A5088022885- Chemical Synthesis and Analysis
- Microbial Natural Products and Biosynthesis
- Alzheimer's disease research and treatments
- Neuropeptides and Animal Physiology
- Mitochondrial Function and Pathology
- Single-cell and spatial transcriptomics
- Enzyme Structure and Function
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics and Chromatin Dynamics
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
Salk Institute for Biological Studies
2023-2024
Haverford College
2021-2022
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer's disease (AD), with recent proteomic studies highlighting disrupted glial in AD. We report that inhibition indoleamine-2,3-dioxygenase 1 (IDO1), which metabolizes tryptophan to kynurenine (KYN), rescues hippocampal memory function mouse preclinical models AD by restoring astrocyte metabolism. Activation astrocytic IDO1 amyloid β and tau oligomers increases KYN suppresses glycolysis an aryl hydrocarbon...
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer Disease (AD), and recent proteomic studies highlight disruption glial carbohydrate with disease progression. Here, we report that inhibition indoleamine-2,3-dioxygenase 1 (IDO1), which metabolizes tryptophan to kynurenine (KYN) in the first step pathway, rescues hippocampal memory function plasticity preclinical models amyloid tau pathology by restoring astrocytic metabolic support neurons. Activation IDO1 astrocytes...
Schizophrenia (SZ) is a serious mental illness and neuropsychiatric brain disorder with behavioral symptoms that include hallucinations, delusions, disorganized behavior, cognitive impairment. Regulation of such behaviors requires utilization neurotransmitters released to mediate cell-cell communication which are essential functions in health disease. We hypothesized SZ may involve dysregulation secreted from neurons. To gain an understanding human SZ, induced neurons (iNs) were derived...
ABSTRACT Late-onset Alzheimer’s disease (LOAD) is typically sporadic, correlated only to advanced age, and has no clear genetic risk factors. The sporadic nature of LOAD presents a challenge understanding its pathogenesis mechanisms. Here, we comprehensively investigated the epigenome primary entorhinal cortex brain tissues via single-cell multi-omics technologies, simultaneously capturing DNA methylation 3D chromatin conformation. We identified AD-specific signatures found they interact...
The strategic redesign of microbial biosynthetic pathways is a compelling route to access molecules diverse structure and function in potentially environmentally sustainable fashion. promise this approach hinges on an improved understanding acyl carrier proteins (ACPs), which serve as central hubs pathways. These small, flexible mediate the transport molecular building blocks intermediates enzymatic partners that extend tailor growing natural products. Past combinatorial biosynthesis efforts...
Abstract The strategic redesign of microbial biosynthetic pathways is a compelling route to access molecules diverse structure and function in potentially environmentally sustainable fashion. promise this approach hinges on an improved understanding acyl carrier proteins (ACPs), which serve as central hubs pathways. These small, flexible mediate the transport molecular building blocks intermediates enzymatic partners that extend tailor growing natural products. Past combinatorial...