A5001230537- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Frailty in Older Adults
- Nutritional Studies and Diet
- Neurological Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Hormonal and reproductive studies
- Diet and metabolism studies
- Acute Ischemic Stroke Management
- Cardiovascular Syncope and Autonomic Disorders
- Pharmaceutical Practices and Patient Outcomes
- Menopause: Health Impacts and Treatments
- Alzheimer's disease research and treatments
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Gut microbiota and health
- Mobile Health and mHealth Applications
- Chronic Disease Management Strategies
- Advanced Neuroimaging Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Birth, Development, and Health
- Advanced MRI Techniques and Applications
Amsterdam UMC Location Vrije Universiteit Amsterdam
2016-2025
Public Health Service of Amsterdam
2024-2025
Amsterdam University Medical Centers
2018-2025
Vrije Universiteit Amsterdam
2010-2025
Amsterdam Neuroscience
2014-2024
Geneeskundige en Gezondheidsdienst
2023
University of Amsterdam
2023
General Department of Preventive Medicine
2007-2020
Otto Wagner Hospital
2019
University Medical Center
2011-2017
Abstract Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging–Alzheimer's Association describes biomarker‐based pathologic definition of focused amyloid, tau, neuronal injury. In response this article, here we first discussed that dysfunction is an important early event in...
Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating substances in patients with early forms of Alzheimer disease (AD), and if so, to examine extent pattern leakage. Materials Methods This study was approved by local medical ethical committees Maastricht University Medical Center Leiden Center, written informed consent obtained from all subjects. For this pilot study, 16 AD 17 healthy age-matched control subjects underwent dynamic contrast material-enhanced...
Background: Sex hormone levels in men change during aging. These changes may be associated with insulin sensitivity and the metabolic syndrome.
Abstract Aims The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-OP) risk model estimate 5- 10-year cardiovascular disease (CVD) in individuals aged over 70 years four geographical regions. Methods results Sex-specific competing risk-adjusted models for estimating CVD (CVD mortality, myocardial infarction, or stroke) were derived 65 without pre-existing atherosclerotic from Cohort Norway (28 503 individuals, 10 089 events). Models included age, smoking status,...
Preliminary evidence from animal and human studies shows that gut microbiota composition levels of microbiota-derived metabolites, including short-chain fatty acids (SCFAs), are associated with blood pressure (BP). We hypothesized faecal derived metabolites may be differently BP across ethnic groups.We included 4672 subjects (mean age 49.8 ± 11.7 years, 52% women) six different groups participating in the HEalthy Life In an Urban Setting (HELIUS) study. The was profiled using 16S rRNA gene...
Several studies have reported alterations in gut microbiota composition of Alzheimer's disease (AD) patients. However, the observed differences are not consistent across studies. We aimed to investigate associations between and AD biomarkers using machine learning models patients with dementia, mild cognitive impairment (MCI) subjective decline (SCD).
To determine the relationship between aging, life-style factors and health-related endogenous sex hormone levels.Cross-sectional study of 400 independently living men 40 80 Years age.After exclusion subjects who were not physically or mentally able to visit center, randomly selected from a population-based sample. Total testosterone (TT), bioavailable (BT) (i.e. bound hormone-binding globulin (SHBG)), SHBG, estradiol (E(2)) dehydroepiandrosterone-sulfate (DHEA-S) investigated for their with...
The burden of atherosclerosis especially afflicts the increasing older segment population. Recent evidence has emphasized a protective role endogenous sex hormones in development aging men.We studied association between and progression 195 independently living elderly men. Participants underwent measurements carotid intima-media thickness (IMT) at baseline 1996 again 2000. At baseline, serum concentrations testosterone (total free) estradiol free E2) were measured. Serum inversely related to...
Livers from hypophysectomized (hypox)rats were perfused with oxygenated Waymouth's medium in a system which permitted continuous recirculation for separate 30minute periods after fresh was supplied. In most experiments 6changes of carried out over 3 hour period. The somatomedin activity each perfusate determined by measuring its ability to stimulate sulfate uptake hypox rat cartilage vitro. For comparison between the results are expressed as per cent stimulation sulfateuptake compared...
Cerebral hypoperfusion is among the mechanisms that may explain association of high blood pressure (BP) with dementia. However, few data are available on longitudinal hypertension and cerebral perfusion.We examined hypertension, BP, antihypertensive drugs change in parenchymal flow (pCBF) 575 patients manifest atherosclerotic disease (mean age, 57 ± 10 years) from SMART-MR study. Total CBF was measured at baseline follow-up magnetic resonance (MR) angiography expressed per 100ml brain volume...
<i>Background/Aims:</i> The metabolic syndrome (MeSy) may be related to Alzheimer’s disease (AD). Our aims were investigate the association of MeSy with incident dementia in a multiethnic elderly cohort United States. <i>Methods:</i> We conducted cross-sectional and prospective analyses 2,476 men women aged 65 years older data available on diagnosis Northern New York City. was defined by National Cholesterol Education Program Adult Treatment III European Group for...
Cardiovascular disease (CVD) has been associated with an increased risk of frailty, but the direction association remains unclear. This study set out to examine bidirectional longitudinal between CVD and frailty over extended period time. Data are from 1432 older adults (aged 65-88yrs) Longitudinal Aging Study Amsterdam (LASA), who were followed for 17 years. At baseline follow-up, was assessed through self-report, medication use medical records, classified as angina pectoris, myocardial...
<h3>Importance</h3> Decision-making on management of proximal femoral fractures in frail patients with limited life expectancy is challenging, but surgical overtreatment needs to be prevented. Current literature provides insight into the true outcomes nonoperative and operative this patient population. <h3>Objective</h3> To investigate vs institutionalized older expectancy. <h3>Design, Setting, Participants</h3> This multicenter cohort study was conducted between September 1, 2018, April 25,...
<h3>Abstract</h3> The improvement of next-generation sequencing technologies has promoted the field immunogenetics and produced numerous immunogenomics data. Modern data-driven research power to promote novel biomedical discoveries through secondary analysis such Therefore, it is important ensure with great reproducibility robustness for promoting a precise accurate In scientific research, rigorous conduct in designing conducting experiments needed, specifically articulate writing, reporting...
Estimation of serum concentrations free testosterone (FT) and bioavailable (bioT) by calculation is an inexpensive uncomplicated method. We compared results obtained with 5 different algorithms.We used published algorithms [described Sodergard et al. (bioTS FTS), Vermeulen (bioTV FTV), Emadi-Konjin (bioTE), Morris (bioTM), Ly (FTL)] to estimate bioT FT in samples from 399 independently living men (ages 40-80 years) participating a cross-sectional, single-center study.Mean was highest for...
Falls occur frequently in older people and strongly affect quality of life. Guidelines recommend multifactorial, targeted fall prevention. We evaluated the effectiveness a multifactorial intervention persons with high risk recurrent falls.A randomized controlled trial was conducted from April 3, 2005, to July 21, 2008, at geriatric outpatient clinic university hospital regional general practices Netherlands. Of 2015 identified, 217 aged 65 years or were selected participate. They had falls...
<h3>Objective:</h3> We hypothesized that in participants with a history of hypertension, lower late-life blood pressure (BP) will be associated more brain pathology. <h3>Methods:</h3> Participants are 4,057 older men and women without dementia midlife (mean age 50 ± 6 years) 76 5 vascular screening, cognitive function, structures on MRI ascertained as part the Age, Gene/Environment Susceptibility (AGES)–Reykjavik Study. <h3>Results:</h3> The association BP to measures depended hypertension...