Charles L. White
A5024767343- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Glioma Diagnosis and Treatment
- Ruminant Nutrition and Digestive Physiology
- Genomics and Rare Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Prion Diseases and Protein Misfolding
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Mitochondrial Function and Pathology
- Neurogenetic and Muscular Disorders Research
- AI in cancer detection
- Trace Elements in Health
- Cellular transport and secretion
- Genetic and phenotypic traits in livestock
- Genetics and Neurodevelopmental Disorders
- Machine Learning in Healthcare
- Botanical Research and Chemistry
- Animal Nutrition and Physiology
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2001-2024
University of Rochester Medical Center
2024
Icahn School of Medicine at Mount Sinai
2020-2022
Mayo Clinic in Florida
2010-2020
Banner Sun Health Research Institute
2020
Mayo Clinic in Arizona
2020
Indiana University – Purdue University Indianapolis
2020
St. Michael's Hospital
2020
University of Iowa
2020
Interleukin 1, an immune response-generated cytokine that stimulates astrocyte proliferation and reactivity (astrogliosis), was present in up to 30 times as many glial cells tissue sections of brain from patients with Down syndrome Alzheimer disease compared age-matched control subjects. Most interleukin 1-immunoreactive glia were classified microglia. The number 1 immunoreactive neurons did not appear differ brain. Numerous temporal lobe astrocytes postnatal intensely 1-, S-100-, fibrillary...
We describe a recently recognized disease entity, limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by stereotypical proteinopathy in older adults, with or without coexisting hippocampal sclerosis pathology. LATE-NC common proteinopathy, associated an amnestic dementia syndrome that mimicked Alzheimer's-type retrospective autopsy studies. distinguished from frontotemporal lobar degeneration pathology based on its epidemiology...
Abstract To identify novel causes of familial neurodegenerative diseases, we extended our previous studies TAR DNA‐binding protein 43 (TDP‐43) proteinopathies to investigate TDP‐43 as a candidate gene in cases motor neuron disease. Sequencing the led identification missense mutation, Ala‐315‐Thr, which segregates with all affected members an autosomal dominant disease family. The mutation was not found 1,505 healthy control subjects. discovery family dominantly inherited provides evidence...
Null mutations in the progranulin gene ( PGRN ) were recently reported to cause tau-negative frontotemporal dementia linked chromosome 17. We assessed genetic contribution of an extended population patients with lobar degeneration (FTLD) N =378). Mutations identified 10% total FTLD and 23% a positive family history. This mutation frequency dropped 5% when analysis was restricted unbiased subpopulation =167) derived from referred Alzheimer's Disease Research Centers (ADRC). Among ADRC...
Abstract Demented patients with Parkinson disease share certain neuropathological and neurochemical features suffering from Alzheimer disease. Recently, loss of cholinergic neurons in the basal forebrain, particularly nucleus basalis Meynert, has been implicated pathophysiology The present investigation 12 demonstrates that demented this also show a selective cells thus providing an important link between dementias
Abstract Computer visualization techniques were used to map and quantitatively reconstruct the entire locus coeruleus, including nucleus subcoeruleus, compare topographic patterns of cell loss in postmortem brains from patients with Parkinson's disease, Alzheimer's Down syndrome. There was comparable all three diseases (approximately 60%) compared aged normal subjects, there a significant subcoeruleus cells specifically disease (63%). positive correlation between magnitude coeruleus duration...
Abstract Background A rare variant in the Triggering Receptor Expressed on Myeloid cells 2 ( TREM2 ) gene has been reported to be a genetic risk factor for Alzheimer’s disease by two independent groups (Odds ratio between 2.9-4.5). Given key role of effective phagocytosis apoptotic neuronal microglia, we hypothesized that dysfunction may play more generalized neurodegeneration. With this mind set out assess association disease-related (rs75932628, p.R47H) with other related neurodegenerative...
Rare mutations in the gene encoding for tau (MAPT, microtubule-associated protein tau) cause frontotemporal dementia-spectrum (FTD-s) disorders, including FTD, progressive supranuclear palsy (PSP) and corticobasal syndrome, a common extended haplotype spanning across MAPT locus is associated with increased risk of PSP Parkinson's disease.We identified rare variant (p.A152T) patient clinical diagnosis assessed its frequency multiple independent series patients neurodegenerative conditions...
Abstract Corticobasal degeneration (CBD) is a neurodegenerative disorder affecting movement and cognition, definitively diagnosed only at autopsy. Here, we conduct genome-wide association study (GWAS) in CBD cases ( n =152) 3,311 controls, 67 439 controls replication stage. Associations with meta-analysis were 17q21 MAPT P =1.42 × 10 −12 ), 8p12 lnc-KIF13B-1 , long non-coding RNA (rs643472; =3.41 −8 2p22 SOS1 (rs963731; =1.76 −7 ). Testing for of top progressive supranuclear palsy (PSP) GWAS...
Abstract An international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The suggested staging and nomenclature have proven useful autopsy practice dementia research. However, some issues remain unresolved, such as cases with unusual features that do not fit current diagnostic categories. goal of this is to update the criteria diagnosis LATE-NC, based primarily on published data. We...
Neuropathologic criteria for progressive supranuclear palsy (PSP) proposed by a National Institute of Neurological Disorders and Stroke (NINDS) working group were published in 1994 based on the presence neurofibrillary tangles basal ganglia brainstem. These did not stipulate detection methods or incorporate glial tau pathology. In this study, 14 expert neuropathologists scored digital slides from 10 brain regions stained with hematoxylin eosin (H&E) phosphorylated (AT8) immunohistochemistry....
Abstract Background Neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is released from one cell, gains entry to adjacent or connected and serves as a specific template for its own replication in the cytoplasm. Seeding into complex cytoplasmic milieu happens within hours, implying existence of unknown factors that regulate this process. Methods We used proximity labeling identify proteins control seed amplification 5 h exposure....
Tight junctions (TJs) play a crucial role in the establishment of cell polarity and regulation paracellular permeability epithelia. Here, we show that upon calcium-induced junction biogenesis Madin-Darby canine kidney cells, ABαC, major protein phosphatase (PP)2A holoenzyme, is recruited to apical membrane where it interacts with TJ complex. Enhanced PP2A activity induces dephosphorylation proteins, ZO-1, occludin, claudin-1, associated increased permeability. Expression catalytic subunit...
Clonal deletion provides an important mechanism for the elimination of autoreactive T cells. Deletion is accomplished by programmed cell death directed interaction T-cell receptor (TCR) developing thymocyte with major histocompatibility complex elements in thymic environment. In this report we present evidence to support hypothesis that activation and maturation state may be coupling TCR "death program." We show program open during but closed naive mature However, primary antigenic...
Through an international consortium, we have collected 37 tau- and TAR DNA-binding protein 43 (TDP-43)-negative frontotemporal lobar degeneration (FTLD) cases, present here the first comprehensive analysis of these cases in terms neuropathology, genetics, demographics clinical data. 92% (34/37) had fused sarcoma (FUS) pathology, indicating that FTLD-FUS is important FTLD subtype. This collection specifically focussed on aFTLD-U one three recently defined subtypes FTLD-FUS. The subtype...