A5011892628- Animal Behavior and Reproduction
- Reproductive biology and impacts on aquatic species
- Animal Behavior and Welfare Studies
- Genetic and phenotypic traits in livestock
- Human-Animal Interaction Studies
- Genomics and Phylogenetic Studies
- Neuroendocrine regulation and behavior
- Fish Ecology and Management Studies
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
University of Massachusetts Chan Medical School
2019-2022
Broad Institute
2021-2022
University of New England
2014
Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,385 purebred and mixed-breed genotyping 2155 dogs. Most traits heritable [heritability ( h 2 ) > 25%], admixture patterns reveal propensities. Breed explains just 9% variation individuals. Genome-wide association analyses identify 11 loci that significantly associated...
Dogs are an unparalleled natural model for investigating the genetics of health and disease, particularly complex diseases like cancer. Comprehensive genomic annotation regulatory elements active in healthy canine tissues is crucial both identifying candidate causal variants designing functional studies needed to translate genetic associations into disease insight. Currently, geneticists rely primarily on annotations human or mouse genome that have been remapped dog, approach misses...
Both acute and chronic exposure to 17α-ethinylestradiol (EE2), one of the primary active ingredients birth control pills, decreases courtship aggression in males aquatic species. However, how affects behavioral consistency over time is not commonly addressed. To examine effects EE2 on consistency, adult male Siamese fighting fish, Betta splendens , received multiple trials with a dummy female presented simultaneously both before after nominal dose (10 ng/l) EE2. The responses exposed were...