A5025423190- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Medication Adherence and Compliance
- Chronic Disease Management Strategies
- Schizophrenia research and treatment
- Patient Safety and Medication Errors
- Blood Pressure and Hypertension Studies
- Pharmaceutical studies and practices
- Herpesvirus Infections and Treatments
- Pharmacovigilance and Adverse Drug Reactions
- Nursing Roles and Practices
- Cytomegalovirus and herpesvirus research
- Psychiatric care and mental health services
- Antibiotics Pharmacokinetics and Efficacy
- Chemotherapy-related skin toxicity
- Peripheral Neuropathies and Disorders
- HER2/EGFR in Cancer Research
- Sepsis Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Bacterial Identification and Susceptibility Testing
University Medical Center Utrecht
2018-2024
Utrecht University
2020-2022
Heidelberg University
2021-2022
University Hospital Heidelberg
2021-2022
St. Antonius Ziekenhuis
2020-2021
Abstract Objective To examine the effect of optimising drug treatment on related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design Cluster randomised controlled trial. Setting 110 clusters inpatient wards within university based hospitals four European countries (Switzerland, Netherlands, Belgium, Republic Ireland) defined by attending doctors. Participants 2008 (≥70 years) (≥3 chronic conditions) (≥5 drugs used long term). Intervention...
Abstract Background Several approaches to medication optimisation by identifying drug-related problems in older people have been described. Although some interventions shown reductions (DRPs), evidence supporting the effectiveness of reviews on clinical and economic outcomes is lacking. Application STOPP/START (version 2) explicit screening tool for inappropriate prescribing has decreased significantly reduced adverse drug reactions (ADRs) associated healthcare costs patients with...
The Screening Tool of Older Persons' Prescriptions (STOPP)/Screening to Alert Right Treatment (START) instrument is used evaluate the appropriateness medication in older people. STOPP/START criteria have been converted into software algorithms and implemented a clinical decision support system (CDSS) facilitate their use practice.
Abstract Background Electronic clinical decision support systems (eCDSS), such as the ‘Systematic Tool to Reduce Inappropriate Prescribing’ Assistant (STRIPA), have become promising tools for assisting general practitioners (GPs) with conducting medication reviews in older adults. Little is known about how GPs perceive eCDSS-assisted recommendations pharmacotherapy optimization. The aim of this study was explore implementation a review intervention centered around STRIPA ‘Optimising...
Introduction Multimorbidity and polypharmacy are major risk factors for potentially inappropriate prescribing (eg, overprescribing underprescribing), systematic medication reviews complex time consuming. In this trial, the investigators aim to determine if a software-based review improves appropriateness more than standard care in older, multimorbid patients with polypharmacy. Methods analysis Optimising PharmacoTherapy elderly primary CAre is cluster randomised controlled trial that will...
Objectives Appropriate prescribing in older people continues to be challenging. Studies still report a high prevalence of inappropriate people. To reduce the problem underprescribing and overprescribing this population, explicit drug optimisation tools like Screening Tool Older Persons’ potentially Prescriptions/Screening Alert Right Treatment (STOPP/START) have been developed. The aim study was evaluate clinical applicability STOPP/START criteria daily patient care by assessing clarity...
Abstract Objective To evaluate the agreement of hospital physicians and older patients with individualised STOPP/START-based medication optimisation recommendations from a pharmacotherapy team. Methods This study was embedded within large European, multicentre, cluster randomised controlled trial examining effect structured review on drug-related admissions in multimorbid (≥ 3 chronic conditions) people 70 years) polypharmacy 5 medications), called OPERAM. Data Dutch intervention arm this...
Multimorbidity and polypharmacy are risk factors for drug-related hospital admissions (DRAs) in the ageing population. DRAs caused by medication errors (MEs) considered potentially preventable. The STOPP/START criteria were developed to detect potential MEs older people.
What is known and objective Trastuzumab-emtansine an antibody-drug conjugate developed to decrease off-target toxicity. According the product label, reactions secondary extravasation are mild or moderate. Case summary We report on a 51-year-old woman who epidermal necrosis after of trastuzumab-emtansine, which required surgical intervention. Six weeks later, lesions were healed with residual hyperpigmentation. new conclusion describe course case severe toxicity following...
Acyclovir is a hydrophilic drug that mainly distributed in the lean compartments of body. Consequently, dosing on total body weight obese patients may lead to overdosing. Inconsistency clinical guideline recommendations and lack clear Summary Product Characteristics how dose acyclovir can impede safe effective treatment. This report describes 71-year-old patient (body mass index 35 kg/m2) with herpes zoster ophthalmicus meningoencephalitis. The had normal renal function was treated dosage...
Abstract Purpose Adverse drug reactions (ADRs) account for 10% of acute hospital admissions in older people, often under-recognised by physicians. The Dutch geriatric guideline recommends screening all acutely admitted patients with polypharmacy an ADR trigger tool comprising ten triggers and associated drugs frequently causing ADRs. This study investigated the performance this recognition usual care ADRs detected tool. Methods A cross-sectional was performed ≥ 70 years to ward University...
OBJECTIVE: To evaluate agreement of hospital physicians and older patients with individualised STOPP/START based medication optimisation recommendations from a pharmacotherapy team. METHODS: This study was embedded within large European, multicentre, cluster randomised controlled trial examining the effect structured review on drug-related admissions in multimorbid (≥3 chronic conditions) people (≥70 years) polypharmacy (≥5 medications). Data Dutch intervention arm this were used for study....
Abstract Background. Limited data are available on characteristics associated with antipsychotic’s use in multimorbid older adults. Aims. (1) To identify factors antipsychotic prescribing inpatients, (2) to assess the association between and drug-related readmission (DRA) within one year. Method. This is a secondary analysis of OPERAM randomized controlled trial which evaluated impact structured medication review DRA polymedicated inpatients aged ³70. Multivariate assessed comorbidities...