A5001500403- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Phylogenetic Studies
- Biomedical and Engineering Education
- Hydrocarbon exploration and reservoir analysis
- Bioinformatics and Genomic Networks
- RNA and protein synthesis mechanisms
- Geological and Geochemical Analysis
- Geochemistry and Geologic Mapping
- Genetic diversity and population structure
- RNA Research and Splicing
- Chromosomal and Genetic Variations
- Bacteriophages and microbial interactions
- Invertebrate Immune Response Mechanisms
- Microbial Natural Products and Biosynthesis
- Evolution and Paleontology Studies
- Ubiquitin and proteasome pathways
- Gene Regulatory Network Analysis
- Neurobiology and Insect Physiology Research
- RNA modifications and cancer
- Scientific Computing and Data Management
- Genomics and Chromatin Dynamics
- Geological and Geophysical Studies
- Protist diversity and phylogeny
- Fungal and yeast genetics research
- Evolution and Genetic Dynamics
European Molecular Biology Laboratory
2004-2024
European Molecular Biology Laboratory
2005-2019
Norwich Research Park
2014-2018
Earlham Institute
2017-2018
European Bioinformatics Institute
2008-2014
Sainsbury Laboratory
2014
Netherlands Bioinformatics Centre
2013-2014
Instituto Gulbenkian de Ciência
2013-2014
Centro de Investigación del Cáncer
2011-2013
SIB Swiss Institute of Bioinformatics
2013
Ionotropic glutamate receptors (iGluRs) are a highly conserved family of ligand-gated ion channels present in animals, plants, and bacteria, which best characterized for their roles synaptic communication vertebrate nervous systems. A variant subfamily iGluRs, the Receptors (IRs), was recently identified as new class olfactory fruit fly, Drosophila melanogaster, hinting at broader function this channel detection environmental, well intercellular, chemical signals. Here, we investigate origin...
Traditionally, protein-protein interactions were thought to be mediated by large, structured domains. However, it has become clear that the interactome comprises a wide range of binding interfaces with varying degrees flexibility, ranging from rigid globular domains disordered regions natively lack structure. Enrichment for disorder in highly connected hub proteins and its correlation organism complexity hint at functional importance regions. Nevertheless, they have not yet been extensively...
Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect the functionality cell. They particularly prominent cell signaling, controlling protein turnover directing localization. Given their importance, our understanding is surprisingly limited, largely as a result difficulty discovery, both experimentally computationally. The Eukaryotic Motif (ELM)...
The eukaryotic linear motif (ELM http://elm.eu.org) resource is a hub for collecting, classifying and curating information about short motifs (SLiMs). For >10 years, this has provided the scientific community with freely accessible guide to biology function of motifs. current version ELM contains ∼200 different classes over 2400 experimentally validated instances manually curated from >2000 publications. Furthermore, detailed motif-mediated interactions been annotated made available in...
Linear motifs are short segments of multidomain proteins that provide regulatory functions independently protein tertiary structure. Much intracellular signalling passes through modifications at linear motifs. Many thousands motif instances, most notably phosphorylation sites, have now been reported. Although clearly very abundant, difficult to predict de novo in sequences due the difficulty obtaining robust statistical assessments. The ELM resource http://elm.eu.org/ provides an expanding...
We have functionally analyzed the orthologous SRPN6 genes from Anopheles stephensi and gambiae using phylogenetic, molecular, reverse genetic, cell biological tools. The results strongly implicate in innate immune response against Plasmodium . This gene belongs to a mosquito-specific cluster including three additional serpins. expression is induced by Escherichia coli both rodent human malaria parasites. specifically expressed midgut cells invaded ookinetes circulating attached hemocytes....
The development of the endomembrane system was a major step in eukaryotic evolution. Membrane coats, which exhibit unique arrangement β-propeller and α-helical repeat domains, play key roles shaping membranes. Such proteins are likely to have been present ancestral eukaryote but cannot be detected prokaryotes using sequence-only searches. We used structure-based detection protocol search all proteomes for with this domain architecture. Apart from eukaryotes, we identified protein...
Nascent mRNAs produced by transcription in the nucleus are subsequently processed and packaged into mRNA ribonucleoprotein particles (messenger ribonucleoproteins (mRNPs)) before export to cytoplasm. Here, we have used poly(A)-binding protein Nab2 isolate mRNPs from yeast under conditions that preserve integrity. Upon Nab2-tandem affinity purification, several factors were co-enriched (Yra1, Mex67, THO-TREX) present of different size length. High-throughput sequencing co-precipitated RNAs...
The mountains of data thrusting from the new landscape modern high-throughput biology are irrevocably changing biomedical research and creating a near-insatiable demand for training in management manipulation mining analysis. Among life scientists, clinicians to environmental researchers, common theme is need not just use, gain familiarity with, bioinformatics tools resources but also understand their underlying fundamental theoretical practical concepts. Providing empower scientists handle...
Invasive bacteria are known to have captured and adapted eukaryotic host genes. They also readily acquire colonizing genes from other by horizontal gene transfer. Closely related species such as Helicobacter pylori hepaticus, which exploit different tissues, share almost none of their colonization The protease inhibitor alpha2-macroglobulin provides a major metazoan defense against invasive bacteria, trapping attacking proteases required parasites for successful invasion.Database searches...
Abstract Summary: Rapid technological advances have led to an explosion of biomedical data in recent years. The pace change has inspired new collaborative approaches for sharing materials and resources help train life scientists both the use cutting-edge bioinformatics tools databases how analyse interpret large datasets. A prototype platform such training was recently created by Bioinformatics Training Network (BTN). Building on this work, we a centralized portal courses, including...
"Scientific community" refers to a group of people collaborating together on scientific-research-related activities who also share common goals, interests, and values. Such communities play key role in many bioinformatics activities. Communities may be linked specific location or institute, involve working at different institutions locations. Education training is typically an important component these communities, providing valuable context which develop skills expertise, while...
The Tarcoola goldfield in central South Australia is hosted by the Paleoproterozoic Paxton Granite and Formation metasedimentary rocks. Both of these units are intruded narrow dikes Lady Jane Diorite, which considered to be part Gawler Range-Hiltaba volcano-plutonic event. Crosscutting relationships 40Ar/39Ar dating alteration sericite primary hornblende have demonstrated that veining, alteration, mineralization occurred synchronously with intrusion diorite at ~1580 Ma. Mineralization...
<ns4:p>In recent years, there has been an explosion in the popularity of hackathons — creative, participant-driven meetings at which software developers gather for intensive bout programming, often organized teams. Hackathons have tangible and intangible outcomes, such as code, excitement, learning, networking, so on, whose relative merits are unclear. For example, a frequent complaint is that code abandoned when hackathon ends, questions like, “which outcomes produced most reliably?” and,...
The Tarcoola Goldfield is one of several districts included in the recently proposed central Gawler gold province. Understanding genesis deposits this metallogenic province its infancy, and dating age alteration, mineralisation microdiorite dyke intrusions has been carried out at as a first step towards developing mineral‐systems models for At Tarcoola, four samples sericite from alteration well sample hornblende yield 40 Ar/ 39 Ar ages ca 1580 Ma. Geological petrological relationships...