A5052853323- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Inflammation biomarkers and pathways
- Glioma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Immune cells in cancer
- Tryptophan and brain disorders
- S100 Proteins and Annexins
- Monoclonal and Polyclonal Antibodies Research
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Child Abuse and Trauma
- T-cell and B-cell Immunology
- Intensive Care Unit Cognitive Disorders
- Diversity and Career in Medicine
- Transcranial Magnetic Stimulation Studies
- Caveolin-1 and cellular processes
- Neural and Behavioral Psychology Studies
- Adenosine and Purinergic Signaling
- Inflammasome and immune disorders
- Functional Brain Connectivity Studies
Stanford University
2018-2024
Washington University in St. Louis
2023
Manchester Academic Health Science Centre
2017-2021
University of Manchester
2014-2021
Stanford Medicine
2019-2021
Palo Alto University
2019
Tallaght University Hospital
2014
Trinity College Dublin
2011-2014
St. James's Hospital
2014
<h3>Background:</h3> Childhood maltreatment has been found to play a crucial role in the development of psychiatric disorders. However, whether childhood is associated with structural brain changes described for major depressive disorder (MDD) still matter debate. The aim this study was investigate patients MDD and history display more than without or healthy controls. <h3>Methods:</h3> Patients controls experience were investigated using high-resolution magnetic resonance imaging (MRI),...
at the Aβ plaques locations, while NeuN labelling revealed an age-dependent decrease in hippocampal neuron number both genotypes.Behavioural assessment using novel object recognition task that WT & TgF344-AD animals discriminated from familiar 3 m and 6 of age.However, low levels exploration observed genotypes later time-points resulted neither genotype successfully completing task.Deficits social interaction were only animals.By vivo MRS, we showed a neuronal marker N-acetyl-aspartate...
There is a need to identify clinically useful biomarkers in major depressive disorder (MDD). In this context the functional connectivity of orbitofrontal cortex (OFC) other areas affect regulation circuit interest. The aim study was neural changes during antidepressant treatment and correlates associated with outcome. an exploratory analysis it investigated whether measures moderated response mirtazapine venlafaxine. Twenty-three drug-free patients MDD were recruited from Department...
A defining pathophysiological hallmark of Alzheimer's disease (AD) is the amyloid plaque; an extracellular deposit aggregated fibrillar Aβ
Neuroinflammation plays a key role in neuronal injury after ischemic stroke. PET imaging of translocator protein 18 kDa (TSPO) permits longitudinal, noninvasive visualization neuroinflammation both preclinical and clinical settings. Many TSPO tracers have been developed, however, it is unclear which tracer the most sensitive accurate for monitoring vivo spatiotemporal dynamics across applications. Hence, there need head-to-head comparisons promising different disease states. Accordingly, aim...
Abstract Complex regional pain syndrome (CRPS) is a severely disabling disease characterized by pain, temperature changes, motor dysfunction, and edema that most often occurs as an atypical response to minor surgery or fracture. Inflammation involving activation recruitment of innate immune cells, including both peripheral central myeloid cells (ie, macrophages microglia, respectively), key feature CRPS. However, the exact role time course these cellular processes relative known acute...
Parkinson's disease (PD) is associated with aberrant innate immune responses, including microglial activation and infiltration of peripheral myeloid cells into the central nervous system (CNS). Methods to investigate in PD are limited have not yet elucidated key interactions between neuroinflammation inflammation. Translocator protein 18 kDa (TSPO)-positron emission tomography (PET) a widely evaluated imaging approach for studying activated microglia lineage vivo, however it be fully...
Abstract There is increasing evidence linking neuroinflammation to many neurological disorders including Alzheimer's disease ( AD ); however, its exact contribution manifestation and/or progression poorly understood. Therefore, there a need investigate in both health and disease. Here, we cognitive decline, neuroinflammatory other pathophysiological changes the APP swe × PS 1 Δe9 transgenic mouse model of . Transgenic TG ) mice were compared C57 BL /6 wild type WT at 6, 12 18 months age....
Abstract Purpose: Immunotherapy is a promising approach for many oncological malignancies, including glioblastoma, however, there are currently no available tools or biomarkers to accurately assess whole-body immune responses in patients with glioblastoma treated immunotherapy. Here, the utility of OX40, costimulatory molecule mainly expressed on activated effector T cells known play an important role eliminating cancer cells, was evaluated as PET imaging biomarker quantify and track...
Neuroinflammation is central to the pathological cascade following ischemic stroke. Non-invasive molecular imaging methods have potential provide critical insights into temporal dynamics and role of certain neuroimmune interactions in Specifically, Positron Emission Tomography (PET) translocator protein 18 kDa (TSPO), a marker activated microglia peripheral myeloid-lineage cells, provides means detect track neuroinflammation vivo. Here, we present method accurately quantify using...
Acidosis is a key driver for many diseases, including cancer, sepsis, and stroke. The spatiotemporal dynamics of dysregulated pH across disease remain elusive, current diagnostic strategies do not provide localization alterations. We sought to explore if PET imaging using hydrophobic cyclic peptides that partition into the cellular membrane at low extracellular (denoted as [low] insertion cycles, or pHLIC) can permit accurate in vivo visualization acidosis. <b>Methods:</b> Acid-sensitive...
Abstract Background B cells play a central role in multiple sclerosis (MS) through production of injurious antibodies, secretion pro-inflammatory cytokines, and antigen presentation. The therapeutic success monoclonal antibodies (mAbs) targeting some but not all individuals suffering from MS highlights the need for method to stratify patients monitor response treatments real-time. Herein, we describe development first CD19 positron emission tomography (PET) tracer, its evaluation rodent...
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS) that causes substantial morbidity and diminished quality life. Evidence highlights role myeloid lineage cells in initiation progression MS. However, existing imaging strategies for detecting CNS cannot distinguish between beneficial harmful immune responses. Thus, specifically identify their activation states are critical MS staging monitoring therapeutic We hypothesized positron emission...
In the brain, REST (Repressor Element‐1 Silencing Transcription factor) is a key regulator of neuron cell‐specific gene expression. Nuclear translocation neuronal has been shown to be neuroprotective in healthy ageing context. contrast, inability upregulate nuclear thought leave neurons vulnerable neurodegenerative stimuli, such as Alzheimer’s disease (AD) pathology. Hippocampal and cortical are known particularly susceptible AD‐associated neurodegeneration. However, expression not...
SUMMARY Human genetics implicate defective myeloid responses in the development of late onset, age-associated Alzheimer’s disease (AD). Aging is characterized by a decline metabolism that triggers maladaptive, neurotoxic immune responses. TREM1 an amplifier pro-inflammatory responses, and here we find Trem1 deficiency prevents age-dependent changes metabolism, inflammation, hippocampal memory function. rescues declines ribose-5P, glycolytic intermediate precursor for purine, pyrimidine, NAD...
Abstract Background: B cells play a central role in multiple sclerosis (MS) through production of injurious antibodies, secretion pro-inflammatory cytokines, and antigen presentation. The therapeutic success monoclonal antibodies (mAbs) targeting some but not all individuals suffering from MS highlights the need for method to stratify patients monitor response treatments real time. Herein, we describe development first CD19 positron emission tomography (PET) tracer its evaluation rodent...