Jason Turner-Maier
A5000623764- Virus-based gene therapy research
- Veterinary Oncology Research
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Genomics and Phylogenetic Studies
- Vascular Tumors and Angiosarcomas
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Tumors and Oncological Cases
- Infectious Diseases and Mycology
- Bat Biology and Ecology Studies
- Wildlife Ecology and Conservation
- Marine animal studies overview
- Fish Biology and Ecology Studies
- High Altitude and Hypoxia
- Evolution and Paleontology Studies
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Hedgehog Signaling Pathway Studies
- Animal Genetics and Reproduction
Broad Institute
2011-2023
Howard Hughes Medical Institute
2023
University of California, Santa Cruz
2023
University of California, Riverside
2023
Morningside College
2023
University of Massachusetts Chan Medical School
2023
Science for Life Laboratory
2023
Uppsala University
2023
Cleveland Museum of Natural History
2023
Massachusetts Institute of Technology
2014-2022
Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. To understand molecular mechanisms underlying cichlid phenotypic diversity, we sequenced genomes transcriptomes five lineages African cichlids: Nile tilapia (Oreochromis niloticus), an ancestral lineage with low diversity; four members lineage: Neolamprologus brichardi/pulcher (older radiation, Lake Tanganyika), Metriaclima zebra (recent Malawi), Pundamilia nyererei (very recent...
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage lobe-finned fish thought to have become extinct 70 million years ago. modern looks remarkably similar many its ancient relatives, and evolutionary proximity our own ancestors provides glimpse the that first walked on land. Here we report genome sequence African coelacanth, Latimeria chalumnae. Through phylogenomic analysis, conclude lungfish, not is closest relative tetrapods. Coelacanth protein-coding...
The evolution of the amniotic egg was one great evolutionary innovations in history life, freeing vertebrates from an obligatory connection to water and thus permitting conquest terrestrial environments. Among amniotes, genome sequences are available for mammals birds, but not non-avian reptiles. Here we report sequence North American green anole lizard, Anolis carolinensis. We find that A. carolinensis microchromosomes highly syntenic with chicken microchromosomes, yet do exhibit high GC...
The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for rabbit and compared it to resequencing data from populations wild domestic rabbits. identified more than 100 selective sweeps specific rabbits but only relatively small number fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) derived alleles. SNPs with marked allele frequency differences between were enriched conserved noncoding...
The domestic dog, Canis familiaris, is a well-established model system for mapping trait and disease loci. While the original draft sequence was of good quality, gaps were abundant particularly in promoter regions genome, negatively impacting annotation study candidate genes. Here, we present an improved genome build, canFam3.1, which includes 85 MB novel now covers 99.8% euchromatic portion genome. We also multiple RNA-Sequencing data sets from 10 different canine tissues to catalog...
Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,385 purebred and mixed-breed genotyping 2155 dogs. Most traits heritable [heritability ( h 2 ) > 25%], admixture patterns reveal propensities. Breed explains just 9% variation individuals. Genome-wide association analyses identify 11 loci that significantly associated...
The genome sequence of the ferret, a model human respiratory disease, enables research on influenza and cystic fibrosis. domestic ferret (Mustela putorius furo) is an important animal for multiple diseases. It considered 'gold standard' modeling virus infection transmission1,2,3,4. Here we describe 2.41 Gb draft assembly constituting 2.28 plus gaps. We annotated 19,910 protein-coding genes this using RNA-seq data from 21 tissues. characterized host response to two infections by analysis 42...
Lymphoma is the most common hematological malignancy in developed countries. Outcome strongly determined by molecular subtype, reflecting a need for new and improved treatment options. Dogs spontaneously develop lymphoma, predisposition of certain breeds indicates genetic risk factors. Using dog breed structure, we selected three lymphoma predisposed developing primarily T-cell (boxer), B-cell (cocker spaniel), with equal distribution B- (golden retriever), respectively. We investigated...
Abstract Angiosarcoma is a highly aggressive cancer of blood vessel–forming cells with few effective treatment options and high patient mortality. It both rare heterogenous, making large, well-powered genomic studies nearly impossible. Dogs commonly suffer from similar cancer, called hemangiosarcoma, breeds like the golden retriever carrying heritable genetic factors that put them at risk. If clinical similarity canine hemangiosarcoma human angiosarcoma reflects shared etiology, dogs could...
Abstract Osteosarcoma is a debilitating bone cancer that affects humans, especially children and adolescents. A homologous form of osteosarcoma spontaneously occurs in dogs, its differential incidence observed across breeds allows for the investigation tumor mutations context multiple genetic backgrounds. Using whole-exome sequencing dogs from three susceptible (22 golden retrievers, 21 Rottweilers, 23 greyhounds), we found tumors show high frequency somatic copy-number alterations (SCNA),...
Decrypting the rearrangements that drive mammalian chromosome evolution is critical to understanding molecular bases of speciation, adaptation, and disease susceptibility. Using 8 scaffolded 26 chromosome-scale genome assemblies representing 23/26 mammal orders, we computationally reconstructed ancestral karyotypes syntenic relationships at 16 nodes along phylogeny. Three different reference genomes (human, sloth, cattle) phylogenetically distinct superorders were used assess bias in expand...
Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma both malignancies the hematologic system that clinically histologically similar to non-Hodgkin angiosarcoma, respectively. Golden retrievers in US show significantly elevated lifetime risk for (6%) (20%). We conducted genome-wide association studies lymphoma, identifying two shared predisposing loci. The associated loci located on...
Dogs are an unparalleled natural model for investigating the genetics of health and disease, particularly complex diseases like cancer. Comprehensive genomic annotation regulatory elements active in healthy canine tissues is crucial both identifying candidate causal variants designing functional studies needed to translate genetic associations into disease insight. Currently, geneticists rely primarily on annotations human or mouse genome that have been remapped dog, approach misses...
Abstract Sporadic angiosarcomas are aggressive vascular sarcomas whose rarity and genomic complexity present significant obstacles in deciphering the pathogenic significance of individual genetic alterations. Numerous fusion genes have been identified across multiple types cancers, but their existence remain unclear sporadic angiosarcomas. In this study, we leveraged RNA-sequencing data from 13 human 76 spontaneous canine hemangiosarcomas to identify associated with malignancies. Ten novel...
Our purpose was to obtain genome-wide expression data for the rabbit species on responses of peripheral blood mononuclear cells (PBMCs) after in vitro stimulation by lipopolysaccharide (LPS) or phorbol myristate acetate (PMA) and ionomycin. This transcriptome profiling carried out using microarrays enriched with immunity-related genes, annotated most recent available genome. The LPS affected 15 20 times fewer genes than PMA-Ionomycin both 4 hours (T4) 24 (T24), stimulation, comparison...
Obtaining labeled data is a significant obstacle for many NLP tasks. Recently, online games have been proposed as new way of obtaining data; attract users by being fun to play. In this paper, we consider the application idea collecting semantic relations between words, such hypernym/hyponym relationships. We built three games, inspired real-life Scattergories™ and Taboo™. As June 2008, players entered nearly 800,000 instances, in two categories. The first type consists category/answer pairs...
Nitric oxide (NO) is a potent vasodilator, which improves perfusion and oxygen delivery during tissue hypoxia in terrestrial animals. The vertebrate dive response involves vasoconstriction select tissues, persists despite profound hypoxia. Using tissues collected from Weddell seals at necropsy, we investigated whether aided by downregulation of local signaling mechanisms. We focused on NO-soluble guanylyl cyclase (GC)-cGMP signaling, well-known vasodilatory transduction pathway. Seals have...
Abstract The Weddell seal ( Leptonychotes weddellii ) thrives in its extreme Antarctic environment. We generated the genome assembly and a high-quality annotation to investigate genome-wide evolutionary pressures that underlie phenotype study genes implicated hypoxia tolerance lipid-based metabolism. Genome-wide analyses included gene family expansion/contraction, positive selection, diverged sequence (acceleration) compared other placental mammals, identifying selection coding non-coding...
The characterization of immortalized canine osteosarcoma (OS) cell lines used for research has historically been based on phenotypic features such as cellular morphology and expression bone specific markers. With the increasing use these to investigate novel therapeutic approaches prior in vivo translation, a much more detailed understanding regarding genomic landscape is required ensure accurate interpretation findings. Here we report first whole genome eight OS lines, including single...
Abstract Angiosarcoma is a highly aggressive cancer of blood vessel-forming cells with high fatality and few effective treatment options. It both rare heterogenous, making large, well powered genomic studies nearly impossible. In dogs, angiosarcoma common, breeds like the golden retriever carrying heritable genetic factors that put them at very risk. If clinical similarity canine human reflects shared etiology, dogs could be critically needed model for advancing research. We assessed...
Abstract Sporadic angiosarcomas (ASs) are aggressive vascular sarcomas whose rarity and genomic complexity present significant obstacles in deciphering the pathogenic significance of individual genetic alterations. Numerous fusion genes have been identified across multiple types cancers, but their existence remain unclear sporadic ASs. In this study, we leveraged RNA sequencing data from thirteen human ASs 76 spontaneous canine hemangiosarcomas (HSAs) to identify associated with...