A5000676012- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Frailty in Older Adults
- Health and Medical Studies
- Medical Malpractice and Liability Issues
- Nutrition and Health in Aging
- Chronic Disease Management Strategies
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Medical and Health Sciences Research
- Dementia and Cognitive Impairment Research
- Obstructive Sleep Apnea Research
- Patient Safety and Medication Errors
- Travel-related health issues
- Vaccine Coverage and Hesitancy
- Emergency and Acute Care Studies
- Medical Practices and Rehabilitation
- Rheumatoid Arthritis Research and Therapies
- Antibiotic Use and Resistance
- Lipoproteins and Cardiovascular Health
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
Utrecht University
2022-2024
University Medical Center Utrecht
2022-2024
Vrije Universiteit Amsterdam
2017-2023
Amsterdam University Medical Centers
2019-2023
Henry Ford Hospital
2017-2023
Geneeskundige en Gezondheidsdienst
2023
Amsterdam Neuroscience
2019-2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2009-2021
British Medical Association
2009-2017
Charité - Universitätsmedizin Berlin
2012-2016
Objectives The primary aim was to investigate the impact of complaints on doctors’ psychological welfare and health. secondary assess whether doctors report exposure a process is associated with defensive medical practise. Design This cross-sectional anonymous survey study. Participants were stratified into recent/current, past, no complaints. Each group completed tailored versions survey. 95 636 invited participate. A total 10 930(11.4%) responded, 7926 (8.3%) full included in complete...
Cardiovascular disease (CVD) has been associated with an increased risk of frailty, but the direction association remains unclear. This study set out to examine bidirectional longitudinal between CVD and frailty over extended period time. Data are from 1432 older adults (aged 65-88yrs) Longitudinal Aging Study Amsterdam (LASA), who were followed for 17 years. At baseline follow-up, was assessed through self-report, medication use medical records, classified as angina pectoris, myocardial...
Delay of routine medical care during the COVID-19 pandemic may have serious consequences for health and functioning older adults. The aim this study was to investigate whether adults reported cancellation or avoidance first months pandemic, explore associations with socio-demographic characteristics.Cross-sectional data 880 aged ≥ 62 years (mean age 73.4 years, 50.3% female) were used from questionnaire Longitudinal Aging Study Amsterdam, a cohort among community-dwelling in Netherlands....
Abstract Background Fahr’s disease and syndrome are rare disorders leading to calcification of the small arteries in basal ganglia brain, resulting a wide range symptoms comprising cognitive decline, movement neuropsychiatric symptoms. No disease-modifying therapies available. Studies have shown potential treatment ectopic vascular calcifications with bisphosphonates. This paper describes rationale design CALCIFADE trial which evaluates effects etidronate patients or syndrome. Methods The is...
Objectives To examine doctors' experiences of complaints, including which aspects are most stressful. We also investigated how doctors felt complaints processes could be improved. Design and methods A qualitative study based on a cross-sectional survey members the British Medical Association (BMA). asked following: (1) Try to summarise as best you can your experience process it made feel. (2) What were stressful complaint? (3) would improve in system? Participants sent 95 636 doctors,...
Objective. Cardiovascular (CV) disease (CVD) risk is increased in rheumatoid arthritis (RA). However, longterm followup studies investigating this are scarce. Methods. The CARRÉ (CARdiovascular research and RhEumatoid arthritis) study a prospective cohort CVD its factors 353 patients with longstanding RA. CV endpoints were assessed at baseline 3, 10, 15 years after the start of compared to reference (n = 2540), including large number type 2 diabetes (DM). Results. Ninety-five RA developed...
Abstract Purpose Older adults at the emergency department (ED) with polypharmacy, comorbidity, and frailty are risk of adverse health outcomes. We investigated association polypharmacy outcomes, in relation to comorbidity frailty. Methods This is a prospective cohort study ED patients ≥ 70 years. Non-polypharmacy was defined as 0–4 medications, 5–9 excessive 10. Comorbidity classified by Charlson index (CCI). Frailty Identification Seniors At Risk—Hospitalized Patients (ISAR-HP) score. The...
Abstract Background Diabetes overtreatment is a frequent and severe issue in multimorbid older patients with type 2 diabetes (T2D). Objective This study aimed at assessing the association between 1-year functional decline, hospitalisation mortality inpatients multimorbidity polypharmacy. Methods Ancillary of European multicentre OPERAM project on aged ≥70 years T2D glucose-lowering treatment (GLT). was defined according to 2019 Endocrine Society guideline using HbA1c target range...
How adverse outcomes and complaints are managed may significantly impact on physician well-being practice. We aimed to investigate how depression, anxiety defensive medical practice associated with doctors actual perceived support, behaviour of colleagues process issues regarding investigations carried out.A survey study. Respondents were classified into three groups: no complaint, recent/current complaint (within 6 months) or past complaint. Each group completed specific surveys.British...
Background: Orthostatic hypotension (OH) has been cross-sectionally and longitudinally related to dementia in the general population. Whether OH contributes clinical progression mild cognitive impairment (MCI) or is less certain. Also, differences risk of between patients with early (EOH) versus delayed and/or prolonged (DPOH) are unclear. Objective: Assess prevalence EOH DPOH, investigate longitudinal association DPOH either incident MCI dementia. Methods: 1,882 from Amsterdam Dementia...
Frailty is associated with a higher risk of mortality, but not much known about underlying pathways the frailty-mortality association. In this study, we explore wide range possible mediators relation between frailty and mortality. Data were used from Longitudinal Aging Study Amsterdam (LASA). We included 1477 older adults aged 65 years over who participated in study 2008-2009 linked their data to register on mortality up 2015. examined lifestyle, social, psychological, cognitive, physical...
Older adults at the Emergency Department (ED) often present with nonspecific complaints (NSC) such as 'weakness' or 'feeling unwell'. Health care workers may underestimate illness in patients NSC, leading to adverse health outcomes. This study compares characteristics and outcomes of NSC-patients versus specific (SC) patients.Cohort ≥ 70 years two Dutch EDs. NSC was classified according BANC-study-framework based on medical history ED letter, before additional diagnostics took place. A...
Purpose Published studies have shown that pharmacists on medical rounds reduce the incidence of preventable adverse drug events (ADEs). However, impact a dedicated pharmacist who provides consistent patient care in critical unit remains to be evaluated. Objective To determine is permanently assigned intensive (MICU) ADEs, charges, and length stay (LOS) MICU. Design A randomized, experimental versus historical control group design was used. Preventable ADEs were identified validated by 2...
<b><i>Introduction:</i></b> In older patients, life expectancy is determined by a complex interaction of multiple geriatric domains. A comprehensive assessment (CGA) captures different Yet, if and how components the CGA are related to mortality in an outpatient setting unknown. Amsterdam Ageing Cohort, we therefore studied distribution accumulation domain deficits relation mortality. <b><i>Methods:</i></b> All patients received as part standard...
Introduction: Orthostatic hypotension is a common condition associated with an increased mortality risk. This study investigates this association specifically in geriatric outpatients and additionally focuses on the duration magnitude of orthostatic hypotension. Methods: In observational prospective cohort from Amsterdam Ageing cohort, we differentiated early (EOH) delayed/prolonged (DPOH). The drop both SBP DBP after either 1 or 3 min was quantified. Mortality data obtained Dutch municipal...
Reanimationsmaßnahmen (externe Herzdruckmassage, [Früh-]Defibrillation, Atemwegssicherung, Medikamenten- und Volumenapplikation) können potenziell lebensrettend sein, beinhalten allerdings z. T. nicht unerhebliche Verletzungsrisiken für den Patienten, welche allein oder in Kombination nur initialen Erfolg der Reanimationsbemühungen limitieren, sondern auch nach inital erfolgreicher Wiederbelebung im klinischen Verlauf zu schwerwiegenden Komplikationen führen können. Wir berichten Synopsis...
Abstract Aims Physical frailty screening is more commonly performed at outpatient heart failure (HF) clinics. However, this does not incorporate other common geriatric domains. This study assesses whether a multidomain assessment, in comparison with HF severity or physical frailty, associated short‐term adverse outcomes. Methods and results prospective cohort of 197 patients (mean age 78, 44% female) attending was assessed New York Heart Association class (I‐II versus III‐IV) N‐terminal pro...
Older adults presenting to the emergency department (ED) are at high risk of adverse health outcomes. This study aimed evaluate accuracy 4 frequently used screening instruments for prediction outcomes among older in ED.This was a prospective cohort patients ≥70 years age ED 2 hospitals Netherlands. Screening included acutely patient program (APOP) (providing scores-functional decline [APOP1] and mortality [APOP2]), International Resident Assessment Instrument Emergendy Department screener...
This study aimed to investigate the interrelation between slowing in walking, thinking and mood, their relationship with cerebral small vessel disease (CSVD) a geriatric population.Cross-sectional study.566 outpatients from Amsterdam Aging Cohort (49% female; age 79 ±6 years), who visited UMC outpatient memory clinic.Patients underwent comprehensive assessment, brain imaging, neuropsychological assessment as part of medical care. Three aspects were investigated: gait speed, processing apathy...