A5016374591- Veterinary Equine Medical Research
- Sports Performance and Training
- Muscle metabolism and nutrition
- Winter Sports Injuries and Performance
- Exercise and Physiological Responses
- Genetics and Physical Performance
- Mechanics and Biomechanics Studies
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Balance, Gait, and Falls Prevention
- Pharmacological Effects and Assays
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Cerebral Palsy and Movement Disorders
- Molecular Biology Techniques and Applications
- Sports injuries and prevention
- Cardiovascular Effects of Exercise
- Musculoskeletal pain and rehabilitation
- Muscle Physiology and Disorders
- Meat and Animal Product Quality
- Animal Behavior and Welfare Studies
- Genetic Mapping and Diversity in Plants and Animals
- Lower Extremity Biomechanics and Pathologies
- Effects of Environmental Stressors on Livestock
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
1990-2024
Université Paris-Saclay
2016-2024
Génétique Animale et Biologie Intégrative
2015-2024
AgroParisTech
2016-2024
Laboratoire d'Analyses Génétiques pour les Espèces Animales
2023
Université d'Évry Val-d'Essonne
2004-2016
Institut National de la Recherche Agronomique
1995-2014
Inserm
2008-2014
Genopole (France)
2006-2014
PhysioPathologie des Adaptations Nutritionnelles
2014
Background Because of the central functions mitochondria in providing metabolic energy and initiating apoptosis on one hand role that microRNA (miRNA) play gene expression, we hypothesized some miRNA could be present for post-transcriptomic regulation by RNA interference. We intend to identify localized isolated from human skeletal primary muscular cells. Methodology/Principal Findings To investigate potential origin mitochondrial miRNA, in-silico searched candidates mtDNA. Twenty five...
To date, genome-scale analyses in the domestic horse have been limited by suboptimal single nucleotide polymorphism (SNP) density and uneven genomic coverage of current SNP genotyping arrays. The recent availability whole genome sequences has created opportunity to develop a next generation, high-density equine array. Using sequence from 153 individuals representing 24 distinct breeds collated genomics community, we cataloged over 23 million de novo discovered genetic variants. Leveraging...
The horse is central to many Indigenous cultures across the American Southwest and Great Plains. However, when how horses were first integrated into lifeways remain contentious, with extant models derived largely from colonial records. We conducted an interdisciplinary study of assemblage historic archaeological remains, integrating genomic, isotopic, radiocarbon, paleopathological evidence. Archaeological modern North show strong Iberian genetic affinities, later influx British sources, but...
Abstract Horses revolutionized human history with fast mobility 1 . However, the timeline between their domestication and widespread integration as a means of transport remains contentious 2–4 Here we assemble collection 475 ancient horse genomes to assess period when these animals were first reshaped by agency in Eurasia. We find that reproductive control modern domestic lineage emerged around 2200 bce , through close-kin mating shortened generation times. Reproductive following severe...
The family of long noncoding mitochondrial RNAs (ncmtRNAs), comprising sense (SncmtRNA), and antisense (ASncmtRNA-1 ASncmtRNA-2) members, are differentially expressed according to cell proliferative status; SncmtRNA is in all proliferating cells, while ASncmtRNAs normal but downregulated tumor cells. ASncmtRNA knockdown with an oligonucleotide induces massive apoptosis lines, without affecting healthy Apoptotic death preceded by proliferation blockage, suggesting that these transcripts...
The purpose of this study was to compare the velocity-dependent changes in stride length and frequency horses performing same incremental exercise test first on a track with rider then treadmill 0 3.5% slope successively. Seven French saddle undertook which consisted 5 stages increasing speed for 3 min each 1 rest between stage (1.6, 4.2, 8.3, 9.2 10 m/s). were recorded by use video camera, tapes analysed regard gait parameters. At 1.6, m/s, frequencies significantly (p < 0.01) greater...
Summary A greater knowledge of the biomechanics is necessary in equine orthopaedics, therapeutics, farriery and for selection athletic horses. The purpose this study was to determine normal distribution vertical component hoof force using a measuring boot. measurements were carried out 20 sound horses walking trotting on straight hard track. horseshoe, attached foot with boot, provided continuous recording forces at four locations hoof. For each location, computer program produced curves...
Abstract The adaptive response to extreme endurance exercise might involve transcriptional and translational regulation by microRNAs (miRNAs). Therefore, the objective of present study was perform an integrated analysis blood transcriptome miRNome (using microarrays) in horse before after a 160 km competition. A total 2,453 differentially expressed genes 167 were identified when comparing pre- post-ride samples. We used hypergeometric test its generalization gain better understanding...
Falls are common in the elderly, and potentially result injury disability. Thus, preventing falls as soon possible older adults is a public health priority, yet there no specific marker that predictive of first fall onset. We hypothesized gait features should be most relevant variables for predicting fall. Clinical baseline characteristics (e.g., gender, cognitive function) were assessed 259 home-dwelling people aged 66 to 75 had never fallen. Likewise, global kinetic behavior was recorded...
Summary Dressage is one of the Olympic equestrian sports practiced in several countries using different horse breeds. Specific characteristics walk, trot and canter are required for dressage. It has been assumed that some these traits could be selected genetically contribute to dressage performance. The purpose this study was compare conformation young horses breeds used A total 142 age 3 years were classified into groups (German, French Spanish saddle horses) tested same procedure. skeletal...
Endurance horses are able to run at more than 20 km/h for 160 km (in bouts of 30-40 km). This level performance is based on intense aerobic metabolism, effective body heat dissipation and the ability endure painful exercise. The known heritabilities endurance exercise-related physiological traits in Arabian suggest that adaptation extreme exercise influenced by genetic factors. objective present genome-wide association study (GWAS) was identify single nucleotide polymorphisms (SNPs) related...
Endurance exercise in horses requires adaptive processes involving physiological, biochemical, and cognitive-behavioral responses an attempt to regain homeostasis. We hypothesized that the identification of relationships between blood metabolome, transcriptome, miRNome during endurance could provide significant insights into molecular response exercise. For this reason, serum metabolome whole-blood transcriptome data were obtained from ten before after a 160 km competition. global regulatory...
An integrated analysis of gut microbiota, blood biochemical and metabolome in 52 endurance horses was performed. Clustering by microbiota revealed the existence two communities mainly driven diet as host properties showed little effect. Community 1 presented lower richness diversity, but higher dominance rarity species, including some pathobionts. Moreover, its composition tightly linked to metabolites related lipid metabolism glycolysis at basal time. Despite fiber intake, community type...
The purpose of this study was to compare the damping effect 16 types shoeing by measuring hoof acceleration parameters on two trotting horses. At impact, maximal deceleration had extreme values such as 188 m/s<sup>2</sup>(± 55) for most combination (p < 0.01) and 746 m/s<sup>2</sup> (± 14) steel shoe (mean = 551 ± 125). After shock, exposed a mean vibrating at 418 Hz 84) which progressively damped in 37.3 ms 10.5). According these results, ability different...
Summary An accelerometric device was developed for evaluating the gait of young horses in field situations. Some measurements and data analysis were made to show its potential applications analysis. The transducers consisted two accelerometers measuring acceleration along longitudinal dorso‐ventral axes horses. They put into a leather pocket applied over sternum by means an elastic girth fastened onto horse. This belt connected light weight radio telemetric system. signals transmitted...
The purpose of this study was to demonstrate the relationships between jumping technique and dorsoventral acceleration measured at sternum. Eight saddle horses various abilities competed on a selective experimental show course including 14 obstacles. An accelerometric belt fastened onto thorax continuously during course. At each jump, 11 locomotor parameters (acceleration peaks, durations stride frequency) were obtained from acceleration-time curves. type obstacle significantly influenced...
Erythropoietin (EPO) is known to improve exercise performance by increasing oxygen blood transport and thus inducing a higher maximum uptake (VO2max). Furthermore, treatment with (or overexpression of) EPO induces protective effects in several tissues, including the myocardium. However, it not whether exerts this effect when present at physiological levels. Given that receptors have been identified skeletal muscle, we hypothesized may direct, on tissue. Thus, objectives of study were confirm...
During long distance endurance races, horses undergo high physiological and metabolic stresses. The adaptation processes involve the modulation of energetic pathways in order to meet energy demand. aims were evaluate effects exercise on plasma metabolomic profiles investigate relationships with individual horse performances. analyzed using non–dedicated methodology, NMR spectroscopy statistical multivariate analysis. advantage this method is several at same time a single sample. plasmas...
MiRNAs regulate multiple genes at the post-transcriptional level and therefore play an important role in many biological processes. It has been suggested that miRNA exported outside cells contribute to inter-cellular communication. Consequently, circulating miRNAs are of particular interest promising biomarkers for diseases. The number annotated horse genome is much lower compared model organisms like human mouse. We aimed identify novel equine tissue types breed serum. analysed 71 small...