A5066490454- Genetics, Bioinformatics, and Biomedical Research
- Scientific Computing and Data Management
- Genomics and Phylogenetic Studies
- Biomedical and Engineering Education
- Bioinformatics and Genomic Networks
- Research Data Management Practices
- Gene expression and cancer classification
- Insect-Plant Interactions and Control
- Aquatic Ecosystems and Biodiversity
- Genetic diversity and population structure
- Insect Pheromone Research and Control
- Insects and Parasite Interactions
- Ethics in Clinical Research
- Legume Nitrogen Fixing Symbiosis
- Biomedical Text Mining and Ontologies
- Cancer Genomics and Diagnostics
- Microbial Metabolic Engineering and Bioproduction
- Plant and animal studies
- vaccines and immunoinformatics approaches
- Evolution and Genetic Dynamics
- Academic Publishing and Open Access
- Innovation and Knowledge Management
- Meta-analysis and systematic reviews
- Insect and Arachnid Ecology and Behavior
- Mathematical and Theoretical Epidemiology and Ecology Models
MSB Medical School Berlin
2023
The University of Melbourne
2017-2020
Melbourne Bioinformatics
2017-2018
Norwich Research Park
2013-2017
Earlham Institute
2013-2017
EMBL Australia
2017
Australia Bioinformatics Resource
2017
European Bioinformatics Institute
2008-2014
Sainsbury Laboratory
2014
Instituto Gulbenkian de Ciência
2013-2014
The Molecular INTeraction database (MINT, http://mint.bio.uniroma2.it/mint/) aims at storing, in a structured format, information about molecular interactions (MIs) by extracting experimental details from work published peer-reviewed journals. At present the MINT team focuses curation on physical between proteins. Genetic or computationally inferred are not included database. Over past four years has undergone extensive revision. new version of is based completely remodeled structure, which...
Female sex pheromones attracting mating partners over long distances are a major determinant of reproductive isolation and speciation in Lepidoptera. Males can also produce but their study, particularly butterflies, has received little attention. A detailed comparison male butterflies with those female moths would reveal patterns conservation versus novelty the associated behaviours, biosynthetic pathways, compounds, scent-releasing structures receiving systems. Here we assess whether...
Scientific research relies on computer software, yet software is not always developed following practices that ensure its quality and sustainability. This manuscript does aim to propose new development best practices, but rather provide simple recommendations encourage the adoption of existing practices. Software promote better improves reproducibility reusability research. These are designed around Open Source values, practical suggestions contribute making source code more discoverable,...
Bioinformatics is now intrinsic to life science research, but the past decade has witnessed a continuing deficiency in this essential expertise. Basic data stewardship still taught relatively rarely education programmes, creating chasm between theory and practice, fuelling demand for bioinformatics training across all educational levels career roles. Concerned by this, surveys have been conducted recent years monitor computational needs worldwide. This article briefly reviews principal...
Rapid advances in the life sciences and related information technologies necessitate ongoing refinement of bioinformatics educational programs order to maintain their relevance. As discipline computational biology expands matures, it is important characterize elements that contribute success professionals this field. These individuals work a wide variety settings, including core facilities, biological medical research laboratories, software development organizations, pharmaceutical...
Phylogenetic analyses based on mitochondrial (mt) DNA have indicated that the cichlid species flock of Lake Victoria region is derived from a single ancestral found in East African rivers, closely related to ancestor Malawi flock. The contains ten times less mtDNA variation than radiation, consistent with current estimates ages lakes. We present results phylogenetic investigation using nuclear (amplified fragment length polymorphism) markers and wider coverage riverine haplochromines....
We have determined that repetitive (repetitive extragenic palindromic [REP] and enterobacterial intergenic consensus [ERIC]) sequences used in conjunction with the polymerase chain reaction technique (REP ERIC PCR) provide an effective means of differentiating between classifying genetically related Bradyrhizobium japonicum serocluster 123 strains. Analysis REP PCR-generated dendrograms indicated this can effectively differentiate closely strains which were indistinguishable by using other...
We have cloned and characterized three distinct Rhizobium meliloti loci involved in glutamine biosynthesis (glnA, glnII, glnT). The glnA locus shares DNA homology with the gene of Klebsiella pneumoniae, encodes a 55,000-dalton monomer subunit heat-stable synthetase (GS) protein (GSI), complemented an Escherichia coli mutation. glnII Bradyrhizobium japonicum 36,000-dalton heat-labile GS (GSII). glnT no either or E. strain. codes for operon encoding polypeptides 57,000, 48,000, 35,000, 29,000,...
The mountains of data thrusting from the new landscape modern high-throughput biology are irrevocably changing biomedical research and creating a near-insatiable demand for training in management manipulation mining analysis. Among life scientists, clinicians to environmental researchers, common theme is need not just use, gain familiarity with, bioinformatics tools resources but also understand their underlying fundamental theoretical practical concepts. Providing empower scientists handle...
In recent years, high-throughput technologies have brought big data to the life sciences. The march of progress has been rapid, leaving in its wake a demand for courses analysis, stewardship, computing fundamentals, etc., need that universities not yet able satisfy—paradoxically, many are actually closing "niche" bioinformatics at time critical need. impact this is being felt across continents, as students and early-stage researchers left without appropriate skills manage, analyse, interpret...
ABSTRACT Four hundred thirty-three xanthomonad strains isolated from tomato or pepper plants 32 different fields in four Caribbean and Central American countries were screened for the ability to hydrolyze starch sodium polypectate resistance copper streptomycin. Of these, 95 representative further characterized by various phnetic tests, 63 of these then analyzed genomic fingerprinting. Most (>90%) tolerant copper. However, there was much more variability sensitivity All Guadeloupe 93%...
Haplochromine cichlid fish have radiated into hundreds of species in East-African lakes, possibly driven by divergent sexual selection on body coloration. We studied the color polymorphic Lake Victoria Neochromis omnicaeruleus, which a presumably ancestral phenotype with blue males and brown females co-occurs two distinct classes blotched phenotypes both sexes. Similar blotch polymorphisms occur other haplochromine species, all cases are much more common than males. In N. near absence seems...
Abstract Theory predicts that asexual reproduction has a competitive advantage over sexual because of the twofold cost producing males. Few systems are suitable for directly testing this prediction. In solitary parasitoid wasp Venturia canescens both arrhenotokously (sexual) and thelytokously (asexual) reproducing individuals occur sympatrically. We sampled 922 wasps from 22 localities along coast south-eastern France. Thelytokous were less abundant (23%) than arrhenotokous almost always...
Divergent selection acting on several different traits that cause multidimensional shifts are supposed to promote speciation, but the outcome of this process is highly dependent balance between strength vs. gene flow. Here, we studied a pair sister species Lake Victoria cichlids at location where they hybridize and tested hypothesis divergent can maintain phenotypic differentiation despite To explore possible role for correlations phenotypes environment compared divergence (P(ST)) with based...
Abstract Summary: Rapid technological advances have led to an explosion of biomedical data in recent years. The pace change has inspired new collaborative approaches for sharing materials and resources help train life scientists both the use cutting-edge bioinformatics tools databases how analyse interpret large datasets. A prototype platform such training was recently created by Bioinformatics Training Network (BTN). Building on this work, we a centralized portal courses, including...
<ns4:p>Throughout history, the life sciences have been revolutionised by technological advances; in our era this is manifested advances instrumentation for data generation, and consequently researchers now routinely handle large amounts of heterogeneous digital formats. The simultaneous transitions towards biology as a science ‘life cycle’ view research pose new challenges. Researchers face bewildering landscape management requirements, recommendations regulations, without necessarily being...
This article aims to introduce the nature of data integration life scientists. Generally, subject is not discussed outside field computational science and covered in any detail, or even neglected, when teaching/training trainees. End users (hereby defined as wet-lab trainees, clinicians, lab researchers) will mostly interact with bioinformatics resources tools through web interfaces that mask user from processes. However, lack formal training acquaintance simple database concepts terminology...