian suggest that adaptation extreme exercise influenced by genetic factors. objective present genome-wide association study (GWAS) was identify single nucleotide polymorphisms (SNPs) related...