A5037579287- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- Prostate Cancer Treatment and Research
- Multiple Myeloma Research and Treatments
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- Protein Degradation and Inhibitors
- Glycosylation and Glycoproteins Research
- Lymphoma Diagnosis and Treatment
- Cancer-related gene regulation
Broad Institute
2014-2024
Dana-Farber Cancer Institute
2014-2024
Harvard University
2024
Massachusetts Institute of Technology
2024
Circulating tumor cells provide a practical and noninvasive way to monitor multiple myeloma.
Lymphoma is the most common hematological malignancy in developed countries. Outcome strongly determined by molecular subtype, reflecting a need for new and improved treatment options. Dogs spontaneously develop lymphoma, predisposition of certain breeds indicates genetic risk factors. Using dog breed structure, we selected three lymphoma predisposed developing primarily T-cell (boxer), B-cell (cocker spaniel), with equal distribution B- (golden retriever), respectively. We investigated...
LINE-1 (L1) retrotransposition is widespread in many cancers, especially those with a high burden of chromosomal rearrangements. However, whether and to what degree L1 activity directly impacts genome integrity unclear. Here, we apply whole-genome sequencing experimental models expression comprehensively define the spectrum genomic changes caused by L1. We provide definitive evidence that frequently causes both local long-range rearrangements, small large segmental copy-number alterations,...