A5071605818- Diet and metabolism studies
- Eating Disorders and Behaviors
- Neurological Complications and Syndromes
- Functional Brain Connectivity Studies
- Music Therapy and Health
- Neuroscience and Music Perception
- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
- Pain Management and Placebo Effect
- Alzheimer's disease research and treatments
- Neurological and metabolic disorders
- Regulation of Appetite and Obesity
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Pain Mechanisms and Treatments
- Obesity, Physical Activity, Diet
- Genetic Syndromes and Imprinting
- Autism Spectrum Disorder Research
- Pharmacological Effects and Toxicity Studies
- Musculoskeletal pain and rehabilitation
- Acute Ischemic Stroke Management
- Renal Transplantation Outcomes and Treatments
- Pediatric Pain Management Techniques
- Cancer-related cognitive impairment studies
- Dialysis and Renal Disease Management
University of Kansas Medical Center
2015-2024
Imaging Center
2015-2024
University of Kansas
2011-2024
Alzheimer’s Disease Neuroimaging Initiative
2016-2022
Tufts Medical Center
2020
To evaluate brain activation in response to common food and nonfood logos healthy weight obese children.Ten children (mean body mass index the 50th percentile) 10 97.9th completed self-report measures of self-control. They then underwent functional magnetic resonance imaging while viewing logos.Compared with children, showed significantly less bilateral middle/inferior prefrontal cortex, an area involved cognitive control.When shown logos, than regions associated control. This provides...
Rationale & ObjectiveKidney disease negatively affects cognition. We assessed the effect of kidney transplantation (KT) on different cognitive domains.Study DesignProspective cohort study.Setting ParticipantsWe examined pre- to post-KT cognition in patients waitlisted for KT at an academic center.PredictorsTransplant status. measured function pre-KT (n=101), three months (n=78), and 1-year (n=83).OutcomesOur primary outcome was change post-KT. used standard neuropsychological tests assess...
Abstract INTRODUCTION Amyloid positron emission tomography (PET) is increasingly available for diagnosis of Alzheimer`s disease (AD); however, its practical implications in heterogenous cohorts are debated. METHODS PET from 890 National Coordinating Center participants with up to 10 years post‐PET follow was analyzed. Cox proportional hazards and linear mixed models were used investigate amyloid burden prediction etiology prospective functional status cognitive decline. RESULTS positivity...
Branding and advertising have a powerful effect on both familiarity preference for products, yet no neuroimaging studies examined neural response to logos in children. Food is particularly pervasive effective manipulating choices The purpose of this study was examine how healthy children's brains respond common food other logos. A pilot validation first conducted with 32 children select the most culturally familiar logos, match non-food valence intensity. new sample 17 weight were then...
This functional magnetic resonance imaging (fMRI) pilot study identified whether breakfast consumption would alter the neural activity in brain regions associated with food motivation and reward overweight "breakfast skipping" (BS) adolescent girls examined increased protein at lead to additional alterations. Ten (Age: 15 ± 1 years; BMI percentile 93 1%; BS 5 1×/week) completed 3 testing days. Following day, participants were provided with, randomized order, normal (NP; 18 g protein) or...
End-stage renal disease (ESRD) is a with an aging population and high prevalence of cognitive impairment affecting quality life, health care costs mortality. Structural changes in the brain decreased white matter integrity have been observed ESRD. Understanding cognition associated structure after transplantation can help define mechanisms underlying ESRD.We conducted prospective, observational cohort study ESRD patients listed for followed them post-transplantation. We assessed their...
Few studies have examined brain changes in response to effective weight loss; none compared different methods of weight-loss intervention. Functional associated with a behavioral loss intervention those bariatric surgery were compared.Fifteen obese participants recruited prior adjustable gastric banding and 16 diet Groups matched for demographics amount lost. magnetic resonance imaging scans (visual food motivation paradigm while hungry following meal) conducted before 12 weeks after...
Background Anterior cingulate cortex (ACC) and striatum are part of the emotional neural circuitry implicated in major depressive disorder (MDD). Music is often used for emotion regulation, pleasurable music listening activates dopaminergic system brain, including ACC. The present study uses functional MRI (fMRI) an nonmusical musical stimuli paradigm to examine how processing emotionally provocative auditory altered within ACC depression. Method Nineteen MDD 20 never-depressed (ND) control...
Abstract Long‐chain polyunsaturated fatty acids ( LCPUFA ) have been shown to be necessary for early retinal and brain development, but long‐term cognitive benefits of in infancy not definitively established. The present study sought determine whether supplementation during the first year life would result group differences behavior event‐related potentials ERP s) while performing a task requiring response inhibition (Go/No‐Go) at 5.5 years age. As newborns, 69 children were randomly...
Abstract The present study sought to determine whether supplementation of long‐chain polyunsaturated fatty acids (LCPUFA) during the first year life influenced brain function, structure, and metabolism at 9 years age. Newborns were randomly assigned consume formula containing either no LCPUFA (control) or with 0.64% total as arachidonic acid (ARA; 20:4n6) variable amounts docosahexaenoic (DHA; 22:6n3) (0.32%, 0.64%, 0.96% acids) from birth 12 months. At age (±0.6), 42 children enrolled in a...
Abstract To investigate the experiences of adolescents with chronic pain who participated in an intensive interdisciplinary treatment program, this secondary study analyzes themes that emerged regarding spontaneous utilization music coping strategies for pain. During research interviews focused on skills and engagement, participants spontaneously reported using as effective strategy managing A deductive thematic analysis revealed key related to their usage, including a distractor, motivator...
Because Music Based Interventions (MBIs) are not standard of care for Alzheimer's disease and related dementias (AD/ADRD), it is likely that the application them in different communities differs widely. Additionally, there no standardized use personalized music listening group activities. The purpose this study was to assess current long-term communities, identify trends patterns record observed benefits provides. This utilized a qualitative research approach using semi-structured interviews...
Objectives/Goals: Research supports the use of music to improve care and well-being adults living with dementia; however, practice implementation in elder communities is not regulated. The goal this qualitative study was survey Northeast Kansas determine people dementia. Methods/Study Population: We interviewed staff (n = 10) at five City Metro area observed musical activities artifacts shared spaces within each community. Interview questions included details frequency purpose using music,...
Abstract Despite behavioral differences between genetic subtypes of Prader–Willi syndrome (PWS), no studies have been published characterizing brain structure in these subgroups. Our goal was to examine the phenotype common PWS [chromosome 15q deletions and maternal uniparental disomy 15 (UPD)]. Fifteen individuals with due a typical deletion [(DEL) type I; n = 5, II; 10], eight UPD, 25 age‐matched healthy‐weight (HWC) participated structural magnetic resonance imaging (MRI) scans. A custom...
Objective Obese children demonstrate less activation in prefrontal regions associated with self‐control and inhibition when presented food cues advertisements. This study evaluates the differences between obese healthy weight resting‐state functional connectivity to these brain regions. Methods Seed bilateral middle frontal gyri were chosen based on previous task‐based analysis showing children's responses food‐associated stimuli. Functional seed was measured scans collected lean undergoing...
Objective Changes in food-cue neural reactivity associated with behavioral and surgical weight loss interventions have been reported. Resting functional connectivity represents tonic activity that may contribute to success. This study explores whether intervention type is differences after loss. Methods Fifteen participants obesity were recruited prior adjustable gastric banding surgery. Thirteen demographically matched selected from a separate diet intervention. Resting-state magnetic...
Cerebrovascular dysfunction likely contributes causally to Alzheimer’s disease (AD). The strongest genetic risk factor for late-onset AD, Apolipoprotein E4 ( APOE4), may act synergistically with vascular cause dementia. Therefore, interventions that improve health, such as exercise, be particularly beneficial APOE4 carriers. We assigned cognitively normal adults (65–87 years) an aerobic exercise intervention or education only. Arterial spin labeling MRI measured hippocampal blood flow (HBF)...
Both the APOE ε4 and TOMM40 rs10524523 ("523") genes have been associated with risk for Alzheimer's disease (AD) neuroimaging biomarkers of AD. No studies investigated relationship TOMM40'523-APOE on structural complexity brain in AD individuals. We quantified morphology multiple cortical attributes individuals mild cognitive impairment (MCI) AD, then tested whether or poly-T genotypes were related to morphological cognitively unimpaired (CU) MCI/AD identified several AD-specific phenotypes...
Obesity is fundamentally a disorder of energy balance. In obese individuals, more consumed than expended, leading to excessive weight gain through the accumulation adipose tissue. Complications arising from obesity, including cardiovascular disease, elevated peripheral inflammation, and development Type II diabetes, make obesity one preventable causes morbidity mortality. Thus, it paramount importance both individual public health that we understand neural circuitry underlying behavioral...
Significance Statement Kidney disease is accompanied by structural and physiologic brain abnormalities increased risk of dementia stroke. Because RRT with dialysis does not normalize these abnormalities, the authors evaluated possible benefit kidney transplantation. Using magnetic resonance imaging methods to measure before after transplantation, they demonstrated that this intervention normalizes cerebral blood flow, neurochemical concentrations, white matter integrity. They also found...
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst enlargement, leading to failure. Sirtuin-1 upregulated in ADPKD and accelerates progression deacetylating p53. Niacinamide a dietary supplement that inhibits sirtuins at high doses.
A variety of quality control (QC) approaches are employed in resting-state functional magnetic resonance imaging (rs-fMRI) to determine data and ultimately inclusion or exclusion a fMRI set group analysis. Reliability rs-fMRI can be improved by censoring "scrubbing" volumes affected motion. While preserves the integrity participant-level data, including excessively censored sets analyses may add noise. Quantitative motion-related metrics frequently reported literature; however, qualitative...