A5062955581- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- Neurological diseases and metabolism
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- Traumatic Brain Injury Research
- Balance, Gait, and Falls Prevention
- Dementia and Cognitive Impairment Research
- Biotin and Related Studies
- S100 Proteins and Annexins
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- Diet and metabolism studies
- Forensic Entomology and Diptera Studies
- Cell Image Analysis Techniques
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Cerebral Palsy and Movement Disorders
Icahn School of Medicine at Mount Sinai
2023-2024
Allen Institute for Brain Science
2023-2024
University Memory and Aging Center
2021
University of California, San Francisco
2021
Brain cell structure is a key determinant of neural function that frequently altered in neurobiological disorders. Following the global loss blood flow to brain initiates postmortem interval (PMI), cells rapidly become depleted energy and begin decompose. To ensure our methods for studying using autopsy tissue are robust reproducible, there critical need delineate expected changes morphometry during PMI. We searched multiple databases identify studies measuring effects PMI on (i.e. external...
Abstract Progressive supranuclear palsy (PSP) is a rare Parkinsonian disorder characterized by problems with movement, balance, cognition, and other symptoms. PSP differs from Alzheimer’s disease (AD) neurodegenerative diseases displaying abnormal forms of the microtubule-associated protein tau (“tauopathies”) presence pathology not only in neurons, but also astrocytes oligodendrocytes. Genetic contributors may mediate these differences, however much genetics remains unexplained. Here we...
ABSTRACT Progressive supranuclear palsy (PSP) is a sporadic neurodegenerative tauopathy variably affecting brainstem and cortical structures characterized by tau inclusions in neurons glia. The precise mechanism whereby these protein aggregates lead to cell death remains unclear. To investigate the contribution of different cellular abnormalities PSP pathogenesis, we performed single-nucleus RNA sequencing analyzed 45,559 high quality nuclei targeting subthalamic nucleus adjacent from human...
Progressive supranuclear palsy (PSP) is a sporadic neurodegenerative tauopathy variably affecting brainstem and cortical structures, characterized by tau inclusions in neurons glia. The precise mechanism whereby these protein aggregates lead to cell death remains unclear. To investigate the contribution of different cellular abnormalities PSP pathogenesis, we performed single-nucleus RNA sequencing (snRNA-seq) analyzed 50,708 high quality nuclei targeting diencephalon, including subthalamic...
Abstract Background The accumulation of abnormal tau protein in neurons and glia the human brain is defining feature neurodegenerative diseases known as tauopathies. Progressive supranuclear palsy (PSP), most common primary tauopathy, typified by selective vulnerability dopaminergic midbrain leading to an atypical parkinsonian movement disorder. To investigate candidate disease mechanisms underlying PSP, there a critical need for model systems that more accurately recapitulate cellular...
Neurodegenerative disease syndromes often affect personality and interpersonal behavior in addition to cognition, but there are few structured observational measures of altered social demeanor validated for this population. We developed the Social Behavior Observer Checklist (SBOCL), a 3-min checklist tool, facilitate identification patterns that diagnostically relevant different neurodegenerative syndromes. Research assistants without formal clinical training dementia used SBOCL describe...
Abstract Background Progressive supranuclear palsy (PSP) is the most common primary tauopathy, with a constellation of pathological features including 4R‐tau positive neurofibrillary tangles and tufted astrocytes. Most PSP cases are sporadic associated structural variation in 17q21.31 MAPT locus as well other loci, EIF2AK3 which critical for integrated stress response (ISR). Despite these known genetic risk associations, mechanisms underlying disease pathogenesis unclear. To investigate...
Abstract Background Progressive supranuclear palsy (PSP) is the most common primary tauopathy, with a constellation of pathological features including 4R‐tau positive neurofibrillary tangles and tufted astrocytes. Most PSP cases are sporadic associated structural variation in 17q21.31 MAPT locus as well other risk loci, EIF2AK3 which critical for unfolded protein response (UPR). Despite these known genetic associations, mechanisms underlying disease pathogenesis unclear. To investigate...