A5030325071- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Face Recognition and Perception
- Primate Behavior and Ecology
- Evolution and Paleontology Studies
- Ultrasound and Hyperthermia Applications
- Comparative Animal Anatomy Studies
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Neuroendocrine regulation and behavior
- Transcranial Magnetic Stimulation Studies
- Bat Biology and Ecology Studies
- Photoacoustic and Ultrasonic Imaging
- Hemispheric Asymmetry in Neuroscience
- Fetal and Pediatric Neurological Disorders
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Photoreceptor and optogenetics research
- Cultural Differences and Values
- Child and Animal Learning Development
- Vestibular and auditory disorders
- Signaling Pathways in Disease
- Wildlife Ecology and Conservation
Wellcome Centre for Integrative Neuroimaging
2018-2024
University of Oxford
2018-2024
John Radcliffe Hospital
2018-2024
Université de Strasbourg
2018
Institut des Neurosciences Cellulaires et Intégratives
2018
To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound stimulation (TUS) a promising non-invasive technique. date, investigations report short-lived neuromodulatory effects, but deliver on its full potential for research therapy, protocols are required that induce longer-lasting ‘offline’ changes. Here, we present TUS protocol modulates activation in macaques more than one hour after 40 s of stimulation, while circumventing auditory...
The temporal association cortex is considered a primate specialization and involved in complex behaviors, with some, such as language, particularly characteristic of humans. emergence these behaviors has been linked to major differences lobe white matter humans compared monkeys. It unknown, however, how the organization differs across several anthropoid primates. Therefore, we systematically tracts human, gorilla, chimpanzee great apes macaque monkey. We show that apes, particular...
Post-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets investigate neuroanatomy and validate origins of image contrast through microscopy comparisons. We introduce Digital Brain Bank ( open.win.ox.ac.uk/DigitalBrainBank ), a data release platform providing open access curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes —Digital Neuroanatomist : for detailed neuroanatomical investigations; Zoo comparative...
Credit assignment is the association of specific instances reward to events, such as a particular choice, that caused them. Without credit assignment, choice values reflect an approximate estimate how good environment was when made—the global state—rather than exactly which outcome caused. Combined transcranial ultrasound stimulation (TUS) and functional magnetic resonance imaging in macaques demonstrate assignment–related activity prefrontal area 47/12o, this signal disrupted with TUS,...
Abstract Brains come in many shapes and sizes. Nature has endowed big-brained primate species like humans with a proportionally large cerebral cortex. Comparative studies have suggested, however, that the total volume allocated to white matter connectivity—the brain’s infrastructure for long-range interregional communication—does not keep pace We investigated consequences of this allometric scaling on brain connectivity network organization. collated structural diffusion magnetic resonance...
Significance Lateralization of functions in the brain has been demonstrated many different cognitive processes. It is supposed to increase processing abilities by reducing bilateral redundancy. Yet lateralization reward processing, despite extremely common asymmetrical findings, received little attention. Our neuroimaging study shows a functional response lateral part orbitofrontal cortex (OFC), together with an asymmetric connectivity pattern. This particular feature was identified not only...
Large-scale comparative neuroscience requires data from many species and, ideally, at multiple levels of description. Here, we contribute to this endeavor by presenting diffusion and structural MRI eight primate that have not or rarely been described in the literature. The selected samples Primate Brain Bank cover a prosimian, New Old World monkeys, great ape. We present preliminary labelling cortical sulci tractography optic radiation, dorsal part cingulum bundle, parietal-frontal ventral...
One of the most influential accounts central orbitofrontal cortex—that it mediates behavioral flexibility—has been challenged by finding that discrimination reversal in macaques, classic test flexibility, is unaffected when lesions are made excitotoxin injection rather than aspiration. This suggests critical brain circuit mediating flexibility tasks lies beyond cortex. To determine its identity, a group nine macaques were taught learning tasks, and impact on gray matter was measured....
When choosing, primates are guided not only by personal experience of objects but also social information such as others' attitudes toward the objects. Crucially, both sources information—personal and socially derived—vary in reliability. To choose optimally, one must sometimes override choice guidance follow cues instead, do opposite. The dorsomedial frontopolar cortex (dmFPC) tracks reliability determines whether it will be attended to guide behavior. this, dmFPC activity enters specific...
Comparative neuroimaging has been used to identify changes in white matter architecture across primate species phylogenetically close humans, but few have compared the distant species. Here, we acquired postmortem diffusion imaging data from ring-tailed lemurs (Lemur catta), black-capped squirrel monkeys (Saimiri boliviensis), and rhesus macaques (Macaca mulatta). We were able establish templates surfaces allowing us investigate sulcal, cortical, anatomy. The results demonstrate an expansion...
Abstract The ability to attribute thoughts others, also called theory of mind (TOM), has been extensively studied. Computationally, the basis TOM in humans interpreted within predictive coding framework and associated with activity temporo-parietal junction (TPJ). However, evolutionary origins these human mindreading abilities have challenged since concept was coined. Here we identify a brain region Rhesus macaque that shares computational properties TPJ. We revealed, using non-linguistic...
Abstract To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound (TUS) a promising non-invasive stimulation technique. date, investigations have focused on short-lived neuromodulatory effects, but deliver its full potential for research therapy, protocols are required that induce longer-lasting ‘offline’ changes. Here, we present TUS protocol modulates activation in macaques more than one hour after 40 seconds of stimulation, while...
Carnivorans are an important study object for comparative neuroscience, as they exhibit a wide range of behaviours, ecological adaptations, and social structures. Previous studies have mainly examined relative brain size, but comprehensive understanding diversity requires the investigation other aspects their neuroanatomy. Here, we obtained primarily post-mortem scans from eighteen species order Carnivora, reconstructed cortical surfaces, neocortical sulcal anatomy to establish framework...
The BigMac dataset is an open access resource combining in vivo MRI, postmortem MRI and multi-contrast microscopy data a single, whole macaque brain. Here we perform data-driven segmentation of the histology slides to extract quantitative metrics for myelin, cell density, cellular morphology (e.g. soma size packing). Utilising high-quality MRI-microscopy registrations, work towards building 3D volumes derived obtained at high resolution. This “ground truth” atlas how distributions vary...
ABSTRACT The interaction of the limbic system and frontal cortex primate brain is important in many affective behaviors. For this reason, it heavily implicated a number psychiatric conditions. This often studied macaque monkey, most largely-used non-human model species. However, how evolutionary conserved well results obtained any species translate to human can only be understood by studying its organization across order. Here, we present an investigation topology limbic-frontal connections...
Carnivorans are an important study object for comparative neuroscience, as they exhibit a wide range of behaviours, ecological adaptations, and social structures. Previous studies have mainly examined relative brain size, but comprehensive understanding diversity requires the investigation other aspects their neuroanatomy. Here, we obtained primarily post-mortem scans from eighteen species order Carnivora, reconstructed cortical surfaces, neocortical sulcal anatomy to establish framework...
Carnivorans are an important study object for comparative neuroscience, as they exhibit a wide range of behaviours, ecological adaptations, and social structures. Previous studies have mainly examined relative brain size, but comprehensive understanding diversity requires the investigation other aspects their neuroanatomy. Here, we obtained primarily post-mortem scans from eighteen species order Carnivora, reconstructed cortical surfaces, neocortical sulcal anatomy to establish framework...
Abstract Post-mortem MRI provides the opportunity to acquire high-resolution datasets investigate neuroanatomy, and validate origins of image contrast through microscopy comparisons. We introduce Digital Brain Bank ( open.win.ox.ac.uk/DigitalBrainBank ), a data release platform providing open access curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes - Neuroanatomist : for detailed neuroanatomical investigations; Zoo comparative neuroanatomy; Pathologist...
Abstract The orbitofrontal cortex (OFC) is a key brain region involved in complex cognitive functions such as reward processing and decision-making. Neuroimaging studies have shown unilateral OFC response to reward-related variables, however, those rarely discussed the lateralization of this effect. Yet, some lesion suggest that left right contribute differently processes. We hypothesized asymmetrical could reflect underlying hemispherical difference functional connectivity. Using...
Abstract One of the most influential accounts central orbitofrontal cortex– that it mediates behavioral flexibility – has been challenged by finding discrimination reversal in macaques –the classic test –is unaffected when lesions are made excitotoxin injection rather than aspiration. This suggests critical brain circuit mediating tasks lies beyond cortex. To determine its identity a group nine were taught learning and impact on grey matter was measured. Magnetic resonance imaging scans...
Abstract Brains come in many shapes and sizes. Nature has endowed big-brained primate species like humans with a proportionally large cerebral cortex. White matter connectivity – the brain’s infrastructure for long-range communication might not always scale at same pace as We investigated consequences of this allometric scaling white brain network connectivity. Structural T1 diffusion MRI data were collated across fourteen species, describing comprehensive 350-fold range volume. report...