A5022605809- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Genetic Associations and Epidemiology
- Advanced Neuroimaging Techniques and Applications
- Bioinformatics and Genomic Networks
- Cerebrovascular and genetic disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Amyotrophic Lateral Sclerosis Research
- Acute Ischemic Stroke Management
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disorders and Treatments
- Frailty in Older Adults
- Genetics and Neurodevelopmental Disorders
- Folate and B Vitamins Research
- Neurological diseases and metabolism
- Tryptophan and brain disorders
- Nuclear Receptors and Signaling
Rush University Medical Center
2016-2025
Rush University
2016-2025
University of Illinois Chicago
2012-2024
Harvard University
2008-2024
Illinois Institute of Technology
2019-2024
Pacific Northwest National Laboratory
2022-2024
Indiana University – Purdue University Indianapolis
2024
Indiana University School of Medicine
2024
Western University
2018-2024
The Memory Clinic
2024
Abstract A consensus panel from the United States and Europe was convened recently to update revise 1997 guidelines for neuropathologic evaluation of Alzheimer's disease (AD) other diseases brain that are common in elderly. The new recognize pre‐clinical stage AD, enhance assessment AD include amyloid accumulation as well neurofibrillary change neuritic plaques, establish protocols Lewy body disease, vascular injury, hippocampal sclerosis, TDP‐43 inclusions, recommend standard approaches...
To examine the spectrum of neuropathology in persons from Rush Memory and Aging Project, a longitudinal community-based clinical-pathologic cohort study.The study includes older who agreed to annual clinical evaluation brain donation. We examined neuropathologic diagnoses, including Alzheimer disease (AD) (NIA-Reagan Criteria), cerebral infarctions, Parkinson disease/Lewy body (PD/LBD), first 141 autopsies. calculated frequency each diagnosis alone mixed diagnoses. used logistic regression...
While a potential causal factor in Alzheimer’s disease (AD), brain insulin resistance has not been demonstrated directly that disorder. We provide such demonstration here by showing the hippocampal formation (HF) and, to lesser degree, cerebellar cortex AD cases without diabetes exhibit markedly reduced responses signaling IR→IRS-1→PI3K pathway with greatly IGF-1 IGF-1R→IRS-2→PI3K pathway. Reduced were maximal at level of IRS-1 and consistently associated basal elevations phosphorylated...
To examine the relation of National Institute on Aging-Reagan (NIA-Reagan) neuropathologic criteria Alzheimer disease (AD) to level cognitive function in persons without dementia or mild impairment (MCI).More than 2,000 participating Religious Orders Study Memory and Aging Project agreed annual detailed clinical evaluation brain donation. The studies had 19 neuropsychological performance tests common that assessed five domains, including episodic memory, semantic working perceptual speed,...
Social isolation in old age has been associated with risk of developing dementia, but the perceived isolation, or loneliness, is not well understood.To test hypothesis that loneliness increased Alzheimer disease (AD).Longitudinal clinicopathologic cohort study up to 4 years annual in-home follow-up.A total 823 older persons free dementia at enrollment were recruited from senior citizen facilities and around Chicago, Ill. Loneliness was assessed a 5-item scale baseline (mean +/- SD, 2.3 0.6)...
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by stereotypical proteinopathy in older adults, with or without coexisting hippocampal sclerosis pathology. LATE-NC common proteinopathy, associated an amnestic dementia syndrome that mimicked Alzheimer's-type retrospective autopsy studies. distinguished from frontotemporal lobar degeneration pathology based on its epidemiology...
<h3>Background</h3> Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type fat protects against Alzheimer disease. <h3>Objective</h3> To examine fish consumption and intake different types protect <h3>Design</h3> Prospective conducted from 1993 through 2000, a stratified random sample geographically defined community. Participants were followed up for an average 3.9 years the development <h3>Patients</h3> A total...
<b><i><i>Background:</i></i></b> Cognitive abilities of older persons range from normal, to mild cognitive impairment, dementia. Few large longitudinal studies have compared the natural history impairment with similar without impairment. <b><i><i>Methods:</i></i></b> Participants were Catholic clergy dementia, 211 and 587 who underwent annual clinical evaluation for AD an assessment different abilities. performance tests summarized yield a composite measure global function separate summary...
Mixed pathologies are common in older persons with dementia. Little is known about mixed probable Alzheimer disease (AD) and the spectrum of neuropathology mild cognitive impairment (MCI). The objective this study was to investigate single age-related neuropathologies AD MCI.The included 483 autopsied participants from Religious Orders Study Rush Memory Aging Project (National Institute Neurological Communicative Disorders Stroke-Alzheimer's Disease Related Association criteria), MCI...
The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort study of common chronic conditions aging with an emphasis on decline in cognitive motor function risk Alzheimer’s disease (AD). In this manuscript, we first summarize the design methods. Then, present data on: 1) relation to cognition, disability, death; 2) factors outcomes, disability 3) neuropathologic indices outcomes; 4) indices; 5) additional findings. findings are discussed contextualized....
The authors examined change in cognitive abilities older Catholic clergy members. For up to 6 years, participants underwent annual clinical evaluations, which included a battery of tests from summary measures 7 were derived. On average, decline occurred each ability and was more rapid persons than younger persons. However, wide individual differences evident at all ages. Rate given domain not strongly related baseline level function that but moderately associated with rates other domains....
The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer’s disease (AD). In this manuscript, we summarize the methods including design describe clinical evaluation, assessment risk factors, collection ante-mortem biological specimens, brain autopsy selected postmortem data. results: 1) review relation neuropathologic indices to diagnoses cognition proximate death; 2) examine factors outcomes; 3) measures neuropathology; 4) additional findings. We...
Abstract Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging–Alzheimer's Association describes biomarker‐based pathologic definition of focused amyloid, tau, neuronal injury. In response this article, here we first discussed that dysfunction is an important early event in...