Antoine Fages
A5087678385- Genetic diversity and population structure
- Archaeology and ancient environmental studies
- Forensic and Genetic Research
- Genetic and phenotypic traits in livestock
- Wildlife Ecology and Conservation
- Pluripotent Stem Cells Research
- Eurasian Exchange Networks
- Animal Diversity and Health Studies
- Environmental Philosophy and Ethics
- Ecology and biodiversity studies
- CRISPR and Genetic Engineering
- Genomics and Phylogenetic Studies
- Environmental DNA in Biodiversity Studies
- Evolution and Paleontology Studies
- Forensic Anthropology and Bioarchaeology Studies
- Ancient and Medieval Archaeology Studies
- Veterinary Equine Medical Research
- Archaeology and Historical Studies
- Animal Behavior and Reproduction
- Pleistocene-Era Hominins and Archaeology
- Fish Ecology and Management Studies
- Aquatic Ecosystems and Biodiversity
- Evolution and Genetic Dynamics
- Forest Ecology and Biodiversity Studies
- Developmental Biology and Gene Regulation
University of Basel
2021-2025
Université Toulouse III - Paul Sabatier
2016-2024
Centre National de la Recherche Scientifique
2016-2024
Centre d'Anthropobiologie et de Génomique de Toulouse
2021-2024
Université de Toulouse
2016-2022
AMIS - Laboratoire d'anthropologie moléculaire et imagerie de synthèse
2016-2020
University of Copenhagen
2015-2019
Lundbeck Foundation
2019
Natural History Museum Aarhus
2015-2018
Natural History Museum of Denmark
2017-2018
Revisiting the origins of modern horses The domestication was very important in history humankind. However, ancestry and location timing their emergence remain unclear. Gaunitz et al. generated 42 ancient-horse genomes. Their source samples included Botai archaeological site Central Asia, considered to include earliest domesticated horses. Unexpectedly, were ancestors not domestic horses, but rather Przewalski's Thus, contrast current thinking on horse domestication, may have been other,...
Horse domestication revolutionized warfare and accelerated travel, trade, the geographic expansion of languages. Here, we present largest DNA time series for a non-human organism to date, including genome-scale data from 149 ancient animals 129 genomes (≥1-fold coverage), 87 which are new. This extensive dataset allows us assess modern legacy past equestrian civilizations. We find that two extinct horse lineages existed during early domestication, one at far western (Iberia) other eastern...
Abstract Domestication of horses fundamentally transformed long-range mobility and warfare 1 . However, modern domesticated breeds do not descend from the earliest domestic horse lineage associated with archaeological evidence bridling, milking corralling 2–4 at Botai, Central Asia around 3500 bc 3 Other longstanding candidate regions for domestication, such as Iberia 5 Anatolia 6 , have also recently been challenged. Thus, genetic, geographic temporal origins remained unknown. Here we...
Ancient genomics of horse domestication The the was a seminal event in human cultural evolution. Librado et al. obtained genome sequences from 14 horses Bronze and Iron Ages, about 2000 to 4000 years ago, soon after domestication. They identified variants determining coat color genes selected during process. could also see evidence admixture with archaic demography process, which included accumulation deleterious variants. appears have undergone different type process than animals that were...
Donkeys transformed human history as essential beasts of burden for long-distance movement, especially across semi-arid and upland environments. They remain insufficiently studied despite globally expanding providing key support to low- middle-income communities. To elucidate their domestication history, we constructed a comprehensive genome panel 207 modern 31 ancient donkeys, well 15 wild equids. We found strong phylogeographic structure in donkeys that supports single Africa ~5000 BCE,...
The horse is central to many Indigenous cultures across the American Southwest and Great Plains. However, when how horses were first integrated into lifeways remain contentious, with extant models derived largely from colonial records. We conducted an interdisciplinary study of assemblage historic archaeological remains, integrating genomic, isotopic, radiocarbon, paleopathological evidence. Archaeological modern North show strong Iberian genetic affinities, later influx British sources, but...
Abstract Horses revolutionized human history with fast mobility 1 . However, the timeline between their domestication and widespread integration as a means of transport remains contentious 2–4 Here we assemble collection 475 ancient horse genomes to assess period when these animals were first reshaped by agency in Eurasia. We find that reproductive control modern domestic lineage emerged around 2200 bce , through close-kin mating shortened generation times. Reproductive following severe...
High-throughput sequencing has dramatically fostered ancient DNA research in recent years. Shotgun sequencing, however, does not necessarily appear as the best-suited approach due to extensive contamination of samples with exogenous environmental microbial DNA. capture-enrichment methods represent cost-effective alternatives that increase focus on endogenous fraction, whether it is from mitochondrial or nuclear genomes, parts thereof. Here, we explored experimental parameters could impact...
Behavior is critical for animal survival and reproduction, possibly diversification evolutionary radiation. However, the genetics behind adaptive variation in behavior are poorly understood. In this work, we examined a fundamental widespread behavioral trait, exploratory behavior, one of largest radiations on Earth, cichlid fishes Lake Tanganyika. By integrating quantitative data from 57 species (702 wild-caught individuals) with high-resolution ecomorphological genomic information, show...
Cell type repertoires have expanded extensively in metazoan animals, with some clade-specific cells being crucial to evolutionary success. A prime example are the skeletogenic of vertebrates. Depending on anatomical location, these originate from three different precursor lineages, yet they converge developmentally towards similar cellular phenotypes. Furthermore, their 'skeletogenic competency' arose at distinct timepoints, thus questioning what extent skeletal body parts rely truly...
Diet specialisation is a main driver of diversification in many adaptive radiations. Therefore, identifying diet items essential to characterise trophic specialisations and understand the dynamics dietary adaptations. In this study, we explored niches 56 species from radiation cichlid fishes Lake Tanganyika, encompassing all major phylogenetic lineages feeding specialisations. We employed metagenomic sequencing approach identify food sources investigated at high taxonomic resolution, over...
The Silk Road was an important trade route that channeled goods, people, plants, animals, and ideas across the continental interior of Eurasia, fueling biotic exchange key social developments Old World. Nestled between Pamir Alay ranges at a baseline elevation nearly 3000m, Kyrgyzstan's high Valley forms wide geographic corridor comprised one primary channels ancient Road. Recent archaeological survey reveals millennia-long history pastoral occupation from early Bronze Age through Medieval...
Abstract Cell type repertoires have expanded extensively in metazoan animals, with some clade-specific cells being paramount to their evolutionary success. A prime example are the skeletogenic of vertebrates that form basis developing endoskeletons. Depending on anatomical location, these originate from three different embryonic precursor lineages – neural crest, somites, and lateral plate mesoderm yet they converge developmentally towards similar cellular phenotypes. Furthermore, gained...
Abstract Aim There has been recent interest in the origin and assembly of continental biotas based on densely sampled species‐level clades, however, studies from African freshwaters are few so that commonality macroevolutionary patterns processes among clades remain to be tested. Within Afrotropics, Congo Basin contains highest diversity riverine fishes, yet it is unclear how this fauna was assembled. To address this, diversification dynamics a radiation, we focus Mastacembelus spiny eels....
Alongside horses, donkeys and their first-generation hybrids represent members of the Equidae family known for social, economic symbolic importance in protohistoric historical France. However, relative respective roles different regions time periods are difficult to assess based on textual, iconographic archaeological evidence. This is both due incomplete, partial scattered sources difficulties accurately assign fragmentary remains at proper taxonomic level. DNA-based methods, however, allow...
Horses are gaining importance in European nature conservation management, for which usually so-called primitive breeds favored due to their claimed robustness. An increasingly popular breed, the Konik horse, is often said be direct descendent of alleged wild Tarpan. However, both descent from horses and existence Tarpan as a species highly debated. In this review, we scrutinized contemporary research historical sources suggest that its manmade myths hinder effective management. We did not...
Adaptations related to how nutrients are acquired and processed play a central role in the colonization of novel ecological niches and, therefore, organismal diversification. While evolution feeding structures has been studied extensively this context, nature dietary adaptations digestive tract remains largely unexplored. Here, we investigate cellular molecular basis massive radiation cichlid fishes Lake Tanganyika using comprehensive single-cell transcriptomic data derived from intestines...
Mules (Equus asinus x Equus caballus) represent first-generation hybrids between a female horse (mare) and male donkey (jack). They are generally considered to have first appeared north of the Alps with Roman influence, time period in which written iconographic sources support their key role for transport traction, both farming military. The archaeozoological evidence mules is, however, contentious as faunal assemblages difficult assign either parental species or based on morphometric data...