A5093489118- Neuroinflammation and Neurodegeneration Mechanisms
- Machine Learning in Bioinformatics
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
Stanford University
2023-2024
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer's disease (AD), with recent proteomic studies highlighting disrupted glial in AD. We report that inhibition indoleamine-2,3-dioxygenase 1 (IDO1), which metabolizes tryptophan to kynurenine (KYN), rescues hippocampal memory function mouse preclinical models AD by restoring astrocyte metabolism. Activation astrocytic IDO1 amyloid β and tau oligomers increases KYN suppresses glycolysis an aryl hydrocarbon...
Dementia is a complex neurological disorder characterized by progressive decline in cognitive functions. Recent studies have suggested link between neuroinflammation and the development of dementia, particularly Alzheimer's disease. This study focuses on analysis inflammatory gene expression patterns parietal cortex (PCx) temporal (TCx) from human brain RNA sequence data set, aiming to derive insights into underlying genetic associated with as well prediction dementia. Using five machine...