A5091801860- RNA modifications and cancer
- Hemoglobinopathies and Related Disorders
- Chromosomal and Genetic Variations
- Animal Genetics and Reproduction
- Machine Learning in Healthcare
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- RNA Research and Splicing
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Fish Biology and Ecology Studies
- Genetic diversity and population structure
- Genomics and Rare Diseases
- Healthcare Technology and Patient Monitoring
- interferon and immune responses
- Molecular Biology Techniques and Applications
- Insect and Arachnid Ecology and Behavior
- Fungal and yeast genetics research
- Cancer-related molecular mechanisms research
- HIV Research and Treatment
- Neurobiology and Insect Physiology Research
- Genomic variations and chromosomal abnormalities
- Plant and animal studies
- Marine Bivalve and Aquaculture Studies
- Reproductive Biology and Fertility
King's College Hospital NHS Foundation Trust
2016-2024
King's College Hospital
2015
University of Oxford
2015
Genomics (United Kingdom)
2015
Broad Institute
2014
University of Lausanne
2007-2013
SIB Swiss Institute of Bioinformatics
2012-2013
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand molecular mechanisms underlying cichlid phenotypic diversity, we sequenced genomes transcriptomes five lineages African cichlids: Nile tilapia (Oreochromis niloticus), an ancestral lineage with low diversity; four members lineage: Neolamprologus brichardi/pulcher (older radiation, Lake Tanganyika), Metriaclima zebra (recent Malawi), Pundamilia nyererei (very recent...
Ionotropic glutamate receptors (iGluRs) are a highly conserved family of ligand-gated ion channels present in animals, plants, and bacteria, which best characterized for their roles synaptic communication vertebrate nervous systems. A variant subfamily iGluRs, the Receptors (IRs), was recently identified as new class olfactory fruit fly, Drosophila melanogaster, hinting at broader function this channel detection environmental, well intercellular, chemical signals. Here, we investigate origin...
Understanding the extent of genomic transcription and its functional relevance is a central goal in genomics research.However, detailed genomewide investigations transcriptome complexity major mammalian organs have been scarce.Here, using extensive RNA-seq data, we show that genome substantially more widespread testis than other across representative mammals.Furthermore, reveal meiotic spermatocytes especially postmeiotic round spermatids remarkably diverse transcriptomes, which explains...
The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant age-related diseases, particularly cancer. Here, we report sequencing comparative analysis of genome two transcriptomes from different populations. Our identifies genes under positive selection bowhead-specific mutations in linked cancer aging. In addition, identify gene gain loss involving associated with...
As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore the original transcriptional output, and resulting overexpression females then drove evolution inactivation (XCI). However, this model never directly tested patterns mechanisms dosage compensation across different mammals birds generally remain little understood....
Embryonic development in nonmammalian vertebrates depends entirely on nutritional reserves that are predominantly derived from vitellogenin proteins and stored egg yolk. Mammals have evolved new resources, such as lactation placentation, to nourish their developing early offspring. However, the evolutionary timing molecular events associated with this major phenotypic transition not known. By means of sensitive comparative genomics analyses simulations, we here show three ancestral...
The genome sequence of the ferret, a model human respiratory disease, enables research on influenza and cystic fibrosis. domestic ferret (Mustela putorius furo) is an important animal for multiple diseases. It considered 'gold standard' modeling virus infection transmission1,2,3,4. Here we describe 2.41 Gb draft assembly constituting 2.28 plus gaps. We annotated 19,910 protein-coding genes this using RNA-seq data from 21 tissues. characterized host response to two infections by analysis 42...
Abstract Background Gene duplication is the primary source of new genes with novel or altered functions. It known that duplicates may obtain these functional roles by evolving divergent expression patterns and/or protein functions after event. Here, using yeast ( Saccharomyces cerevisiae ) as a model organism, we investigate previously little considered mode for diversification duplicate genes: subcellular adaptation encoded proteins. Results We show 24-37% gene pairs derived from S....
The antiretroviral protein TRIM5alpha is known to have evolved different restriction capacities against various retroviruses, driven by positive Darwinian selection. However, how these specificities in the primate lineages not fully understood. Here we used ancestral resurrection estimate evolution of antiviral on lineage leading humans. We coding sequences from 24 primates for reconstruction using maximum-likelihood and Bayesian approaches. Ancestral were transduced into HeLa CRFK cells....
The aim is to develop and deploy an automated clinical alert system enhance patient care streamline healthcare operations. Structured unstructured data from multiple sources are used generate near real-time alerts for specific scenarios, with additional goal improve decision-making through accuracy reliability.
<title>Abstract</title> Background The aim is to develop and deploy an automated clinical alert system enhance patient care streamline healthcare operations. Structured unstructured data from multiple sources are used generate near real-time alerts for specific scenarios, with additional goal improve decision-making through accuracy reliability. Results was developed employing Apache NiFi Python scripts simplify processing pipelines flexibility in manipulation customization of alerts. A...