A5092349024- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Inflammation biomarkers and pathways
- Kawasaki Disease and Coronary Complications
- Alzheimer's disease research and treatments
Stanford University
2023-2024
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer's disease (AD), with recent proteomic studies highlighting disrupted glial in AD. We report that inhibition indoleamine-2,3-dioxygenase 1 (IDO1), which metabolizes tryptophan to kynurenine (KYN), rescues hippocampal memory function mouse preclinical models AD by restoring astrocyte metabolism. Activation astrocytic IDO1 amyloid β and tau oligomers increases KYN suppresses glycolysis an aryl hydrocarbon...
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS) that causes substantial morbidity and diminished quality life. Evidence highlights role myeloid lineage cells in initiation progression MS. However, existing imaging strategies for detecting CNS cannot distinguish between beneficial harmful immune responses. Thus, specifically identify their activation states are critical MS staging monitoring therapeutic We hypothesized positron emission...