A5054285510- Primate Behavior and Ecology
- Animal Behavior and Reproduction
- Human-Animal Interaction Studies
- Neuroendocrine regulation and behavior
- Diet and metabolism studies
- Evolutionary Psychology and Human Behavior
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Animal Vocal Communication and Behavior
- Epigenetics and DNA Methylation
- Wildlife Ecology and Conservation
- Genetics, Aging, and Longevity in Model Organisms
- Evolutionary Game Theory and Cooperation
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Regulation of Appetite and Obesity
- Zoonotic diseases and public health
- Dietary Effects on Health
- Birth, Development, and Health
- Bat Biology and Ecology Studies
- Single-cell and spatial transcriptomics
- Genetic and phenotypic traits in livestock
- Molecular Biology Techniques and Applications
- Alzheimer's disease research and treatments
Arizona State University
2018-2025
University of Washington
2018-2024
University of Pennsylvania
2009-2023
Tempe Union High School District
2022
Seattle University
2019-2021
Duke University
2013-2020
University of Konstanz
2016
University of Cape Town
2016
National Museums of Kenya
2016
Institute of Primate Research
2016
Status alters immune function in macaques Rhesus experience variable levels of stress on the basis their position social hierarchy. To examine how affects function, Snyder-Mackler et al. manipulated status individual (see Perspective by Sapolsky). Social influenced system at multiple levels, from cell numbers to gene expression, and altered signaling pathways a model response infection. Macaques possess plastic adaptive wherein subordination promotes antibacterial responses, whereas high...
Abstract Background Adaptive shifts in gut microbiome composition are one route by which animals adapt to seasonal changes food availability and diet. However, outside of dietary shifts, other potential environmental drivers microbial have rarely been investigated, particularly organisms living their natural environments. Results Here, we generated the largest wild nonhuman primate dataset date identify diversity function 758 samples collected from Ethiopian geladas ( Theropithecus gelada )....
Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,385 purebred and mixed-breed genotyping 2155 dogs. Most traits heritable [heritability ( h 2 ) > 25%], admixture patterns reveal propensities. Breed explains just 9% variation individuals. Genome-wide association analyses identify 11 loci that significantly associated...
Abstract Microglia, the innate immune cells of brain, influence Alzheimer’s disease (AD) progression and are potential therapeutic targets. However, microglia exhibit diverse functions, regulation which is not fully understood, complicating therapeutics development. To better define transcriptomic phenotypes gene regulatory networks associated with AD, we enriched for nuclei from 12 AD 10 control human dorsolateral prefrontal cortices (7 males 15 females, all aged >60 years) before...
Many species use social interactions to cope with challenges in their environment and a growing number of studies show that individuals which are well-connected group have higher fitness than socially isolated individuals. However, there many ways be ‘well-connected’ it is unclear aspects sociality drive benefits. Being can conceptualized four main ways: integrated by engaging high rate behaviour or having partners; they strong stable connections favoured indirectly connect the broader...
Variation across dog breeds presents a unique opportunity to investigate the evolution and biological basis of complex behavioural traits. We integrated data from more than 14 000 dogs 101 with breed-averaged genotypic ( n = 5697 dogs) over 100 loci in genome. found high levels among-breed heritability for traits (the proportion trait variance attributable genetic similarity among breeds). next identified 131 single nucleotide polymorphisms associated breed differences behaviour, which were...
Research on the genetics of natural populations was revolutionized in 1990s by methods for genotyping noninvasively collected samples. However, these have remained largely unchanged past 20 years and lag far behind genomics era. To close this gap, here we report an optimized laboratory protocol genome-wide capture endogenous DNA from samples, coupled with a novel computational approach to reconstruct pedigree links resulting low-coverage data. We validated both using fecal samples 62 wild...
Baboons, members of the genus Papio, comprise six closely related species distributed throughout sub-Saharan Africa and southwest Arabia. The exhibit more ecological flexibility a wider range social systems than many other primates. This article summarizes our current knowledge natural history baboons highlights directions for future research. We suggest that can serve as valuable model complex evolutionary processes, such speciation hybridization. evolution has been heavily shaped by...
Of all the non-human primate species studied by researchers, rhesus macaque (Macaca mulatta) is likely most widely used across biological disciplines. Rhesus macaques have thrived during Anthropocene and now largest natural range of any primate. They are highly social, exhibit marked genetic diversity, display remarkable niche flexibility (which allows them to live in a habitats survive on variety diets). These characteristics mean that well-suited for understanding links between sociality,...
Weather-related disasters are increasing in frequency and severity, leaving survivors to cope with ensuing mental, financial, physical hardships. This adversity can exacerbate existing morbidities, trigger new ones, increase the risk of mortality-features that also characteristic advanced age-inviting hypothesis extreme weather events may accelerate aging. To test this idea, we examined impact Hurricane Maria its aftermath on immune cell gene expression large, age-matched, cross-sectional...
Reproduction and survival in most primate species reflects management of both competitive cooperative relationships. Here, we investigated the links between neuroanatomy sociality free-ranging rhesus macaques. In adults, number social partners predicted volume mid–superior temporal sulcus ventral-dysgranular insula, implicated decision-making empathy, respectively. We found no link brain structure other key variables such as status or indirect connectedness nor maternal networks dependent...
Accumulating evidence in humans and other mammals suggests older individuals tend to have smaller social networks. Uncovering the cause of these declines can inform how changes relationships with age affect health fitness later life. While age-based networks been thought be detrimental, physical physiological limitations associated may lead adjust their behavior more selective partner choice. Greater selectivity has shown humans, but extent which this phenomenon occurs across animal kingdom...
Cataloging the diverse cellular architecture of primate brain is crucial for understanding cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas rhesus macaque brain. Together, profiled 2.58 M transcriptomes 1.59 epigenomes from single nuclei sampled 30 regions across adult Cell composition differed extensively brain, revealing signatures region-specific functions. We also identified 1.19 candidate regulatory elements, many...
Extreme weather events radically alter ecosystems. When ecological damage persists, selective pressures on individuals can change, leading to phenotypic adjustments. For group-living animals, social relationships may be a mechanism enabling adaptation ecosystem disturbance. Yet whether such selection sociality and animals can, as result, adaptively change their remain untested. We leveraged 10 years of data collected rhesus macaques before after category 4 hurricane caused persistent...
Abstract Across mammals, the epigenome is highly predictive of chronological age. These “epigenetic clocks,” most which have been built using DNA methylation (DNAm) profiles, gained traction as biomarkers aging and organismal health. While ability DNAm to predict age has repeatedly demonstrated, other epigenetic features remains unclear. Here, we use two types information—DNAm, chromatin accessibility measured by ATAC‐seq—to develop predictors in peripheral blood mononuclear cells sampled...
Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders and neurodegenerative diseases. Here, we generated one largest multi-brain-region bulk transcriptional datasets for rhesus macaque characterized sex-biased gene expression patterns to investigate translatability this species neurological conditions. We identify similar those humans, which are associated with overlapping regulatory mechanisms, biological processes, genes implicated human disorders, including...
By living in social groups with potential competitors, animals forgo monopolizing access to resources. Consequently, debate continues over how selection might favour sociality among competitors. For example, several models exist account for the evolution of shared reproduction groups. The 'concession model' hypothesizes that dominant reproducers benefit from presence subordinates, and hence tolerate some by subordinates. This mutual both dominants subordinates may provide a foundation...
Low social status is an important predictor of disease susceptibility and mortality risk in humans other mammals. These effects are thought to stem part from dysregulation the glucocorticoid (GC)-mediated stress response. However, molecular mechanisms that connect low GC downstream health outcomes remain elusive. Here, we used vitro challenge investigate consequences experimentally manipulated (i.e., dominance rank) for immune cell gene regulation female rhesus macaques, using paired control...
Naturally occurring admixture has now been documented in every major primate lineage, suggesting its key role evolutionary history. Active hybrid zones can provide valuable insight into this process. Here, we investigate the history of one best-studied natural zones, between yellow baboons (Papio cynocephalus) and anubis anubis) Amboseli ecosystem Kenya. We generated a new genome assembly for baboon low-coverage genomewide resequencing data from baboons, known hybrids (n = 44). Using novel...