A5074039331- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Action Observation and Synchronization
- EEG and Brain-Computer Interfaces
- Fetal and Pediatric Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Primate Behavior and Ecology
- Child and Animal Learning Development
- Visual perception and processing mechanisms
- Face Recognition and Perception
- Motor Control and Adaptation
- Psychological and Educational Research Studies
- Evolution and Paleontology Studies
- Neurobiology of Language and Bilingualism
- Neuroscience and Music Perception
- Neuroscience and Neuropharmacology Research
- MRI in cancer diagnosis
- Mental Health Research Topics
- Neuroendocrine regulation and behavior
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
University of Oxford
2016-2025
Radboud University Nijmegen
2016-2025
Wellcome Centre for Integrative Neuroimaging
2016-2025
John Radcliffe Hospital
2016-2025
Wellcome Trust
2020-2024
National Institute of Mental Health
2024
University of Toronto
2024
Allen Institute for Brain Science
2024
National Health Research Institutes
2020
National Institutes of Health
2020
When asked to perform the same task, different individuals exhibit markedly patterns of brain activity. This variability is often attributed volatile factors, such as task strategy or compliance. We propose that individual differences in responses are, a large degree, inherent and can be predicted from task-independent measurements collected at rest. Using set conditions, spanning several behavioral domains, we train simple model relates activity evaluate by predicting activation maps for...
The default mode network (DMN) of the brain consists areas that are typically more active during rest than task performance. Recently however, this has been shown to be activated by certain types tasks. Social cognition, particularly higher-order tasks such as attributing mental states others, suggested activate a at least partly overlapping with DMN. Here, we explore claim, drawing on evidence from meta-analyses functional MRI data and recent studies investigating structural connectivity...
Looking for Greener Pastures Humans, like other animals, have evolved to forage. Brain-imaging studies by Kolling et al. (p. 95 ) suggest that activity in the dorsal anterior cingulate cortex supplies a continuous signal of environmental richness predicted foraging theory. The exhibits frame reference is tied key decision whether engage with current choice or search alternatives. same strategy used when humans are making types decisions. In contrast, ventromedial prefrontal cortex, brain...
Controversy surrounds the role of temporoparietal junction (TPJ) area human brain. Although TPJ has been implicated both in reorienting attention and social cognition, it is still unclear whether these functions have same neural basis. Indeed, a precisely identifiable cortical region or cluster subregions with separate matter debate. Here, we examined structural functional connectivity TPJ, testing unitary heterogeneous profile conglomerate regions distinctive connectivity....
It has been suggested that variation in brain structure correlates with the sizes of individuals' social networks. Whether network size causes structure, however, is unknown. To address this question, we neuroimaged 23 monkeys had living groups set to different sizes. Subject comparison revealed larger caused increases gray matter mid-superior temporal sulcus and rostral prefrontal cortex increased coupling activity frontal cortex. Social size, therefore, contributes changes both function....
Despite the prominence of parietal activity in human neuroimaging investigations sensorimotor and cognitive processes, there remains uncertainty about basic aspects cortical anatomical organization. Descriptions cortex draw heavily on schemes developed other primate species, but validity such comparisons has been questioned by claims that are fundamental differences between humans primates. A scheme is presented for parcellation lateral into component regions basis connectivity functional...
The human dorsal frontal cortex has been associated with the most sophisticated aspects of cognition, including those that are thought to be especially refined in humans. Here we used diffusion-weighted magnetic resonance imaging (DW-MRI) and functional MRI (fMRI) humans macaques infer compare organization two species. Using DW-MRI tractography-based parcellation, identified 10 regions lying between inferior sulcus cingulate cortex. Patterns coupling each area rest brain were then estimated...
Significance Because of the interest in reward-guided learning and decision making, these neural mechanisms have been studied both humans monkeys. But whether how key brain areas correspond between two species has uncertain. Areas can be compared as a function circuits which they participate, estimated from patterns correlation activity measured with functional MRI. Taking such measurements 38 25 macaques, we identified fundamental similarities one human frontal area no monkey counterpart....
Brains use predictive models to facilitate the processing of expected stimuli or planned actions. Under a model, surprising (low probability) actions necessitate immediate reallocation resources, but they can also signal need update underlying model reflect changes in environment. Surprise and updating are often correlated experimental paradigms are, fact, distinct constructs that be formally defined as Shannon information (IS) Kullback-Leibler divergence (DKL) associated with an...
The causal role of an area within a neural network can be determined by interfering with its activity and measuring the impact. Many current reversible manipulation techniques have limitations preventing their application, particularly in deep areas primate brain. Here, we demonstrate that focused transcranial ultrasound stimulation (TUS) protocol impacts even brain areas: subcortical structure, amygdala (experiment 1), cortical region, anterior cingulate cortex (ACC, experiment 2),...
To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound stimulation (TUS) a promising non-invasive technique. date, investigations report short-lived neuromodulatory effects, but deliver on its full potential for research therapy, protocols are required that induce longer-lasting ‘offline’ changes. Here, we present TUS protocol modulates activation in macaques more than one hour after 40 s of stimulation, while circumventing auditory...
The right inferior frontal gyrus (rIFG) and the presupplementary motor area (pre-SMA) have been identified with cognitive control-the top-down influence on other brain areas when nonroutine behavior is required. It has argued that they "inhibit" habitual responses environmental changes mean a different response should be made. However, whether such "inhibition" can equated inhibitory physiological interactions unclear, as areas' relationship each anatomical routes by which movement...
Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational cross-species comparative neuroscience. Unfortunately, the technological methodological advances past two decades have outpaced accrual data, which particularly challenging given relatively few centers necessary facilities capabilities. The PRIMatE Data Exchange (PRIME-DE) addresses this challenge by aggregating independently acquired non-human magnetic resonance imaging...
We present a new software package with library of standardised tractography protocols devised for the robust automated extraction white matter tracts both in human and macaque brain. Using vivo data from Human Connectome Project (HCP) UK Biobank ex brain datasets, we obtain atlases, as well atlases tract endpoints on white-grey boundary, species. illustrate that our are against quality, generalisable across two species reflect known anatomy. further demonstrate they capture inter-subject...
In the absence of external stimuli or task demands, correlations in spontaneous brain activity (functional connectivity) reflect patterns anatomical connectivity. Hence, resting-state functional connectivity has been used as a proxy measure for structural and biomarker changes disease. To relate to physiological brain, it is important understand how depend on physical integrity tissue. The causal nature this relationship called into question by patient data suggesting that decreased does not...
Comparing the brains of related species faces challenges establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between primates. The approach uses white matter blueprints whole cortex based on set tracts that can be anatomically matched across species. provide common reference space allows us to navigate different species, identify homologous cortical areas, or transform maps from one...