A5083085688- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- Mental Health Research Topics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Child and Adolescent Psychosocial and Emotional Development
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Bipolar Disorder and Treatment
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Neurobiology of Language and Bilingualism
- Neural dynamics and brain function
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological disorders and treatments
- Cognitive and developmental aspects of mathematical skills
- Neurological Disease Mechanisms and Treatments
- Healthcare professionals’ stress and burnout
- Neuroscience and Music Perception
- Health Systems, Economic Evaluations, Quality of Life
- Stress Responses and Cortisol
- EEG and Brain-Computer Interfaces
Stanford University
2011-2025
Palo Alto University
2023-2024
Medical University of South Carolina
2023-2024
Neurosciences Institute
2024
Oregon Health & Science University
2024
Northwestern University
2013-2022
University of Arizona
2022
Texas Tech University Health Sciences Center
2021
Texas Tech University
2021
Veterans Health Administration
2018
Math anxiety is a negative emotional reaction to situations involving mathematical problem solving. has detrimental impact on an individual’s long-term professional success, but its neurodevelopmental origins are unknown. In functional MRI study 7- 9-year-old children, we showed that math was associated with hyperactivity in right amygdala regions important for processing emotions. addition, found reduced activity posterior parietal and dorsolateral prefrontal cortex involved reasoning....
BackgroundBrain amyloidosis does not invariably predict dementia. We hypothesized that high soluble 42-amino acid β amyloid (Aβ42) peptide levels are associated with normal cognition and hippocampal volume despite increasing brain amyloidosis.MethodsThis cross-sectional study of 598 amyloid-positive participants in the Alzheimer's Disease Neuroimaging Initiative cohort examined whether Aβ42 higher (NC) individuals compared to mild cognitive impairment (MCI) disease (AD) this relationship...
The ability to temporarily prioritize rapid and vigilant reactions over slower higher-order cognitive functions is essential for adaptive responding threat. This reprioritization believed reflect shifts in resource allocation between large-scale brain networks that support these functions, including the salience executive control networks. However, how changes communication within such dynamically unfold as a function of threat-related arousal remains unknown. To address this issue, we...
Abstract Developmental dyscalculia ( DD ) is marked by specific deficits in processing numerical and mathematical information despite normal intelligence IQ reading ability. We examined how brain circuits used young children with to solve simple addition subtraction problems differ from those typically developing TD who were matched on age, , ability, working memory. Children slower less accurate during problem solving than children, especially impaired their ability problems. showed...
Children's gains in problem-solving skills during the elementary school years are characterized by shifts mix of approaches, with inefficient procedural strategies being gradually replaced direct retrieval domain-relevant facts. We used a well-established procedure for strategy assessment arithmetic problem solving to investigate neural basis this critical transition. indexed behavioral use focusing on frequency and examined changes brain activity connectivity associated fluency second-...
The human brain undergoes protracted development, with dramatic changes in expression and regulation of emotion from childhood to adulthood. amygdala is a structure that plays pivotal role emotion-related functions. Investigating developmental characteristics the associated functional circuits children important for understanding how processing matures developing brain. basolateral (BLA) centromedial (CMA) are two major amygdalar nuclei contribute distinct functions via their unique pattern...
Abstract Anhedonia, the reduced ability to experience pleasure in response otherwise rewarding stimuli, is a core symptom of major depressive disorder (MDD). Although posterior ventromedial prefrontal cortex (pVMPFC) and its functional connections have been consistently implicated MDD, their roles anhedonia remain poorly understood. Furthermore, it unknown whether primarily associated with intrinsic ‘resting-state’ pVMPFC connectivity or an inability modulate context-specific manner. To...
Characterization of early tau deposition in individuals with preclinical Alzheimer disease (AD) is critical for prevention trials that aim to select at risk AD and halt the progression disease.To evaluate prevalence cortical positron emission tomography (PET) heterogeneity a large cohort clinically unimpaired older adults elevated β-amyloid (A+).This cross-sectional study examined prerandomized PET, amyloid structural magnetic resonance imaging, demographic, cognitive data from Anti-Amyloid...
Abstract Background APOE variants are strongly associated with abnormal amyloid aggregation and additional direct effects of on tau reported in animal human cell models. The degree to which these present humans when individuals clinically unimpaired (CU) but have (Aβ+) remains unclear. Methods We analyzed data from CU the Anti-Amyloid Treatment Asymptomatic AD (A4) Longitudinal Evaluation Amyloid Risk Neurodegeneration (LEARN) studies. PET were available for 4486 participants (3163 Aβ-, 1323...
Abstract INTRODUCTION Amyloid positron emission tomography (PET) is increasingly available for diagnosis of Alzheimer`s disease (AD); however, its practical implications in heterogenous cohorts are debated. METHODS PET from 890 National Coordinating Center participants with up to 10 years post‐PET follow was analyzed. Cox proportional hazards and linear mixed models were used investigate amyloid burden prediction etiology prospective functional status cognitive decline. RESULTS positivity...
Abstract Background The recent promise of disease-modifying therapies for Alzheimer’s disease (AD) has reinforced the need accurate biomarkers early detection, diagnosis and treatment monitoring. Advances in development novel blood-based AD have revealed that plasma levels tau phosphorylated at various residues are specific sensitive to dementia. However, currently available tests shortcomings access, throughput, scalability limit widespread implementation. Methods We evaluated diagnostic...
Speech impediments are a prominent yet understudied symptom of Parkinson's disease (PD). While the subthalamic nucleus (STN) is an established clinical target for treating motor symptoms, these interventions can lead to further worsening speech. The interplay between dopaminergic medication, STN circuitry, and their downstream effects on speech in PD not fully understood. Here, we investigate effect medication circuitry probe its association with cognitive functions patients. We found that...
Abstract Objective More than half of neurodegenerative disease patients have multiple pathologies at autopsy; however, most receive one diagnosis during life. We used the α‐synuclein seed amplification assay (αSyn‐SAA) and CSF biomarkers for amyloidosis Alzheimer's (AD) neuropathological change (ADNC) to determine frequency co‐pathologies in participants clinically diagnosed with Lewy body (LB) or AD. Methods Using receiver operating characteristic analyses on retrospective samples from 150...
Tau PET has allowed for critical insights into in vivo patterns of tau accumulation and change individuals early the Alzheimer's disease (AD) continuum. A key methodological step analyses is selection a reference region, but there not yet consensus on optimal region especially longitudinal analyses. This study examines how influences results related to stage at baseline over time. Longitudinal flortaucipir ([18F]-AV1451) scans were examined using several common regions (e.g., eroded...
Rates of tau accumulation in cognitively unimpaired older adults are subtle, with magnitude and spatial patterns varying recent reports. Regional also likely varies the degree to which is amyloid-β-dependent. Thus, there a need evaluate pattern consistency across multiple cohorts how these relate amyloid burden, order design optimal end points for clinical trials. Using three large adults, Anti-Amyloid Treatment Asymptomatic Alzheimer's companion study, Longitudinal Evaluation Amyloid Risk...
Abstract INTRODUCTION Amyloid positron emission tomography (PET) acquisition timing impacts quantification. METHODS In florbetaben (FBB) PET scans of 245 adults with and without cognitive impairment, we investigated the impact post‐injection time on Centiloids (CLs) across five reference regions. CL equations for FBB were derived using standard methods, data collected between 90 110 min paired Pittsburgh compound B data. Linear mixed models t ‐tests evaluated increases. RESULTS values...
Abstract 18 F-Florbetaben (FBB) uptake in the supratentorial cortex is indicative of amyloid positivity. Due to PET’s low spatial resolution, image noise, and spill-over signal from adjacent white-matter into gray-matter, there are inconsistencies ratings among trained readers. A set 264 (amyloid) PET/MRI exams were reconstructed using conventional ordered subset expectation maximization (OSEM) method MR-guided block sequential regularized (MRgBSREM) method. Images patients by OSEM rated 3...