A5094118814- Inflammation biomarkers and pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
Stanford University
2024
INTRODUCTION: Intracranial hemorrhage and infection during the perinatal period are known risk factors for neonatal seizures, with up to 25% of patients seizures developing epilepsy later in life. However, underlying mechanisms that facilitate development following provoked remain unclear. METHODS: A neuron-astrocyte coculture system was employed model cortical characterize combinatorial effects serum cytokine exposures on network activity synchrony. Cortical neurons isolated from embryonic...
SUMMARY Human genetics implicate defective myeloid responses in the development of late onset, age-associated Alzheimer’s disease (AD). Aging is characterized by a decline metabolism that triggers maladaptive, neurotoxic immune responses. TREM1 an amplifier pro-inflammatory responses, and here we find Trem1 deficiency prevents age-dependent changes metabolism, inflammation, hippocampal memory function. rescues declines ribose-5P, glycolytic intermediate precursor for purine, pyrimidine, NAD...
<title>Abstract</title> Parkinson’s disease (PD) is a complex multisystem disorder clinically characterized by motor, non-motor, and premotor manifestations. Pathologically, PD involves neuronal loss in the substantia nigra, striatal dopamine deficiency, accumulation of intracellular inclusions containing aggregates α-synuclein. Recent studies demonstrate that associated with dysregulated metabolic flux through kynurenine pathway (KP), which tryptophan converted to (KYN), KYN subsequently...