A5063932997- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Primate Behavior and Ecology
- Fetal and Pediatric Neurological Disorders
- Ultrasound Imaging and Elastography
- Neuroendocrine regulation and behavior
- Action Observation and Synchronization
- Face Recognition and Perception
- Visual perception and processing mechanisms
- Hemispheric Asymmetry in Neuroscience
- Evolution and Paleontology Studies
- MRI in cancer diagnosis
- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
- Comparative Animal Anatomy Studies
- Photoreceptor and optogenetics research
- Mental Health Research Topics
- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
Wellcome Centre for Integrative Neuroimaging
2014-2025
Institut Cellule Souche et Cerveau
2007-2025
Inserm
2007-2025
Université Claude Bernard Lyon 1
2012-2025
University of Oxford
2015-2024
John Radcliffe Hospital
2012-2024
Wellcome Trust
2018-2024
Stanford University
2010
Institut des Sciences Cognitives
2004
Centre National de la Recherche Scientifique
2004
Retrograde tracer injections in 29 of the 91 areas macaque cerebral cortex revealed 1,615 interareal pathways, a third which have not previously been reported. A weight index (extrinsic fraction labeled neurons [FLNe]) was determined for each area-to-area pathway. Newly found projections were weaker on average compared with known projections; nevertheless, 2 sets pathways had extensively overlapping distributions. Repeat across individuals modest FLNe variability given range values (standard...
The default mode network (DMN) of the brain consists areas that are typically more active during rest than task performance. Recently however, this has been shown to be activated by certain types tasks. Social cognition, particularly higher-order tasks such as attributing mental states others, suggested activate a at least partly overlapping with DMN. Here, we explore claim, drawing on evidence from meta-analyses functional MRI data and recent studies investigating structural connectivity...
Facing the consequence of a decision we made can trigger emotions like satisfaction, relief, or regret, which reflect our assessment what was gained as compared to would have been by making different decision. These are mediated cognitive process known counterfactual thinking. By manipulating simple gambling task, characterized subject's choices in terms their anticipated and actual emotional impact. Normal subjects reported responses consistent with thinking; they chose minimize future...
Controversy surrounds the role of temporoparietal junction (TPJ) area human brain. Although TPJ has been implicated both in reorienting attention and social cognition, it is still unclear whether these functions have same neural basis. Indeed, a precisely identifiable cortical region or cluster subregions with separate matter debate. Here, we examined structural functional connectivity TPJ, testing unitary heterogeneous profile conglomerate regions distinctive connectivity....
It has been suggested that variation in brain structure correlates with the sizes of individuals' social networks. Whether network size causes structure, however, is unknown. To address this question, we neuroimaged 23 monkeys had living groups set to different sizes. Subject comparison revealed larger caused increases gray matter mid-superior temporal sulcus and rostral prefrontal cortex increased coupling activity frontal cortex. Social size, therefore, contributes changes both function....
Despite the prominence of parietal activity in human neuroimaging investigations sensorimotor and cognitive processes, there remains uncertainty about basic aspects cortical anatomical organization. Descriptions cortex draw heavily on schemes developed other primate species, but validity such comparisons has been questioned by claims that are fundamental differences between humans primates. A scheme is presented for parcellation lateral into component regions basis connectivity functional...
The human dorsal frontal cortex has been associated with the most sophisticated aspects of cognition, including those that are thought to be especially refined in humans. Here we used diffusion-weighted magnetic resonance imaging (DW-MRI) and functional MRI (fMRI) humans macaques infer compare organization two species. Using DW-MRI tractography-based parcellation, identified 10 regions lying between inferior sulcus cingulate cortex. Patterns coupling each area rest brain were then estimated...
Significance Because of the interest in reward-guided learning and decision making, these neural mechanisms have been studied both humans monkeys. But whether how key brain areas correspond between two species has uncertain. Areas can be compared as a function circuits which they participate, estimated from patterns correlation activity measured with functional MRI. Taking such measurements 38 25 macaques, we identified fundamental similarities one human frontal area no monkey counterpart....
Uncertainty about the function of orbitofrontal cortex (OFC) in guiding decision-making may be a result its medial (mOFC) and lateral (lOFC) divisions having distinct functions. Here we test hypothesis that mOFC is more concerned with reward-guided decision making, contrast lOFC's role learning. Macaques performed three-armed bandit tasks effects selective lesions were contrasted against lOFC lesions. First, present analyses make it possible to measure reward-credit assignment—a crucial...
The causal role of an area within a neural network can be determined by interfering with its activity and measuring the impact. Many current reversible manipulation techniques have limitations preventing their application, particularly in deep areas primate brain. Here, we demonstrate that focused transcranial ultrasound stimulation (TUS) protocol impacts even brain areas: subcortical structure, amygdala (experiment 1), cortical region, anterior cingulate cortex (ACC, experiment 2),...
To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound stimulation (TUS) a promising non-invasive technique. date, investigations report short-lived neuromodulatory effects, but deliver on its full potential for research therapy, protocols are required that induce longer-lasting ‘offline’ changes. Here, we present TUS protocol modulates activation in macaques more than one hour after 40 s of stimulation, while circumventing auditory...
Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational cross-species comparative neuroscience. Unfortunately, the technological methodological advances past two decades have outpaced accrual data, which particularly challenging given relatively few centers necessary facilities capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human magnetic resonance imaging...
We present a new software package with library of standardised tractography protocols devised for the robust automated extraction white matter tracts both in human and macaque brain. Using vivo data from Human Connectome Project (HCP) UK Biobank ex brain datasets, we obtain atlases, as well atlases tract endpoints on white-grey boundary, species. illustrate that our are against quality, generalisable across two species reflect known anatomy. further demonstrate they capture inter-subject...
In the absence of external stimuli or task demands, correlations in spontaneous brain activity (functional connectivity) reflect patterns anatomical connectivity. Hence, resting-state functional connectivity has been used as a proxy measure for structural and biomarker changes disease. To relate to physiological brain, it is important understand how depend on physical integrity tissue. The causal nature this relationship called into question by patient data suggesting that decreased does not...
Comparing the brains of related species faces challenges establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between primates. The approach uses white matter blueprints whole cortex based on set tracts that can be anatomically matched across species. provide common reference space allows us to navigate different species, identify homologous cortical areas, or transform maps from one...
A neural circuit that covaries with social hierarchy neuroimaging study reveals individual variation in brain circuits structures below the cerebral cortex of macaques is associated experience at different ends hierarchy.
The human ability to infer the thoughts and beliefs of others, often referred as “theory mind,” well predisposition even consider are associated with activity in temporoparietal junction (TPJ) area. Unlike case most brain areas, we have little sense whether or how TPJ is related areas other nonhuman primates. It not possible address this question by looking for similar task-related activations primates because there no evidence that engage theory-of-mind tasks same manner humans. Here,...