A5006978988- Nitric Oxide and Endothelin Effects
- Atrial Fibrillation Management and Outcomes
- Eicosanoids and Hypertension Pharmacology
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Disease and Adiposity
- Chronic Disease Management Strategies
- Cardiac Arrhythmias and Treatments
- Venous Thromboembolism Diagnosis and Management
- Electron Spin Resonance Studies
- Peripheral Artery Disease Management
- Coronary Interventions and Diagnostics
- Influenza Virus Research Studies
- Fatty Acid Research and Health
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Thyroid Disorders and Treatments
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Renin-Angiotensin System Studies
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
University of Bern
2020-2024
University Hospital of Bern
2019-2024
University Hospital of Basel
2021
University of Basel
2021
Primary HealthCare
2021
Primary Health Care
2021
University Hospital of Zurich
2021
Population Health Research Institute
2021
McMaster University
2021
Ospedale San Giovanni Bellinzona
2021
Abstract Objective To examine the effect of optimising drug treatment on related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design Cluster randomised controlled trial. Setting 110 clusters inpatient wards within university based hospitals four European countries (Switzerland, Netherlands, Belgium, Republic Ireland) defined by attending doctors. Participants 2008 (≥70 years) (≥3 chronic conditions) (≥5 drugs used long term). Intervention...
Endogenous estrogens protect from coronary artery disease in premenopausal women, but the mechanisms involved are only partly understood. This study investigated whether activation of novel G protein-coupled estrogen receptor (GPER, formerly known as GPR30) affects tone, and this is affected by concomitant blockade receptors (ER) alpha beta. Rings epicardial porcine arteries suspended organ chambers were precontracted with prostaglandin F(2)alpha, direct effects G-1 (GPER agonist) ICI...
Abstract Background Diabetes overtreatment is a frequent and severe issue in multimorbid older patients with type 2 diabetes (T2D). Objective This study aimed at assessing the association between 1-year functional decline, hospitalisation mortality inpatients multimorbidity polypharmacy. Methods Ancillary of European multicentre OPERAM project on aged ≥70 years T2D glucose-lowering treatment (GLT). was defined according to 2019 Endocrine Society guideline using HbA1c target range...
Background Diabetes is a major risk factor for atrial fibrillation (AF). However, it remains unclear whether individual AF phenotype and related comorbidities differ between patients who have with without diabetes. This study investigated the association of diabetes cardiac neurological in documented AF. Methods Results Participants multicenter Swiss‐AF (Swiss Atrial Fibrillation) data on were eligible. Primary outcomes parameters phenotype, including type, symptoms, quality life (assessed...
Abstract Background In multimorbid older patients with type 2 diabetes mellitus (T2DM), the intensity of glucose‐lowering medication (GLM) should be focused on attaining a suitable level glycated hemoglobin (HbA 1c ) while avoiding side effects. We aimed at identifying overtreatment T2DM as well associated risk factors. Methods secondary analysis multicenter study patients, we evaluated HbA levels among T2DM. Patients were aged ≥70 years, multimorbidity (≥3 chronic diagnoses) and...
Levels of the endothelium-derived peptide endothelin-1 (ET-1) are elevated in obese humans, and ET-1 mediated vascular tone is increased. Renal arterial smooth muscle highly responsive to ET-1. Whether or not affects contractions renal artery under normal conditions obesity unknown. The present study was designed investigate whether overexpression endogenous endothelium responsiveness main segmental arteries differently obesity.Mice with tie-1 promoter-driven endothelium-restricted...
The omega-3 fatty acid (n-3 FA) eicosapentaenoic (EPA) reduces stroke in patients with atherosclerotic cardiovascular disease. Whether EPA affects or cerebral small vessel dis-ease atrial fibrillation (AF) remains uncertain. EPA, docosahexaenoic (DHA), docosapentaenoic (DPA), and alpha-linolenic (ALA) were determined by gas chromatography 1657 AF from the Swiss Atrial Fibrillation study. All underwent brain MRI to detect ischemic infarcts, classified as large noncortical cortical infarcts...
<h3>BACKGROUND:</h3> Little is known about the association between alcohol consumption and risk of cardiovascular events in patients with established atrial fibrillation (AF). The main aim current study was to investigate associations regular intake incident stroke or systemic embolism AF. <h3>METHODS:</h3> To assess AF, we combined data from 2 comparable prospective cohort studies that followed 3852 AF for a median 3.0 years. Patients were grouped into 4 categories daily (none, > 0 <...
Abstract Context Subclinical thyroid dysfunction and anemia are common disorders, both have increasing prevalence with advancing age. Objective The aim of this study was to assess whether levothyroxine treatment leads a rise in hemoglobin levels older persons subclinical hypothyroidism. Methods This preplanned combined analysis 2 randomized controlled trials included community-dwelling aged 65 years hypothyroidism who were randomly assigned or placebo treatment. dose periodically titrated...
Abstract Background Patients with atrial fibrillation (AF) have a high risk of hospital admissions, but there is no validated prediction tool to identify those at highest risk. Purpose To develop and externally validate score for all-cause admissions in patients AF. Methods We used prospective cohort 2387 established AF as derivation cohort. Independent factors were selected from broad range variables using the least absolute shrinkage selection operator (LASSO) method fit Cox regression...
Abstract Context Subclinical thyroid dysfunction (ScTD) comprising subclinical hypothyroidism (SHypo) and hyperthyroidism (SHyper) has been associated with increased risk for cardiovascular events. Objective To assess associations between ScTD factors (cvRFs) according to age sex. Design Setting Pooled individual participant data analysis of large prospective cohort studies from the Thyroid Studies Collaboration. Participants Aged 18 103 years SHypo (TSH &gt;4.50 mU/l, normal fT4) SHyper...
To develop and externally validate a risk score for all-cause hospital admissions in patients with atrial fibrillation.We used prospective cohort of 2387 established fibrillation as derivation cohort. Independent factors were selected from broad range variables using the least absolute shrinkage selection operator method fit to Cox model. The was validated separate 1300 patients. incidence admission 19.1 per 100 person-years it 26.1 validation most important predictors age (75-79 years:...
The beneficial effect of statins on the risk recurrence cardiovascular disease (secondary prevention) is well demonstrated. In primary prevention (no symptomatic disease), benefit after age 70 years less clear and elderly patients with comorbidities have often been excluded from large, randomized trials. Some ongoing clinical trials will provide more information potential benefits risks starting or stopping in older adults. practice, decision to treat needs take into account age,...
<b><i>Background:</i></b> Aging, obesity, and diabetes favor vascular dysfunction. Endothelial activation of adenosine monophosphate-activated protein kinase (AMPK) has protective effects in diabetes. <b><i>Methods:</i></b> Mice with constitutive endothelial AMPK (CA-AMPK) were given a high fat diet to induce obesity or kept on standard chow as lean controls for up 2 years. A subset obese animals was changed after 30 weeks feeding....
Background Older adults with chronic conditions are at high risk of complications from influenza and pneumococcal infections. Evidence about factors associated vaccination among older multimorbid persons in Europe is limited. The aim this study was to investigate the prevalence determinants these vaccinations population. Methods Multimorbid patients aged ≥70 years polypharmacy were enrolled 4 European centers Switzerland, Belgium, Netherlands, Ireland. Data on vaccinations, demographics,...
Endothelium-dependent contractions are augmented in human hypertension and isolated preparations, including renal arteries, from hypertensive animals. Renal vasomotor tone is essential the regulation of arterial blood pressure arteries highly sensitive to vasoconstrictor prostanoids prostacyclin, identified as endothelium-derived contracting factor (EDCF) activating thromboxane prostanoid (TP) receptors. However, mechanisms underlying increased EDCF responses not completely resolved....
Poster Session 1: Oncology, Renal Physiology and Disease, Neurology, Infectious Diseases, New Topics of Endothelin Biology: P-26