A5053794069- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Imaging and Analysis
- Dementia and Cognitive Impairment Research
- AI in cancer detection
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetic Mapping and Diversity in Plants and Animals
- Computational Drug Discovery Methods
- Advanced Neuroimaging Techniques and Applications
- Kruppel-like factors research
- Neuroscience and Neuropharmacology Research
- Genetics, Aging, and Longevity in Model Organisms
- Anesthesia and Neurotoxicity Research
- Inflammasome and immune disorders
- Gene Regulatory Network Analysis
- Epigenetics and DNA Methylation
- Bacillus and Francisella bacterial research
- Functional Brain Connectivity Studies
- Machine Learning in Healthcare
- Nuclear Receptors and Signaling
- Tryptophan and brain disorders
- Prenatal Substance Exposure Effects
- Probability and Statistical Research
Region of Southern Denmark
2025
Odense University Hospital
2025
Bryan College
2025
Icahn School of Medicine at Mount Sinai
2013-2023
Allen Institute for Brain Science
2022-2023
Sarah Cannon
2019
Mount Sinai Hospital
2014
National Institute of Allergy and Infectious Diseases
2014
National Institutes of Health
2012-2013
Elucidating brain cell type specific gene expression patterns is critical towards a better understanding of how cell-cell communications may influence functions and dysfunctions. We set out to compare contrast five human murine type-specific transcriptome-wide RNA data sets that were generated within the past several years. defined three measures type-relative including specificity, enrichment, absolute identified corresponding consensus "signatures," which well conserved across sets....
Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration. However, despite extensive clinical genomic studies, molecular basis AD development progression remains elusive. To elucidate systems associated with AD, we developed a large scale gene expression dataset from 1053 postmortem brain samples across 19 cortical regions 125 individuals severity spectrum dementia neuropathology AD. We excluded specimens that...
Dissecting the regulatory relationships between genes is a critical step towards building accurate predictive models of biological systems. A powerful approach this end to systematically study differences in correlation gene pairs more than one distinct condition. In we develop an R package, DGCA (for Differential Gene Correlation Analysis), which offers suite tools for computing and analyzing differential correlations across multiple conditions. To minimize parametric assumptions, computes...
Oligodendrocytes (OLs) and myelin are critical for normal brain function have been implicated in neurodegeneration. Several lines of evidence including neuroimaging neuropathological data suggest that Alzheimer's disease (AD) may be associated with dysmyelination a breakdown OL-axon communication. In order to understand this phenomenon on molecular level, we systematically interrogated OL-enriched gene networks constructed from large-scale genomic, transcriptomic proteomic obtained human AD...
Signals of danger and damage in the cytosol cells are sensed by NOD-like receptors (NLRs), which components multiprotein complexes called inflammasomes. Inflammasomes activate caspase-1, resulting IL-1-beta IL-18 secretion an inflammatory response. To date, only known activator rodent Nlrp1 is anthrax lethal toxin (LT), a protease secreted bacterial pathogen Bacillus anthracis. Although susceptibility mouse macrophages to LT has been genetically linked Nlrp1b, mice harbor two additional...
Abstract Tauopathies are a category of neurodegenerative diseases characterized by the presence abnormal tau protein-containing neurofibrillary tangles (NFTs). NFTs universally observed in aging, occurring with or without concomitant accumulation amyloid-beta peptide (Aβ) plaques that typifies Alzheimer disease (AD), most common tauopathy. Primary age-related tauopathy (PART) is an Aβ-independent process affects medial temporal lobe both cognitively normal and impaired subjects. Determinants...
Brain cell structure is a key determinant of neural function that frequently altered in neurobiological disorders. Following the global loss blood flow to brain initiates postmortem interval (PMI), cells rapidly become depleted energy and begin decompose. To ensure our methods for studying using autopsy tissue are robust reproducible, there critical need delineate expected changes morphometry during PMI. We searched multiple databases identify studies measuring effects PMI on (i.e. external...
Age-related cognitive impairment is multifactorial, with numerous underlying and frequently co-morbid pathological correlates. Amyloid beta (Aβ) plays a major role in Alzheimer's type age-related impairment, addition to other etiopathologies such as Aβ-independent hyperphosphorylated tau, cerebrovascular disease, myelin damage, which also warrant further investigation. Classical methods, even the setting of gold standard postmortem brain assessment, involve semi-quantitative ordinal staging...
Alzheimer's disease (AD) and primary age-related tauopathy (PART) both harbor 3R/4R hyperphosphorylated-tau (p-tau)-positive neurofibrillary tangles (NFTs) but differ in the spatial p-tau development hippocampus.
Immersing the brain in a solution containing formaldehyde is commonly used method for preserving structure of human tissue banking. However, there are questions about quality preservation using this method, as takes relatively long period time to penetrate large organ such brain. As result, critical need determine whether immersion fixation an adequate initial method. To address this, we present exploratory histologic findings from our bank following hemi-sectioned specimens under...
The purpose of this study was to clarify the potentially life-saving critical interventions performed on children below age seven by physician-manned mobile emergency care unit (MECU) in Odense, Denmark. We investigated relation morbidity and mortality. A retrospective cohort all MECU missions involving seven. period from October 1 2007 December 31 2020. Data sources were Odense database, Danish National Patient Registry, Civil Registration System. Variables interventions, severity...
When faced with the prospect of death, some people would prefer a form long-term preservation that may allow them to be restored healthy life in future, if technology ever develops point this is feasible and humane. Some believe we have capacity perform type experimental today-although it has never been proven-using contemporary methods preserve structure brain. The idea morphomolecular organization brain encodes information required for psychological properties such as personality memories....
Recent studies have indicated that innate immune signalling molecules are involved in late-onset Alzheimer's disease (LOAD) risk. Amyloid beta (Aβ) accumulates AD brain, and has been proposed to act as a trigger of responses. Caspase-4 is an important part the response. We recently characterized transgenic mice carrying human CASP4, observed manifested profound responses lipopolysaccharide (LPS). Since these inflammatory processes aetiology AD, we now analysed correlation expression...
Fluid preservation is nearly universally used in brain banking to store fixed tissue specimens for future research applications. However, the effects of long-term immersion on neural circuitry and biomolecules are not well characterized. As a result, there need synthesize studies investigating fluid tissue. We searched PubMed other databases identify measuring nervous system categorized based preservative used: formaldehyde solutions, buffer alcohol storage after clearing, cryoprotectant...
Aging-related cognitive decline is associated with brain structural changes and synaptic loss. However, the molecular mechanisms of during normal aging remain elusive.Using GTEx transcriptomic data from 13 regions, we identified aging-associated alterations cell-type compositions in males females. We further constructed gene co-expression networks modules key regulators shared by both sexes or specific to A few regions such as hippocampus hypothalamus show vulnerability males, while...
Abstract Background Upon infection of a mammalian host, Bacillus anthracis responds to host cues, and particularly elevated temperature (37°C) bicarbonate/CO 2 concentrations, with increased expression virulence factors that include the anthrax toxins extracellular capsular layer. This response requires presence pXO1 plasmid-encoded pleiotropic regulator AtxA. To better understand genetic basis this response, we utilized controlled in vitro system Next Generation sequencing determine compare...
Abstract Understanding age acceleration, the discordance between biological and chronological age, in brain can reveal mechanistic insights into normal physiology as well elucidate pathological determinants of age-related functional decline identify early disease changes context Alzheimer’s other disorders. Histopathological whole slide images provide a wealth pathologic data on cellular level that be leveraged to build deep learning models assess acceleration. Here, we used collection...