A5088689012- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Single-cell and spatial transcriptomics
- Memory and Neural Mechanisms
- Immune cells in cancer
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Immune Response and Inflammation
- Neonatal and fetal brain pathology
- Climate Change Communication and Perception
- Fibroblast Growth Factor Research
- Health, Environment, Cognitive Aging
- Nuclear Receptors and Signaling
- Bioinformatics and Genomic Networks
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Neuroscience and Music Perception
- Amyotrophic Lateral Sclerosis Research
- Medicinal Plants and Bioactive Compounds
- Science Education and Perceptions
- Mental Health Research Topics
- Epigenetics and DNA Methylation
University of Washington
2017-2025
University of Michigan–Ann Arbor
2011-2017
Stanford University
2009-2010
Convergent data from various scientific approaches strongly implicate cerebellar systems in nonmotor functions. The functional anatomy of these has been pieced together disparate sources, such as animal studies, lesion studies humans, and structural imaging humans. To better define this distinct anatomy, the current study we delineate role cerebellum several simultaneously same subjects using resting state connectivity MRI. Independent component analysis was applied to two independent...
Little is known about the neural abnormalities underlying generalized anxiety disorder (GAD). Studies in other disorders have implicated amygdala, but work GAD has yielded conflicting results. The amygdala composed of distinct subregions that interact with dissociable brain networks, which been studied only experimental animals. A functional connectivity approach at subregional level may therefore yield novel insights into GAD.To determine whether patterns can be reliably identified for...
Objective Clinical data suggest that abnormalities in the regulation of emotional processing contribute to pathophysiology generalized anxiety disorder, yet these remain poorly understood at neurobiological level. The authors recently reported healthy volunteers pregenual anterior cingulate regulates conflict on a trial-by-trial basis by dampening activity amygdala. also showed this process is specific emotional, compared nonemotional, conflict. Here examined whether form noninstructed...
Abstract Microglia, the innate immune cells of brain, influence Alzheimer’s disease (AD) progression and are potential therapeutic targets. However, microglia exhibit diverse functions, regulation which is not fully understood, complicating therapeutics development. To better define transcriptomic phenotypes gene regulatory networks associated with AD, we enriched for nuclei from 12 AD 10 control human dorsolateral prefrontal cortices (7 males 15 females, all aged >60 years) before...
Background Generalized social anxiety disorder (gSAD) is characterized by exaggerated amygdala reactivity to signals of threat, but if and how the interacts with functionally anatomically connected prefrontal cortex (PFC) remains largely unknown. Recent evidence points aberrant connectivity medial PFC in gSAD at rest, it difficult attribute functional relevance without context threat processing. Here, we address this studying amygdala–frontal during viewing fearful faces rest patients....
Alzheimer's Disease (AD) is characterized by the accumulation of extracellular amyloid-β (Aβ) as well CNS and systemic inflammation. Microglia, myeloid cells resident in CNS, use microRNAs to rapidly respond inflammatory signals. MicroRNAs (miRNAs) modulate responses microglia, miRNA profiles are altered disease patients. Expression pro-inflammatory miRNA, miR-155, increased AD brain. However, role miR-155 pathogenesis not well-understood. We hypothesized that participates pathophysiology...
Significance Molecular mechanisms mediating negative emotion and contributing to major depression remain elusive: here, we present evidence implicating fibroblast growth factor 9 (FGF9) as a key mediator. We use whole-transcriptome studies of postmortem human tissue demonstrate that FGF9 is elevated in depression. Reverse translation animal both endogenous exogenous promotes anxiety- depression-like behavior. Conversely, localized blockade expression decreases anxiety To our knowledge, this...
Late-onset Alzheimer's disease (LOAD) has a complex genomic architecture with risk variants in multiple pathways, including the endolysosomal network (ELN). Whether genetic specific pathways correlates corresponding biological dysfunction remains largely unknown. We developed an pathway-specific polygenic score (ePRS) using 13 established AD GWAS loci containing ELN genes. investigated association between ePRS and neuropathology, then examined cell-specific morphology transcriptomic profiles...
Microglia are the innate immune cells of central nervous system that adopt rapid functional changes in response to Damage Associated Molecular Patterns, including aggregated β-Amyloid (Aβ) found Alzheimer's disease (AD). microRNAs (miRNAs) post-transcriptional modulators influence timing and magnitude microglia inflammatory responses by downregulating expression effectors. Recent studies implicate miR-155, a miRNA known regulate responses, pathogenesis neurodegenerative disorders multiple...
Background: Early-onset familial Alzheimer disease (EOFAD) is caused by heterozygous variants in the presenilin 1 (PSEN1), 2 (PSEN2), and APP genes. Decades after their discovery, mechanisms which these genes cause Alzheimer’s (AD) or promote AD progression are not fully understood. While it established that (PS) enzymatic activity produces amyloid-β (Aβ), PSs also regulate numerous other cellular functions, some of intersect with known pathogenic drivers neurodegeneration. Accumulating...
Organotypic brain slice models are an ideal technological platform to investigate therapeutic options for hypoxic-ischemic (HI) injury, a leading cause of morbidity and mortality in neonates. The exhibits regional differences the response HI injury vivo. This can be modeled using organotypic slices, which maintain three-dimensional structures reflect response. Here, we developed whole hemisphere (OWH) culture model gyrencephalic ferret at developmental stage equivalent full-term human infant...
Microglia maintain brain health and play important roles in disease injury. Despite the known ability of microglia to proliferate, precise nature population or populations capable generating new adult remains controversial. We identified Prominin-1 (Prom1; also as CD133) a putative cell surface marker committed myeloid progenitor cells. demonstrate that Prom1-expressing cells isolated from mixed cortical cultures will generate <i>in vitro</i>. To determine whether vivo</i>, we used tamoxifen...
Academic writers and presenters need concrete activities to help them learn how communicate more effectively. We describe such a tool, called “Half-Life Your Message,” which is adapted from commonly used improvisational theater game can be applied in three minutes distill central thesis for any communication effort. Users increase the value provided by Half-Life Message scaffolding its application with an introduction opportunity self-reflect debrief. emphasize tool’s utility based on our...
With climate change, natural disasters such as hurricanes, earthquakes and tsunamis are occurring worldwide with greater frequency. This is at a time when an expanding older population living in cities, where it proving one of the most vulnerable groups crisis hits, from evacuation to recovery. Here, Francesca Birks Katherine Prater ArupForesight + Research Innovation consider design solutions that enable liveability cities for ageing residents periods disaster, well stability.
Abstract Microglia contribute to Alzheimer’s Disease (AD) progression and are candidate therapeutic targets. Human microglia exhibit an array of transcriptional phenotypes implying that accurate manipulation microglial function will require clarity their molecular states context dependent regulation. To increase the number analyzed per subject we employed fluorescence activated nuclei sorting prior single-nucleus RNA-seq on human prefrontal cortices. We observed previously unrecognized in...
Single-cell transcriptomics, epigenomics, and other 'omics applied at single-cell resolution can significantly advance hypotheses understanding of glial biology. Omics technologies are revealing a large growing number new cell subtypes, defined by their gene expression profile. These subtypes have significant implications for function, cell-cell communications, glia-specific changes between homeostasis conditions such as neurological disease. For many, the training in how to analyze,...