A5043346981- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Attention Deficit Hyperactivity Disorder
- Cognitive Science and Mapping
- Visual perception and processing mechanisms
- Advanced Neuroimaging Techniques and Applications
- Advanced Memory and Neural Computing
- Mental Health Research Topics
- Neural Networks and Reservoir Computing
- Problem Solving Skills Development
- Education and Critical Thinking Development
- Heat and Mass Transfer in Porous Media
- Emotional Intelligence and Performance
- Nuclear Receptors and Signaling
- Advanced Fluorescence Microscopy Techniques
- Chemical and Environmental Engineering Research
- Real-Time Systems Scheduling
- Software System Performance and Reliability
- Phase Equilibria and Thermodynamics
- Pluripotent Stem Cells Research
University of Valparaíso
2011-2021
Viña del Mar University
2021
Inserm
2007-2016
Université Claude Bernard Lyon 1
2007-2016
Institut Cellule Souche et Cerveau
2007-2016
Retrograde tracer injections in 29 of the 91 areas macaque cerebral cortex revealed 1,615 interareal pathways, a third which have not previously been reported. A weight index (extrinsic fraction labeled neurons [FLNe]) was determined for each area-to-area pathway. Newly found projections were weaker on average compared with known projections; nevertheless, 2 sets pathways had extensively overlapping distributions. Repeat across individuals modest FLNe variability given range values (standard...
ABSTRACT The laminar location of the cell bodies and terminals interareal connections determines hierarchical structural organization cortex has been intensively studied. However, we still have only a rudimentary understanding connectional principles feedforward (FF) feedback (FB) pathways. Quantitative analysis retrograde tracers was used to extend notion that distribution neurons interconnecting visual areas provides an index distance (percentage supragranular labeled [SLN]). We show that:...
To what extent cortical pathways show significant weight differences and whether these are consistent across animals (thereby comprising robust connectivity profiles) is an important unresolved neuroanatomical issue. Here we report a quantitative retrograde tracer analysis in the cynomolgus macaque monkey of consistency afferents areas brains via calculation index (fraction labeled neurons, FLN). Injection 8 (3 occipital plus 5 other lobes) revealed pattern: small subcortical input (1.3%...
Primates display a remarkable ability to adapt novel situations. Determining what is most pertinent in these situations not always possible based only on the current sensory inputs, and often also depends recent inputs behavioral outputs that contribute internal states. Thus, one can ask how cortical dynamics generate representations of complex It has been observed mixed selectivity neurons contributes represent diverse defined by combination stimuli, readily obtained randomly connected...
To explain the high level of flexibility in primate decision-making, theoretical models often invoke reinforcement-based mechanisms, performance monitoring functions, and core neural features within frontal cortical regions. However, underlying biological mechanisms remain unknown. In recent models, part regulation behavioral control is based on meta-learning principles, for example, driving exploratory actions by varying a meta-parameter, inverse temperature, which regulates contrast...
The anterior cingulate cortex (ACC) and the lateral prefrontal (LPFC) process complementary information for planning evaluating behavior. This suggests at least that processes in these two areas are coordinated during behavioral adaptation. We analyzed local field potentials recorded both regions monkeys performing a problem-solving task alternated exploration repetitive behaviors with specific prediction neural activity should reveal interareal coordination mainly exploration. Both showed...
The frontal cortex controls behavioral adaptation in environments governed by complex rules. Many studies have established the relevance of firing rate modulation after informative events signaling whether and how to update policy. However, spatiotemporal features these neuronal activities contribute encoding imminent updates remains unclear. We investigated this issue dorsal anterior cingulate (dACC) monkeys while they adapted their behavior based on memory feedback from past choices....
While monkeys perform a task alternating between behavioral adaptation --relying on feedback monitoring and memory of previous choices-- repetition actions, firing rates in dorsal Anterior Cingulate Cortex (dACC) modulate with cognitive control levels [1]. Further, it has been hypothesized that dorsolateral Prefrontal (dlPFC) could make use dACC signals to take the adapted decision [2]. However, little is known about whether spike timing may participate signaling, how multiple unit...
Abstract Electrophysiological markers of performance monitoring are thought to reflect functioning dedicated neural networks and neuromodulatory systems. Whether how these altered in neurological diseases whether they can particular cognitive deficits remains be confirmed. Here we first tested the frontal medial feedback-related potential, evoked during a trial error learning task, is changed early Parkinson’s disease patients compared control subjects. The potential was not amplitude...
OBJECTIVE:To examine the prevalence, clinical correlates and cognitive impairments of apathy depression in a population sample patients with Parkinson's disease (PD)patients to analyze feedback-related signal modulations apathetic/non-apathetic depressive/non-depressive groups during problem solving task. BACKGROUND:PD is accompanied by variety neuropsychiatric symptoms deficits. One these apathy, which refers deficit such as blunted emotions, loss interest, lack productivity. The negativity...