Jeff Metcalf
A5025870424- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- HIV Research and Treatment
- Higher Education Governance and Development
- Dementia and Cognitive Impairment Research
- Higher Education Research Studies
- Genetics and Neurodevelopmental Disorders
- Intergenerational Family Dynamics and Caregiving
- Neurological diseases and metabolism
- Lipoproteins and Cardiovascular Health
- Parkinson's Disease Mechanisms and Treatments
- Advanced Fluorescence Microscopy Techniques
- Autophagy in Disease and Therapy
- Neonatal and fetal brain pathology
- Management and Marketing Education
- Genomics and Chromatin Dynamics
- HER2/EGFR in Cancer Research
- Single-cell and spatial transcriptomics
- Medical Imaging and Analysis
- Protein Hydrolysis and Bioactive Peptides
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Structural Engineering and Vibration Analysis
- Underground infrastructure and sustainability
University of California, San Diego
2015-2023
VA San Diego Healthcare System
2021
The University of Texas at Arlington
2017
Kentucky Christian University
2003
University of Cambridge
1995
Age-related cognitive impairment is multifactorial, with numerous underlying and frequently co-morbid pathological correlates. Amyloid beta (Aβ) plays a major role in Alzheimer's type age-related impairment, addition to other etiopathologies such as Aβ-independent hyperphosphorylated tau, cerebrovascular disease, myelin damage, which also warrant further investigation. Classical methods, even the setting of gold standard postmortem brain assessment, involve semi-quantitative ordinal staging...
Abstract Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive mild head impacts characterized by perivascular hyperphosphorylated tau (p-tau) in neurofibrillary tangles (NFTs) and neurites the depths of neocortical sulci. In moderate to advanced CTE, NFTs accumulate hippocampus, potentially overlapping neuroanatomically primary age-related (PART), an Alzheimer disease-like pathology hippocampus devoid amyloid plaques. We measured p-tau burden using positive-pixel...
Abstract Insulin and its receptor are widely expressed in a variety of tissues throughout the body including liver, adipose tissue, liver brain. The insulin is as two functionally distinct isoforms, differentiated by single 12 amino acid exon. designated IR/A IR/B, highly tissue cell specific manner relative proportions different isoforms vary during development, aging disease states. high degree similarity between has prevented detailed studies differentiation traditional immunological...
In response to the growing demand for power and energy across US world-wide, development of efficient solutions has become very important. Considering data center applications, cooling consumption constitutes a significant part overall usage system. process optimizing consumed per performance unit, liquid one key solutions. Liquid addresses critical issues related typical air in servers because its better heat transfer characteristics. Water-cooling at device level can be an solution since...
ABSTRACT Late-onset Alzheimer’s disease (LOAD) is typically sporadic, correlated only to advanced age, and has no clear genetic risk factors. The sporadic nature of LOAD presents a challenge understanding its pathogenesis mechanisms. Here, we comprehensively investigated the epigenome primary entorhinal cortex brain tissues via single-cell multi-omics technologies, simultaneously capturing DNA methylation 3D chromatin conformation. We identified AD-specific signatures found they interact...
This study examined faculty and administrator perspectives on the importance of institutional effectiveness activities in two-year colleges. The compared attitudes measured impact four predictor variables. article closes with a discussion strategies that institutions may adopt to cultivate administrative support for initiatives.
Inflammation is a major component of Alzheimer's disease (AD) pathology, contributing with amyloid deposition, dementia and cognitive impairment. Epigenetic mechanisms are implicated in neurodegeneration: AD brains have acceleration age-related methylation changes genes associated increased susceptibility differentially methylated AD. We reported before that the innate immune response inflammation show altered DNA brains. Moreover, we observed inhibition enzymes activates microglia,...
Abstract Primary age-related tauopathy (PART) is a neurodegenerative with features distinct from but also overlapping Alzheimer disease (AD). While both exhibit Alzheimer-type temporal lobe neurofibrillary degeneration alongside amnestic cognitive impairment, PART develops independently of amyloid-β (Aβ) deposition in plaques. The pathogenesis unknown, evidence suggests it associated genes that promote tau pathology as well others protect Aβ toxicity. Here, we performed genetic association...
Conference Abstract| July 01 1995 Apolipoprotein (a) and a Novel Homologue are Expressed in Human Tumours CD Byrne; Byrne 1Dept of Clinical Biochemistry, Cambridge University, UK Search for other works by this author on: This Site PubMed Google Scholar K Schwartz; Schwartz 2Falk CVRC Stanford CA, USA P Kemp; Kemp 3 Dept D Grainger; Grainger J Metcalf; Metcalf RM Lawn Clin Sci (Lond) (1995) 89 (s33): 40P. https://doi.org/10.1042/cs089040Pb Views Icon Article contents Figures & tables Video...