Mark G. Filipovic
A5007222648- Cardiac, Anesthesia and Surgical Outcomes
- Atrial Fibrillation Management and Outcomes
- Fatty Acid Research and Health
- Enhanced Recovery After Surgery
- Hemodynamic Monitoring and Therapy
- Cardiac Imaging and Diagnostics
- Patient Satisfaction in Healthcare
- Patient Safety and Medication Errors
- Heart Failure Treatment and Management
- Anesthesia and Pain Management
- Cardiovascular Function and Risk Factors
- Airway Management and Intubation Techniques
- Blood transfusion and management
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
- Healthcare Technology and Patient Monitoring
- Healthcare Quality and Management
- Acute Ischemic Stroke Management
- Musculoskeletal pain and rehabilitation
- Digital Imaging in Medicine
- Cardiac Valve Diseases and Treatments
- Healthcare Operations and Scheduling Optimization
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Fibrosis and Remodeling
- Biomarkers in Disease Mechanisms
University Hospital of Bern
2022-2025
University of Bern
2022-2025
Kantonsspital Baden
2016-2022
Kantonsspital Winterthur
2021
University of Zurich
2018
Point-of-care gastric sonography offers an objective approach to assessing individual pulmonary aspiration risk before induction of general anaesthesia. We aimed evaluate the potential impact routine pre-operative ultrasound on peri-operative management in a cohort adult patients undergoing elective or emergency surgery at single centre. According results, were classified as low (empty, fluid volume ≤ 1.5 ml.kg-1 body weight) high (solid, mixed > aspiration. After sonography, examiners asked...
Accurate prediction of intensive care unit (ICU) admission and length stay (LOS) after major surgery is essential for optimizing patient outcomes healthcare resources. Factors such as age, BMI, comorbidities, perioperative complications significantly influence ICU admissions LOS. Machine learning methods have been increasingly utilized to predict these outcomes, but their clinical utility beyond traditional metrics remains underexplored. This study examined a sub-cohort 6043 patients who...
BACKGROUND Clinical practice in patients at risk of pulmonary aspiration varies widely. However, data on actual management, decision-driving factors and controversial issues remain elusive. OBJECTIVE We aimed to comprehensively review the management identify controversies among anaesthesia professionals. DESIGN National interprofessional survey. SETTING All departments Switzerland. PARTICIPANTS The survey was distributed electronically all members Swiss Society Anaesthesiology Perioperative...
Background: Omega-3 fatty acids (n − 3 FA) may have blood pressure (BP)-lowering effects in untreated hypertensive and elderly patients. The effect of n FA on BP young, healthy adults remains unknown. Index reliably reflects an individuals' omega-3 status. We hypothesized that the is inversely associated with levels young adults. Methods: current study = 2036) a cross-sectional investigating baseline characteristics cohort, which includes adults, age 25–41 years. Individuals cardiovascular...
BACKGROUND: Clinical prediction modeling plays a pivotal part in modern clinical care, particularly predicting the risk of in-hospital mortality. Recent efforts have focused on leveraging intraoperative data sources to improve model performance. However, individual and collective benefit pre- for decision-making remains unknown. We hypothesized that predictors contribute equally net decision curve analysis (DCA) mortality models include predictors. METHODS: Data from VitalDB database...
Indoleamine 2,3-deoxygenase (IDO) plays an important role in the catabolism of amino acid tryptophan. Tryptophan and its metabolites are key immune modulators. Increased IDO activity has been observed various diseases is associated with worse clinical outcomes. However, comprehensive research regarding cardiac surgery remains limited. Therefore, we aimed to investigate perioperative changes pathway metabolites, along their impact on outcomes adult patients undergoing surgery. As...
Sustained forms of atrial fibrillation (AF) may be associated with a higher risk adverse outcomes, but few if any long-term studies took into account changes AF type and co-morbidities over time. We prospectively followed 3843 patients collected information on during yearly follow-ups. The primary outcome was composite stroke or systemic embolism (SE). Secondary outcomes included myocardial infarction, hospitalization for congestive heart failure (CHF), bleeding all-cause mortality....
Ketone bodies (KBs) are energy-efficient substrates utilized by the heart depending on its metabolic demand and substrate availability. Levels of circulating KBs have been shown to be elevated in acute chronic cardiovascular disease associated with severity patients failure functional outcome after myocardial infarction. To investigate whether this pattern similarly applies undergoing cardiac surgery involving cardiopulmonary bypass (CPB), we analysed prospectively collected pre-...
Summary Introduction Point‐of‐care gastric ultrasound is an emerging tool in peri‐operative practice. However, data on the technical challenges of ultrasound, which are essential for optimised training, remain scarce. We analysed examinations performed after basic training to identify factors associated with difficulty. Methods This was analysis from a prospective observational study evaluating potential impact routine pre‐operative management adult patients undergoing elective or emergency...
Preventive strategies against diagnostic errors require the knowledge of underlying mechanisms. We examined effects a wrong priori diagnosis on accuracy focussed assessment in an acute myocardial infarction scenario. One-hundred-and-fifty-six medical students (cohort 1) were randomized to three study arms differing revealed: no (control group), (correct and pulmonary embolism (wrong group). Forty-four physicians 2) control group group. Primary endpoint was participants’ final presumptive...
The association of blood pressure (BP) and hypertension with the presence different types brain lesions in patients atrial fibrillation is unclear. BP values were obtained a multicenter cohort fibrillation. Systolic diastolic was categorized predefined groups. All underwent magnetic resonance imaging neurocognitive testing. Brain classified as large noncortical or cortical infarcts, small microbleeds, white matter lesions. White graded according to Fazekas scale. Overall, 1738 enrolled this...
The omega-3 fatty acid (n-3 FA) eicosapentaenoic (EPA) reduces stroke in patients with atherosclerotic cardiovascular disease. Whether EPA affects or cerebral small vessel dis-ease atrial fibrillation (AF) remains uncertain. EPA, docosahexaenoic (DHA), docosapentaenoic (DPA), and alpha-linolenic (ALA) were determined by gas chromatography 1657 AF from the Swiss Atrial Fibrillation study. All underwent brain MRI to detect ischemic infarcts, classified as large noncortical cortical infarcts...
Background Previous randomized control trials showed mixed results concerning the effect of omega-3 fatty acids (n-3 FAs) on atrial fibrillation (AF). The associations n-3 FA blood levels with heart rhythm in patients established AF are unknown. goal this study was to assess total and individual type (paroxysmal versus nonparoxysmal), rate (HR), HR variability AF. Methods Results Total FAs, eicosapentaenoic acid, docosahexaenoic docosapentaenoic alpha-linolenic acid were determined 1969...
Background Molecular mechanisms underlying perioperative acute phase reactions in cardiac surgery are largely unknown. We aimed to characterise alterations of the plasma proteome a cohort adult patients undergoing on-pump using high-throughput mass spectrometry and identify candidate proteins potentially relevant postoperative clinical outcome through novel, multi-step approach. Methods This study is an analysis Bern Perioperative Biobank, prospective adults who underwent with use...