A5064435463- Gene expression and cancer classification
- Genetics, Bioinformatics, and Biomedical Research
- Biomedical Text Mining and Ontologies
- Developmental Biology and Gene Regulation
- Simulation Techniques and Applications
- Research Data Management Practices
- Molecular Biology Techniques and Applications
- Genomics and Phylogenetic Studies
- Scientific Computing and Data Management
- Congenital heart defects research
- Single-cell and spatial transcriptomics
- Visual perception and processing mechanisms
- Cell Image Analysis Techniques
- Cancer-related gene regulation
- Animal Genetics and Reproduction
- Wnt/β-catenin signaling in development and cancer
- Advanced Computational Techniques and Applications
- Color perception and design
- Business Process Modeling and Analysis
- Genetic diversity and population structure
- Bioinformatics and Genomic Networks
- Modeling, Simulation, and Optimization
- Environmental DNA in Biodiversity Studies
- Color Science and Applications
- Hedgehog Signaling Pathway Studies
Monash University
2013-2024
The University of Queensland
1994-2023
The University of Melbourne
2023
Atlas of Living Australia
2023
Commonwealth Scientific and Industrial Research Organisation
2023
Queensland Museum
2023
Biocom
2022
Essen University Hospital
2021
Queensland Cyber Infrastructure Foundation
2021
Australia Bioinformatics Resource
2021
Wnt genes have been implicated in a range of developmental processes the mouse including patterning central nervous system and limbs. Reported here for first time is expression Wnt2 early heart field 7.5-8.5 dpc (days post-coitum) embryos, making potentially useful gene marker stages development. Expression was also detected allantois from 8.0 at later placenta umbilicus. Mice deficient Wnt2, generated by targeting, displayed runting approximately 50% died perinatally. Histological analysis...
Drosophila patched is a segment polarity gene required for the correct patterning of larval segments and imaginal discs during fly development has close functional relationship with hedgehog. We have isolated complete human PATCHED cDNA sequence, which encodes putative protein 1296 amino acids, displays 39% identity 60% similarity to protein. Hydropathy analysis suggests that an integral membrane pattern hydrophobic hydrophilic stretches nearly identical patched. In developing mouse embryo,...
EMAGE (http://www.emouseatlas.org/emage) is a freely available online database of in situ gene expression patterns the developing mouse embryo. Gene domains from raw images are extracted and integrated spatially into set standard 3D virtual embryos at different stages development, which allows data interrogation by spatial methods. An anatomy ontology also used to describe sites expression, be queried using text-based Here, we recent enhancements including: release completely re-designed...
EMAGE (http://genex.hgu.mrc.ac.uk/Emage/database) is a freely available, curated database of gene expression patterns generated by in situ techniques the developing mouse embryo. It unique that it contains standardized spatial representations sites for each gene, denoted against set virtual reference embryo models. As such, data can be interrogated novel and abstract manner using space to define query. Accompanying are text descriptions expression, which also allows searching more...
Here agent‐based models are employed to explore the behavior of small communities and their associated economic systems within an area climatically marginal environment in northern Syria Iraq. The examples, drawn from late prehistoric Bronze Age societies that developed at onset urbanization, show how might respond various resource stresses environmental fluctuations. computer simulations demonstrate some households gain resources expense others community becomes more economically...
<ns4:p>Throughout history, the life sciences have been revolutionised by technological advances; in our era this is manifested advances instrumentation for data generation, and consequently researchers now routinely handle large amounts of heterogeneous digital formats. The simultaneous transitions towards biology as a science ‘life cycle’ view research pose new challenges. Researchers face bewildering landscape management requirements, recommendations regulations, without necessarily being...
Previous work has revealed that proteins bind to bone morphogenetic (BMPs) and inhibit their signalling have a crucial role in the spatial temporal regulation of cell differentiation migration by BMPs. We identified chick homologue crossveinless 2, Drosophila gene was genetic studies as promoter BMP-like signalling. Chick Cv-2 conserved structure five cysteine-rich repeats similar those found several BMP antagonists, C-terminal Von Willebrand type D domain. is expressed embryo number tissues...
In 2010, the Human Proteome Organization launched Project (HPP), aimed at identifying and characterizing proteome of human body. To support complete coverage, one arm project will take a gene- or chromosomal-centric strategy (C-HPP) least protein product from each protein-coding gene. Despite multiple large international biological databases housing genomic data, there is currently no single system that integrates updated pertinent information these data repositories assembles into...
Throughout history, the life sciences have been revolutionised by technological advances; in our era this is manifested advances instrumentation for data generation, and consequently researchers now routinely handle large amounts of heterogeneous digital formats. The simultaneous transitions towards biology as a science 'life cycle' view research pose new challenges. Researchers face bewildering landscape management requirements, recommendations regulations, without necessarily being able to...
EMAGE (http://genex.hgu.mrc.ac.uk/Emage/database) is a database of in situ gene expression patterns the developing mouse embryo. Domains from raw data images are spatially integrated into set standard 3D virtual embryos at different stages development, allowing interrogation by spatial methods. Sites also described using an anatomy ontology and can be queried text-based Here we describe recent enhancements to which include advances search methods including: refined local similarity...
In 2011, Watson and Barnes proposed a schema for classifying biobanks into 3 groups (mono-, oligo-, poly-user), primarily based upon biospecimen access policies. We used results from recent comprehensive survey of cancer in New South Wales, Australia to assess the applicability this biobank classification an Australian setting. Cancer were identified using publicly available data, by consulting with research managers. A was developed administered through face-to-face Data analyzed Microsoft...
The Eph family of receptor tyrosine kinases and their ligands, the ephrins, act as signaling molecules regulating migratory behavior neurons neural crest cells, are implicated in tissue patterning, blood vessel formation, tumorigenesis. On basis structural similarities overlapping binding specificities, receptors well ligands can be divided into A B subfamilies with orthologues found all vertebrates. We describe here isolation cDNAs encoding Xenopus EphB4 show that embryonic expression is...
Objective— To report a serious complication in dog with masticatory muscle myositis (MMM) that occurred during general anesthesia for diagnostic testing. Study Design— Case report. Animals— A 2‐year‐old male Pug. Methods— MMM was diagnosed Pug 2‐week history of trismus by electrodiagnostics, histopathology, and 2M antibody test. During tongue protrusion because trismus, an inability to reposition the resulted venous congestion severe swelling. Forceful physical attempts subsequent removal...