A5033297259- Fish biology, ecology, and behavior
- Genetic diversity and population structure
- Fish Biology and Ecology Studies
- Aquaculture disease management and microbiota
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Animal Behavior and Reproduction
- Fish Ecology and Management Studies
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- melanin and skin pigmentation
- Evolution and Genetic Dynamics
- Bat Biology and Ecology Studies
- Insect symbiosis and bacterial influences
- Insect-Plant Interactions and Control
- Hemiptera Insect Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neurobiology and Insect Physiology Research
- Animal Genetics and Reproduction
- Aquatic Ecosystems and Biodiversity
- RNA modifications and cancer
- Freshwater macroinvertebrate diversity and ecology
- Advanced biosensing and bioanalysis techniques
University of Cambridge
2020-2025
École Normale Supérieure de Lyon
2015-2019
Institut de Génomique Fonctionnelle de Lyon
2016-2019
Université Claude Bernard Lyon 1
2016-2019
Centre National de la Recherche Scientifique
2014-2019
Wellcome/Cancer Research UK Gurdon Institute
2018
University of Basel
2010-2016
École Normale Supérieure - PSL
2014
University of Lisbon
2010
Instituto Gulbenkian de Ciência
2008
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand molecular mechanisms underlying cichlid phenotypic diversity, we sequenced genomes transcriptomes five lineages African cichlids: Nile tilapia (Oreochromis niloticus), an ancestral lineage with low diversity; four members lineage: Neolamprologus brichardi/pulcher (older radiation, Lake Tanganyika), Metriaclima zebra (recent Malawi), Pundamilia nyererei (very recent...
Abstract The bed bug, Cimex lectularius , has re-established itself as a ubiquitous human ectoparasite throughout much of the world during past two decades. This global resurgence is likely linked to increased international travel and commerce in addition widespread insecticide resistance. Analyses C. sequenced genome (650 Mb) 14,220 predicted protein-coding genes provide comprehensive representation that are traumatic insemination, reduced chemosensory repertoire related obligate...
The origin of novel phenotypic characters is a key component in organismal diversification; yet, the mechanisms underlying emergence such evolutionary novelties are largely unknown. Here we examine egg-spots, an innovation most species-rich group cichlids, haplochromines, where these conspicuous male fin colour markings involved mating. Applying combination RNAseq, comparative genomics and functional experiments, identify two pigmentation genes, fhl2a fhl2b, show that especially more rapidly...
Abstract Background The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology excellent experimental tractability molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids blood-feeding bed bugs, we present the genome sequence comparative analyses centered on milkweed bug Oncopeltus fasciatus , seed feeder family Lygaeidae. Results 926-Mb is well represented by current assembly official gene set....
Rhagovelia apuruaque sp. nov. (Hemiptera: Heteroptera: Veliidae), from the commune of Régina, French Guiana, is described, illustrated, and compared with species salina group. Brachymetra albinervus (Amyot & Serville, 1843), B. lata Shaw, 1933, Limnogonus ignotus Drake Harris, 1934, Neogerris lubricus (White, 1879), Rheumatobates crassifemur esakii Schroeder, 1931 (Gerridae), Mesovelia mulsanti White, 1879 (Mesoveliidae), Microvelia longipes Uhler, 1894, M. mimula 1879, pulchella...
Fans enable water strider adaptation Genomes of closely related organisms are similar but contain variations that different phenotypes and lifestyles. The origin evolutionary innovations, such as insect wings bird feathers, poses a challenge to biology because the de novo emergence complex traits cannot easily be explained by natural selection. Water-walking Rhagovelia insects evolved propelling fan on middle leg is associated with life fast-flowing streams. Santos et al. discovered geisha...
Abstract Chromosomal inversions contribute to adaptive speciation by linking co-adapted alleles. Querying 1,375 genomes of the species-rich Malawi cichlid fish radiation, we discovered five large segregating in benthic subradiation that each suppress recombination over more than half a chromosome. Two were transferred from deepwater pelagic Diplotaxodon via admixture, while others established early deep clade. Introgression haplotypes lineages inside and outside radiation coincided with...
Abstract Epigenetic variation can alter transcription and promote phenotypic divergence between populations facing different environmental challenges. Here, we assess the epigenetic basis of diversification during early stages speciation. Specifically, focus on extent functional relevance DNA methylome in very young radiation Astatotilapia calliptera crater Lake Masoko, southern Tanzania. Our study focuses two lake ecomorphs that diverged approximately 1,000 years ago a population nearby...
ABSTRACT Vertebrate pigmentation patterns are amongst the best characterised model systems for studying genetic basis of adaptive evolution. The wealth available data on evolution allows analysis trends and quantitative testing evolutionary hypotheses. We employed Gephebase , a database variants associated with natural domesticated trait variation, to examine in how cis ‐regulatory coding mutations contribute vertebrate phenotypes, as well factors that favour one mutation type over other....
Behavior is critical for animal survival and reproduction, possibly diversification evolutionary radiation. However, the genetics behind adaptive variation in behavior are poorly understood. In this work, we examined a fundamental widespread behavioral trait, exploratory behavior, one of largest radiations on Earth, cichlid fishes Lake Tanganyika. By integrating quantitative data from 57 species (702 wild-caught individuals) with high-resolution ecomorphological genomic information, show...
Abstract The East African Rift Lakes, namely Lake Malawi, Victoria, and Tanganyika, host a remarkable diversity of cichlid fishes, representing one nature’s most striking vertebrate radiations. Despite rich phenotypic diversity, single nucleotide polymorphism (SNP)-based sequencing studies have revealed little sequence divergence between cichlids, with 0.1 to 0.25% pairwise within Malawi. These were based on aligning short reads linear reference genome, which ignores the contribution larger...
Part-time working can be beneficial for individual academics, and also academia as a whole. In addition to improving work-life balance well-being, the benefits of part-time include increased motivation, reduced burnout, workplaces that are more diverse inclusive. Here, six researchers who have experience discuss what individuals, employers funders do promote support in academia.
Abstract The evolution of convergent phenotypes is one the most interesting outcomes replicate adaptive radiations. Remarkable cases convergence involve thick‐lipped phenotype found across cichlid species flocks in E ast A frican G reat L akes. Unlike other forms cichlids, which are restricted to frica, also occurs elsewhere, for example C entral merican M idas ichlid assemblage. Here, we use an ecological genomic approach study function, and genetic basis this two independent radiations on...
The extreme diversity of cichlid fishes in East Africa helps to elucidate how and why organisms diversify.
Having conquered water surfaces worldwide, the semi-aquatic bugs occupy ponds, streams, lakes, mangroves, and even open oceans. The diversity of this group has inspired a range scientific studies from ecology evolution to developmental genetics hydrodynamics fluid locomotion. However, lack representative strider genome hinders our ability more thoroughly investigate molecular mechanisms underlying processes adaptation diversification within group. Here we report sequencing manual annotation...
Acquisition of new ecological opportunities is a major driver adaptation and species diversification [1Losos J.B. Lizards in an Evolutionary Tree: Ecology Adaptive Radiation Anoles. University California Press, 2009Crossref Google Scholar, 2Mayr E. Animal Species Evolution. Belknap Press Harvard 1963Crossref 3Schluter D. The Radiation. Oxford 2000Google 4Yoder Clancey Des Roches S. Eastman J.M. Gentry L. Godsoe W. Hagey T.J. Jochimsen Oswald B.P. Robertson J. et al.Ecological opportunity the...
Abstract Background East African cichlid fishes have diversified in an explosive fashion, but the (epi)genetic basis of phenotypic diversity these remains largely unknown. Although transposable elements (TEs) been associated with variation cichlids, little is known about their transcriptional activity and epigenetic silencing. We set out to bridge this gap understand interactions between TEs hosts. Results Here, we describe dynamic patterns TE expression gonads during early development....
Pesticide resistance is a major concern in natural populations and model trait to study adaptation. Despite the importance of this trait, dynamics its evolution ecological consequences remain largely unstudied. To fill gap, we performed experimental with replicated Caenorhabditis elegans exposed pesticide Levamisole during 20 generations. Exposure resulted decreased survival, fecundity male frequency, which declined from 30% zero. This was not due differential susceptibility males. Rather,...
The FoxP gene subfamily of transcription factors is defined by its characteristic 110 amino acid long DNA-binding forkhead domain and plays essential roles in vertebrate biology.Its four members, FoxP1-P4, have been extensively characterized functionally.FoxP1, FoxP2, FoxP4 are involved lung, heart, gut, central nervous system (CNS) development.FoxP3 necessary sufficient for the specification regulatory T cells (Tregs) adaptive immune system.In Drosophila melanogaster, silico predictions...
The hundreds of endemic species cichlid fishes in the East African Great Lakes Tanganyika, Malawi, and Victoria are a prime model system evolutionary biology. With five genomes currently being sequenced, eastern cichlids also represent forthcoming genomic for studies genotype-to-phenotype processes adaptive radiations. Here we report functional annotation comparative analyses transcriptome data sets two species, Astatotilapia burtoni Ophthalmotilapia ventralis, representatives modern...
Understanding the genetic basis of novel traits is a central topic in evolutionary biology. Two pigmentation phenotypes, egg-spots and blotches, emerged during rapid diversification East African cichlid fishes. Egg-spots are circular markings on anal fins hundreds derived haplochromine cichlids species, whereas blotches patches conspicuous fin with ill-defined boundaries that occur few species belong to basal lineages. Both play an important role breeding behavior this group Knowledge about...
Abstract Epigenetic variation modulates gene expression and can be heritable. However, knowledge of the contribution epigenetic divergence to adaptive diversification in nature remains limited. The massive evolutionary radiation Lake Malawi cichlid fishes displaying extensive phenotypic diversity despite extremely low sequence is an excellent system study epigenomic adaptation. Here, we present a comparative genome-wide methylome transcriptome study, focussing on liver muscle tissues...
The cichlid fishes comprise the largest extant vertebrate family and are quintessential example of rapid "explosive" adaptive radiations phenotypic diversification. Despite low genetic divergence, East African cichlids harbor a spectacular intra- interspecific morphological diversity, including hyper-variable, neural crest (NC)-derived traits such as coloration craniofacial skeleton. Although developmental basis these phenotypes has been investigated, understanding when, specifically how...
Naturalists have been fascinated for centuries by animal colors and color patterns. While widely studied at the adult stage, we know little about patterns in embryo. Here, study a trait consisting of coloration that is specific to embryo absent from postembryonic stages water striders (Gerromorpha). By combining developmental genetics with chemical phylogenetic analyses across broad sample species, uncovered mechanisms underlying emergence diversification embryonic this group insects. We...