A5038917187- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Alzheimer's disease research and treatments
- Ultrasound and Cavitation Phenomena
- Photoacoustic and Ultrasonic Imaging
- Functional Brain Connectivity Studies
- Comparative Animal Anatomy Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Primate Behavior and Ecology
- Infrared Thermography in Medicine
- Fetal and Pediatric Neurological Disorders
- Evolution and Paleontology Studies
- Glioma Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Multiple Sclerosis Research Studies
- Bone and Joint Diseases
- Neurological disorders and treatments
- Atomic and Subatomic Physics Research
- Pleistocene-Era Hominins and Archaeology
- Physiological and biochemical adaptations
- Advanced NMR Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Paleontology and Evolutionary Biology
Sorbonne Université
2016-2025
Centre National de la Recherche Scientifique
2015-2025
Institut du Cerveau
2016-2025
Inserm
2015-2025
Cognitive Neuroimaging Lab
2016-2024
Assistance Publique – Hôpitaux de Paris
2018-2023
Pitié-Salpêtrière Hospital
2013-2023
Fondation de l'Avenir
2015-2023
Sorbonne Paris Cité
2020-2022
Allen Institute for Brain Science
2022
To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound stimulation (TUS) a promising non-invasive technique. date, investigations report short-lived neuromodulatory effects, but deliver on its full potential for research therapy, protocols are required that induce longer-lasting ‘offline’ changes. Here, we present TUS protocol modulates activation in macaques more than one hour after 40 s of stimulation, while circumventing auditory...
Abstract In Parkinson’s disease, there is a progressive reduction in striatal dopaminergic function, and loss of neuromelanin-containing neurons increased iron deposition the substantia nigra. We tested hypothesis relationship between impairment system changes metabolism. Based on imaging data patients with prodromal early clinical we assessed spatiotemporal ordering such relationships sensorimotor, associative limbic territories nigrostriatal system. Patients disease (disease duration...
Abstract Preclinical diffusion MRI (dMRI) has proven value in methods development and validation, characterizing the biological basis of phenomena, comparative anatomy. While dMRI enables vivo non‐invasive characterization tissue, ex is increasingly being used to probe tissue microstructure brain connectivity. Ex several experimental advantages that facilitate high spatial resolution SNR images, cutting‐edge contrasts, direct comparison with histological data as a methodological validation....
OBJECTIVE The main limitation to the efficacy of chemotherapy for brain tumors is restricted access because limited permeability blood-brain barrier (BBB). Previous animal studies have shown that application pulsed ultrasound (US), in combination with intravenous injection microbubbles, can temporarily disrupt BBB deliver drugs normally cannot reach tissue. Although many previous been performed external focused US transducers, device described current work emits energy using an unfocused...
Abstract Background Temporary disruption of the blood-brain barrier (BBB) using pulsed ultrasound leads to clearance both amyloid and tau from brain, increased neurogenesis, mitigation cognitive decline in pre-clinical models Alzheimer’s disease (AD) while also increasing BBB penetration therapeutic antibodies. The goal this pilot clinical trial was investigate safety efficacy approach patients with mild AD an implantable device. Methods An implantable, 1-MHz device (SonoCloud-1) implanted...
Abstract Polymeric capsules with a thick shell made of biodegradable and biocompatible polymer liquid core perfluorooctyl bromide (PFOB) were evaluated for stability as well ultrasound magnetic resonance imaging (MRI) contrast enhancement. The method preparation allows the mean capsule diameter to be regulated between 70 nm 25 µm thickness‐to‐radius ratio from 0.25 0.54. Capsule remains stable at 37 °C in phosphate buffer least 4 6 h nanocapsules microcapsules, respectively. vitro...
Cerebral aging is often associated with the occurrence of neurodegenerative diseases leading to dementia. Animal models are critical elucidate mechanisms dementia and evaluate neuroprotective drugs. Rats that received intracerebroventricular injection streptozotocin (icv-STZ) have been reported as a model In these animals, this drug induces oxidative stress brain glucose metabolism impairments insulin signal transduction failure. These be involved in pathogenesis Alzheimer's disease other...
The basal ganglia are key structures for motor, cognitive and behavioral functions. They undergo several changes with aging disease, such as Parkinson's or Huntington's example. Iron accumulation in is often related to these diseases, which conventionally monitored by the transverse relaxation rate (R2 *). Quantitative susceptibility mapping (QSM) a novel contrast mechanism MRI produced adding information taken from phase of MR signal its magnitude. It has been shown be more sensitive subtle...
Transcranial focus ultrasound applications applied under MRI-guidance benefit from unrivaled monitoring capabilities, allowing the recording of real-time anatomical information and biomarkers like temperature rise and/or displacement induced by acoustic radiation force. Having both these measurements could allow for better targeting brain structures, with improved therapy safety. We investigated use a novel MRI-pulse sequence described previously in Bour et al., (2017) to quantify changes...
<title>Abstract</title> The vascular system regulates brain clearance through arterial blood flow and lymphatic drainage of cerebrospinal fluid (CSF). Idiopathic intracranial hypertension (IIH), characterized by elevated pressure dural venous sinus stenoses, can be treated restoring via stenting, suggesting a role for in clearance. Using magnetic resonance imaging (MRI) IIH patients healthy controls, we identified that stenoses were associated with impaired drainage, perivenous retention,...
Abstract The value of preclinical diffusion MRI (dMRI) is substantial. While dMRI enables in vivo non‐invasive characterization tissue, ex increasingly being used to probe tissue microstructure and brain connectivity. Ex has several experimental advantages including higher SNR spatial resolution compared studies, enabling more advanced contrasts for improved connectivity characterization. Another major advantage the direct comparison with histological data, as a crucial methodological...