A5004282023- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Ion Channels and Receptors
- Vestibular and auditory disorders
- Molecular Biology Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Motor Control and Adaptation
- Visual perception and processing mechanisms
Baylor University
2018-2024
Allen Institute for Brain Science
2024
Icahn School of Medicine at Mount Sinai
2024
University of Waterloo
2010
Abstract Cochlear outer hair cells (OHCs) are responsible for the exquisite frequency selectivity and sensitivity of mammalian hearing. During development, maturation OHC afferent connectivity is refined by coordinated spontaneous Ca 2+ activity in both sensory non‐sensory cells. Calcium signalling neonatal OHCs can be modulated oncomodulin (OCM, β‐parvalbumin), an EF‐hand calcium‐binding protein. Here, we investigated whether OCM regulates during development. Using a genetically encoded...
In cochlear outer hair cells (OHCs), a network of Ca2+ channels, pumps and Ca2+-binding proteins (CaBPs) regulates the localization, spread, magnitude free ions. During early postnatal development, OHCs express three prominent mobile EF-hand CaBPs: oncomodulin (OCM), α-parvalbumin (APV) sorcin. We have previously shown that deletion Ocm (Ocm-/-) gives rise to progressive dysfunction in young adult mice. Here, we show changes signaling begin development Ocm-/- While mutant exhibit normal...
Abstract Tight regulation of Ca 2+ is crucial for the function cochlear outer hair cells (OHCs). Dysregulation homeostasis in OHCs associated with impaired hearing and contributes to increased vulnerability environmental insults, such as noise exposure. signaling developing can be modulated by oncomodulin (OCM), an EF-hand calcium-binding protein. Here, we investigated whether lack OCM disrupts control intracellular mature OHCs, influences noise. Using young adult CBA/CaJ mice, found that...
The differential regulation of COX17, COX19 and COX23 mRNAs by the nonsense-mediated mRNA decay (NMD) pathway was investigated. NMD regulates that aberrantly terminate translation. This includes harboring premature translation termination codons natural mRNAs. Most regulated encode fully functional proteins involved in various cellular processes. However, cause targeting most these is not understood. Analysis a set copper homeostasis showed subset function mitochondrial homeostasis. Here, we...
Ca2+ signaling is a major contributor to sensory hair cell function in the cochlea. Oncomodulin (OCM) binding protein (CaBP) preferentially expressed outer cells (OHCs) of cochlea and few other specialized types. Here, we expand on our previous reports show that OCM delays hearing loss mice two different genetic backgrounds: CBA/CaJ C57Bl/6J. In both backgrounds, disruption Ocm leads early progressive as measured by auditory brainstem response (ABR) distortion product otoacoustic emission...
Cochlear outer hair cells (OHCs) play a fundamental role in the hearing sensitivity and frequency selectivity of mammalian are especially vulnerable to noise-induced damage. The OHCs depend on Ca 2+ homeostasis, which is balance between influx extrusion, as well buffering by proteins organelles. Alterations OHC homeostasis not only an immediate response noise, but also associated with impaired auditory function. However, there little known about contribution organelles vulnerability noise....
ABSTRACT Ca 2+ signaling is a major contributor to sensory hair cell function in the cochlea. Oncomodulin (OCM) binding protein preferentially expressed outer cells of cochlea and few other specialized types. Here, we expand on our previous reports show that OCM prevents early progressive hearing loss mice two different genetic backgrounds: CBA/CaJ C57BI/6J. In both backgrounds, disruption Ocm leads as measured by auditory brainstem response (ABR) distortion product otoacoustic emission...
Abstract Cochlear outer hair cells (OHCs) are responsible for the exquisite frequency selectivity and sensitivity of mammalian hearing. During development, maturation OHC afferent connectivity is refined by coordinated spontaneous Ca 2+ activity in both sensory non-sensory cells. Calcium signaling neonatal OHCs can be modulated Oncomodulin (OCM, β-parvalbumin), an EF-hand calcium-binding protein. Here, we investigated whether OCM regulates during development. Using a genetically encoded...
Patients with optic ataxia resulting from damage to the posterior parietal cortex display gross pointing deficits targets in peripheral vision. Although performance central vision is better when compared vision, it may be possible detect subtle movement kinematics. We analyzed visually guided movements patient ME, who suffered a right superior lesion leading ataxia. ME and group of elderly controls made both hands that varied size on trial-to-trial basis (i.e., speed-accuracy trade-off...
Abstract In cochlear outer hair cells (OHCs), a network of Ca 2+ channels, pumps and -binding proteins (CaBPs) regulates the localization, spread, magnitude free ions. During early postnatal development, OHCs express three prominent mobile EF-hand CaBPs: oncomodulin (OCM), α-parvalbumin (APV) sorcin. We have previously shown that deletion Ocm ( -/- ) gives rise to progressive dysfunction in young adult mice. Here, we show changes signaling begin development While mutant exhibit normal...