A5036542016- Pleistocene-Era Hominins and Archaeology
- Archaeology and ancient environmental studies
- Forensic Anthropology and Bioarchaeology Studies
- Wildlife Ecology and Conservation
- Cancer-related Molecular Pathways
- Cutaneous lymphoproliferative disorders research
- Forensic and Genetic Research
- Geology and Paleoclimatology Research
- Autoimmune Bullous Skin Diseases
- Animal Diversity and Health Studies
- Primate Behavior and Ecology
- Hedgehog Signaling Pathway Studies
- Hair Growth and Disorders
- Environmental DNA in Biodiversity Studies
- Amyotrophic Lateral Sclerosis Research
- Retinal Development and Disorders
- Fibroblast Growth Factor Research
- Vascular Tumors and Angiosarcomas
- Isotope Analysis in Ecology
- Wound Healing and Treatments
- Chronic Lymphocytic Leukemia Research
- Marine and environmental studies
- Poxvirus research and outbreaks
- Psoriasis: Treatment and Pathogenesis
- Hidradenitis Suppurativa and Treatments
University of Tübingen
2012-2024
Senckenberg Centre for Human Evolution and Palaeoenvironment
2024
Histoire Naturelle de l’Homme Préhistorique
2017-2018
Centre National de la Recherche Scientifique
2017-2018
Sorbonne Université
2017
Tokyo Women's Medical University
2017
Saiseikai Suita Hospital
1998-2001
Hyogo Medical University
1995-1996
Aichi Medical University
1989
Ancient DNA is revealing new insights into the genetic relationship between Pleistocene hominins and modern humans. Nuclear indicated Neanderthals as a sister group of Denisovans after diverging from However, closer affinity Neanderthal mitochondrial (mtDNA) to humans than has recently been suggested result gene flow an African source before 100,000 years ago. Here we report complete mtDNA archaic femur Hohlenstein-Stadel (HST) cave in southwestern Germany. HST carries deepest divergent...
Abstract Domestication of horses fundamentally transformed long-range mobility and warfare 1 . However, modern domesticated breeds do not descend from the earliest domestic horse lineage associated with archaeological evidence bridling, milking corralling 2–4 at Botai, Central Asia around 3500 bc 3 Other longstanding candidate regions for domestication, such as Iberia 5 Anatolia 6 , have also recently been challenged. Thus, genetic, geographic temporal origins remained unknown. Here we...
We measured autofluorescence of the macula with fluorophotometry to evaluate age-related changes in human retinal pigment epithelium. Examined this study were 35 aphakic eyes 25 patients, ranging age from 52 87 years, after uneventful intracapsular cataract extraction and 21 normal phakic 20 9 29 years. Autofluorescence at increased an age-dependent manner (r = 0.514; p less than 0.01) as follows: 15.0 ngEq/ml for sixth decade (n 1), 17.2 +/- 4.2 seventh 11), 21.3 3.6 eighth 16) 24.6 2.7...
This article presents a pilot experiment conducted to better understand how Middle Pleistocene hominins might have processed and exploited elephants using simple stone bone tools. The was in three phases: (1) production of small, flake-based tools, (2) butchery the lower hind-leg an Indian elephant, (3) manufacture tools from tibia. shows it is possible cut through elephant skin under four minutes small chipped-stone flakes; disarticulating astragalus tibia relatively easy, whereas other...
DNA hybridization-capture techniques allow researchers to focus their sequencing efforts on preselected genomic regions. This feature is especially useful when analysing ancient (aDNA) extracts, which are often dominated by exogenous environmental sources. Here, we assessed, for the first time, performance of hyRAD as an inexpensive and design-free alternative commercial capture protocols obtain authentic aDNA data from osseous remains. HyRAD relies double enzymatic restriction fresh...
Overexpression of cyclin D1 and p53 protein has been reported in many types malignant tumors.We investigated whether was detected immunohistochemically various tumors the skin, comparable with protein.Immunohistochemical staining applied to squamous cell carcinoma, melanoma fibrous histiocytoma kinds benign skin tumors.Cyclin positive only at same incidence as protein.Cyclin immunohistochemical may be a marker for tumors.
The systematic use of antlers and other osseous materials by modern humans marks a set cultural technological innovations in the early Upper Paleolithic, as is seen most clearly Aurignacian. Split-based points, which are one common tools, present throughout regions where Aurignacian documented. Using results from recent ongoing excavations at Geißenklösterle, Hohle Fels Vogelherd, we nearly tripled sample split-based points 31 to 87 specimens, thereby enhance our understanding economy...
Abstract Shifts in projectile technology potentially document human evolutionary milestones, such as adaptations for different environments and settlement dynamics. A relatively direct proxy is impact marks (PIM) on archaeological bones. Increasing awareness publication of experimental data sets have recently led to more identifications PIM various contexts, but diagnosing from other types bone-surface modifications, quantifying them, inferring point size material the bone lesions need...
Journal Article Coexpression of p21Waf1/Cip1 and p53 in sun‐exposed normal epidermis, but not neoplastic epidermis Get access S. INOHARA, INOHARA Department Dermatology Hyogo College Medicine, Nishinomiya, 663, Japan Search for other works by this author on: Oxford Academic Google Scholar K. KITAGAWA, KITAGAWA Y. KITANO British Dermatology, Volume 135, Issue 5, 1 November 1996, Pages 717–720, https://doi.org/10.1046/j.1365-2133.1996.d01-1068.x Published: 01 1996 history Accepted: 21 March