A5041837769- Alzheimer's disease research and treatments
- Mathematical Analysis and Transform Methods
- Dementia and Cognitive Impairment Research
- Image and Signal Denoising Methods
- Geometric Analysis and Curvature Flows
- Geometry and complex manifolds
- Advanced Algebra and Geometry
- Neuroinflammation and Neurodegeneration Mechanisms
- Fault Detection and Control Systems
- Hydrocarbon exploration and reservoir analysis
- Bioinformatics and Genomic Networks
- Advanced Differential Geometry Research
- Memory and Neural Mechanisms
- Seismic Imaging and Inversion Techniques
- Inflammation biomarkers and pathways
- Parkinson's Disease Mechanisms and Treatments
- Advanced Data Processing Techniques
- Adaptive optics and wavefront sensing
- Control Systems and Identification
- Space Satellite Systems and Control
- Neuroscience and Neuropharmacology Research
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Retinal Development and Disorders
Stanford University
1995-2025
Neurosciences Institute
2023-2025
Louisiana State University Agricultural Center
2023
Washington University in St. Louis
2004-2022
DePaul University
2022
Universidad Autónoma de Madrid
2022
McGill University
2011-2019
Montreal Neurological Institute and Hospital
2019
Los Alamos National Laboratory
2017
Ecological Society of America
2017
Abstract Animal studies show aging varies between individuals as well organs within an individual 1–4 , but whether this is true in humans and its effect on age-related diseases unknown. We utilized levels of human blood plasma proteins originating from specific to measure organ-specific differences living individuals. Using machine learning models, we analysed 11 major estimated organ age reproducibly five independent cohorts encompassing 5,676 adults across the lifespan. discovered nearly...
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer's disease (AD), with recent proteomic studies highlighting disrupted glial in AD. We report that inhibition indoleamine-2,3-dioxygenase 1 (IDO1), which metabolizes tryptophan to kynurenine (KYN), rescues hippocampal memory function mouse preclinical models AD by restoring astrocyte metabolism. Activation astrocytic IDO1 amyloid β and tau oligomers increases KYN suppresses glycolysis an aryl hydrocarbon...
Objective The purpose of this study was to determine the sensitivity and specificity α‐synuclein seed amplification assay (αSyn‐SAA) in antemortem postmortem cerebrospinal fluid (CSF) autopsy‐confirmed patients with different distributions pathological αSyn, co‐pathologies, clinical diagnoses. Methods αSyn‐SAA used test CSF samples from 119 subjects a variety syndromes standardized neuropathological examinations Oregon Health Science University (OHSU) California San Diego (UCSD; 56...
The integration of quantitative trait loci (QTL) with disease genome-wide association studies (GWAS) has proven successful at prioritizing candidate genes disease-associated loci. QTL mapping mainly been focused on multi-tissue expression or plasma protein (pQTL). Here we generated the largest-to-date cerebrospinal fluid (CSF) pQTL atlas by analyzing 7,028 proteins in 3,107 samples. We identified 3,373 independent study-wide associations for 1,961 proteins, including 2,448 novel pQTLs which...
A major impediment to the understanding and modeling of propagation through backscattering emission from vegetation canopies has been lack canopy attenuation data as a function frequency, incidence angle, polarization configuration. This paper presents results experiments conducted for winter wheat soybeans in late spring early summer 1984. Attenuation were acquired at 1.55, 4.75, 10.2 GHz horizontal vertical polarizations angles near 20° 50°. In addition, decapitation soybean defoliation...
On etudie le spectre du laplacien sur des varietes de Heisenberg riemanniennes compactes, la forme (Γ\H n , g) ou H est groupe a (2n+1) dimensions, Γ un sous-groupe discret uniforme et g une metrique Riemann Γ\H dont relevement H, invariant gauche
Parkinson's disease is the second most common neurodegenerative after Alzheimer's and affects 1% of population above 60 years old. Although commonly manifests with motor symptoms, a majority patients subsequently develop cognitive impairment, which often progresses to dementia, major cause morbidity disability. characterized by α-synuclein accumulation that frequently associates amyloid-β tau fibrils, hallmarks neuropathological changes; this co-occurrence suggests onset decline in may be...
Abstract Background The recent promise of disease-modifying therapies for Alzheimer’s disease (AD) has reinforced the need accurate biomarkers early detection, diagnosis and treatment monitoring. Advances in development novel blood-based AD have revealed that plasma levels tau phosphorylated at various residues are specific sensitive to dementia. However, currently available tests shortcomings access, throughput, scalability limit widespread implementation. Methods We evaluated diagnostic...
Abstract Changes in Amyloid-β (A), hyperphosphorylated Tau (T) brain and cerebrospinal fluid (CSF) precedes AD symptoms, making CSF proteome a potential avenue to understand the pathophysiology facilitate reliable diagnostics therapies. Using AT framework three-stage study design (discovery, replication, meta-analysis), we identified 2,173 proteins dysregulated AD, that were further validated third totally independent cohort. Machine learning was implemented create validate highly accurate...
Abstract Objective More than half of neurodegenerative disease patients have multiple pathologies at autopsy; however, most receive one diagnosis during life. We used the α‐synuclein seed amplification assay (αSyn‐SAA) and CSF biomarkers for amyloidosis Alzheimer's (AD) neuropathological change (ADNC) to determine frequency co‐pathologies in participants clinically diagnosed with Lewy body (LB) or AD. Methods Using receiver operating characteristic analyses on retrospective samples from 150...
A wavelet with composite dilations is a function generating an orthonormal basis or Parseval frame for <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper L squared left-parenthesis double-struck upper R Superscript n Baseline right-parenthesis"> <mml:semantics> <mml:mrow> <mml:msup> <mml:mi>L</mml:mi> <mml:mn>2</mml:mn> </mml:msup> <mml:mo stretchy="false">(</mml:mo> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi...
Abstract A new computer program architecture for the solution of finite elemet systems using concurrent processing is presented. The basic approach involves automatic splitting an arbitrary spatial domain. Processors are dynamically re‐assigned during several phases analysis. Direct and iterative strategies considered. Computational algorithms element dynamic analysis large‐scale structural problems that exploit features MIMD computers implemented in modules around architecture. Also, with...
A simply connected solvable Lie group <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper R"> <mml:semantics> <mml:mi>R</mml:mi> <mml:annotation encoding="application/x-tex">R</mml:annotation> </mml:semantics> </mml:math> </inline-formula> together with a left-invariant Riemannian metric alttext="g"> <mml:mi>g</mml:mi> encoding="application/x-tex">g</mml:annotation> is called (simply connected) solvmanifold. Two solvmanifolds...
We consider a bilinear control system on $\mathbb{R}_0^n = \mathbb{R}^n - \{ 0\} $\[\frac{{dx}}{{dt}}(A_0 + \sum\limits_{i 1}^r {u_i (t)A_i } )x,\] where $x \in ,A_0$, $A_1 , \cdots ,A_r $ are $n \times n$ real matrices, $\mathfrak{g}$ is the Lie algebra they generate, and $u_1 (t), ,u_r (t)$ valued functions. Although there exists standard rank condition in terms of g which Sussman Jurdjevic have shown to be sufficient guarantee accessibility, it primarily theoretical interest, being...
In Alzheimer disease (AD), the accumulation of amyloid beta (Aβ) begins decades before cognitive symptoms and progresses from intraneuronal material to extracellular plaques. To date, however, precise mechanism by which early buildup Aβ peptides leads dysfunction remains unknown. Here, we investigate impact on temporal frontal lobe dysfunction. We compared performance McGill-R-Thy1-APP transgenic AD rats with wild-type littermate controls a visual discrimination task using touchscreen...