A5101922943- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Parkinson's Disease Mechanisms and Treatments
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Memory and Neural Mechanisms
- Diet and metabolism studies
- Obstructive Sleep Apnea Research
- Computational Drug Discovery Methods
- Barrier Structure and Function Studies
- Neurological Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Endoplasmic Reticulum Stress and Disease
- Dementia and Cognitive Impairment Research
- Multiple Sclerosis Research Studies
- Sleep and related disorders
- S100 Proteins and Annexins
- Health Systems, Economic Evaluations, Quality of Life
- Autophagy in Disease and Therapy
- Nerve Injury and Rehabilitation
State University of Norte Fluminense
2025
Icahn School of Medicine at Mount Sinai
2018-2024
Allen Institute for Brain Science
2019-2024
Rockefeller University
2014-2021
Universidade do Porto
2017
Charing Cross Hospital
2002
Significance Aging is often accompanied by cognitive decline. It of critical importance to understand the synaptic susceptibilities glutamatergic neural circuits age-related decline and intervene in this process. Maintenance health face aging a crucially important therapeutic goal. We show that glutamate modulator, riluzole, prevents memory loss induces clustering dendritic spines. Clustering element plasticity has been previously demonstrated increase strength. This study further elucidates...
Dysregulation of glutamatergic neural circuits has been implicated in a cycle toxicity, believed among the neurobiological underpinning Alzheimer's disease. Previously, we reported preclinical evidence that glutamate modulator riluzole, which is FDA approved for treatment amyotrophic lateral sclerosis, potential benefits on cognition, structural and molecular markers ageing The objective this study was to evaluate pilot clinical trial, using neuroimaging biomarkers, efficacy safety riluzole...
Tau protein aggregates are a major driver of neurodegeneration and behavioral impairments in tauopathies, including Alzheimer's disease (AD). Apolipoprotein E4 (
Significance The excitatory amino acid transporter 2 (EAAT2) is the predominant glutamate in mammalian brain, and its expression reduced aging sporadic Alzheimer’s disease (AD) brains. mechanisms through which EAAT2 contributes to cognitive decline AD-related neurodegeneration differential functional roles of astrocytic neuronal components remain largely unknown. This study uses behavioral analysis show that deficiency mice causes age-dependent dysfunction. Furthermore, we gene from human AD...
Optimal functioning of neuronal networks is critical to the complex cognitive processes memory and executive function that deteriorate in Alzheimer's disease (AD). Here we use cellular animal models as well human biospecimens show AD-related stressors mediate global disturbances dynamic intra- inter-neuronal through pathologic rewiring chaperome system into epichaperomes. These structures provide backbone upon which proteome-wide connectivity, turn, protein become disturbed ultimately...
Abstract Alzheimer’s disease (AD) represents a major healthcare burden with no effective treatment. The glutamate modulator, riluzole, was shown to reverse many AD-related gene expression changes and improve cognition in aged rats. However, riluzole’s effect on amyloid beta (Aβ) pathology, histopathological hallmark of AD, remains unclear. 5XFAD transgenic mice, which harbor β precursor protein (APP) presenilin mutations exhibit early Aβ accumulation, were treated riluzole from 1 6 months...
Abstract Pathological tau proteins in patients with Alzheimer's disease (AD) mainly accumulate the form of neurofibrillary tangles (NFTs) and neuritic plaques (NPs). However, molecular properties species present NFTs NPs are not known. We tested hypothesis that within NFT‐predominant tissue (NFT_AD) distinct more toxic than those NP‐predominant (NP_AD). analyzed from post mortem prefrontal cortical brains NFT_AD NP_AD. Compared to NP_AD, displayed highly phosphorylated oligomers, possessed...
ABSTRACT Progressive supranuclear palsy (PSP) is a sporadic neurodegenerative tauopathy variably affecting brainstem and cortical structures characterized by tau inclusions in neurons glia. The precise mechanism whereby these protein aggregates lead to cell death remains unclear. To investigate the contribution of different cellular abnormalities PSP pathogenesis, we performed single-nucleus RNA sequencing analyzed 45,559 high quality nuclei targeting subthalamic nucleus adjacent from human...
Progressive supranuclear palsy (PSP) is a sporadic neurodegenerative tauopathy variably affecting brainstem and cortical structures, characterized by tau inclusions in neurons glia. The precise mechanism whereby these protein aggregates lead to cell death remains unclear. To investigate the contribution of different cellular abnormalities PSP pathogenesis, we performed single-nucleus RNA sequencing (snRNA-seq) analyzed 50,708 high quality nuclei targeting diencephalon, including subthalamic...
Coracoid transfer procedures are known to be successful when it comes prevention of recurrence. However, all them invariably associated with high complication rates, especially limited range motion.Arthroscopic technique was found have an overall lower rate complications compared the open procedures.Despite being scarce, CHSJ data roughly overlap literature.Different surgical been described for treatment recurrent anterior dislocation shoulder. Despite documented success procedures, some...
Abstract Progressive supranuclear palsy (PSP) is a neurodegenerative disorder whose molecular complexity at single cell level has not been evaluated. Here we analyzed 45,559 high quality nuclei from the subthalamic nucleus and associated basal ganglia regions post-mortem human PSP brains with varying degrees of tau pathology compared to controls ( n =3 per group). We identified novel astrocyte-oligodendrocyte hybrid populations that overexpress neurotropic factors in conjunction suppression...
Abstract Background Heterogeneity in the progression of clinical dementia poses a significant challenge, impeding effectiveness current therapies for Alzheimer’s disease (AD). To decipher molecular mechanisms governing heterogeneity AD that remains critical knowledge gap precluding rational therapeutic design, we investigated biochemical and biophysical properties tau present inferior temporal gyrus (ITG) prefrontal cortex (PFC) brain regions patients who had varying rates. explore gene...
Abstract Background Progressive supranuclear palsy (PSP) is the most common primary tauopathy, with a constellation of pathological features including 4R‐tau positive neurofibrillary tangles and tufted astrocytes. Most PSP cases are sporadic associated structural variation in 17q21.31 MAPT locus as well other loci, EIF2AK3 which critical for integrated stress response (ISR). Despite these known genetic risk associations, mechanisms underlying disease pathogenesis unclear. To investigate...